Exercise Therapy for Adenomatous Polyposis
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores the ideal amount of exercise for managing familial adenomatous polyposis (FAP), a condition that causes multiple polyps in the colon and rectum. Participants will engage in supervised treadmill walking as part of endurance exercise therapy to determine the optimal exercise level for future studies. The trial seeks individuals with FAP who have more than 50 colorectal adenomas and currently exercise less than 60 minutes per week. The aim is to assess whether exercise can aid in managing FAP.
As an unphased study, this trial offers a unique opportunity to contribute to groundbreaking research that could enhance FAP management through exercise.
Do I need to stop my current medications to join the trial?
The trial does not specify if you need to stop taking your current medications. However, you cannot start taking certain medications like NSAIDs or weight loss drugs within 3 months before the trial or during it.
What prior data suggests that this exercise therapy is safe?
Research shows that exercise, such as walking on a treadmill, is generally safe. Although specific safety information for individuals with adenomatous polyposis is lacking, exercise has been studied for its health benefits. Studies indicate that regular exercise can reduce the risk of colorectal cancer and lower the number of polyps, suggesting it is usually well-tolerated. While this trial aims to determine the optimal amount of exercise for future studies, past research supports exercise as a safe option for many people.12345
Why are researchers excited about this trial?
Unlike the standard treatments for adenomatous polyposis, which often involve surgery or medication to manage polyp growth, endurance exercise therapy offers a non-invasive alternative. This approach focuses on treadmill walking to potentially influence the body's natural processes, which could reduce or manage polyps without the need for more aggressive interventions. Researchers are excited because exercise therapy might harness the body's own mechanisms to achieve results, offering a safer and potentially more accessible option for patients.
What evidence suggests that exercise therapy is effective for adenomatous polyposis?
Research has shown that physical fitness, improved through regular exercise, might help prevent colorectal cancer. Studies have found that exercise can reduce the total number of intestinal growths, called polyps, by half and decrease the number of larger polyps by 67%. Clinical trials and reviews of multiple studies consistently demonstrate that exercise effectively lowers the risk of colorectal cancer. This trial will specifically evaluate endurance exercise therapy, such as treadmill walking, as a promising method to manage conditions like adenomatous polyposis.12467
Who Is on the Research Team?
Samara Rifkin
Principal Investigator
University of Michigan Rogel Cancer Center
Are You a Good Fit for This Trial?
This trial is for individuals with familial adenomatous polyposis, a condition that causes many polyps in the intestine. Participants should be able to perform moderate-intensity exercise but specific inclusion and exclusion criteria are not detailed here.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Phase 1a Level-finding
Level escalation trial evaluating 3 exercise levels (150, 225, and 300 minutes per week), with one de-escalation level of 90 minutes per week, if required
Phase 1b Level-expansion
Further evaluation of the highest feasible level and one level below identified in the phase 1a study
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Endurance Exercise Therapy
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Michigan Rogel Cancer Center
Lead Sponsor
National Cancer Institute (NCI)
Collaborator