Study Summary
This trial is testing if anakinra can prevent or reverse the severe side effects of CAR-T cell therapy.
- B-Cell Lymphoma
- B-cell Acute Lymphoblastic Leukemia
- Non-Hodgkin's Lymphoma
Treatment Effectiveness
Phase-Based Effectiveness
Study Objectives
2 Primary · 0 Secondary · Reporting Duration: 28 days from the start of treatment
Trial Safety
Phase-Based Safety
Side Effects for
Awards & Highlights
Trial Design
2 Treatment Groups
Arm 1 (CART Cell Group)
1 of 2
Arm 2 (COVID-19 Group)
1 of 2
Experimental Treatment
62 Total Participants · 2 Treatment Groups
Primary Treatment: Anakinra · No Placebo Group · Phase 2
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 18+ · All Participants · 0 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:- Danish, Husain, and Bianca D. Santomasso. 2021. “Neurotoxicity Biology and Management”. The Cancer Journal. Ovid Technologies (Wolters Kluwer Health). doi:10.1097/ppo.0000000000000507.
- Danish, Husain, and Bianca D. Santomasso. 2021. “Neurotoxicity Biology and Management”. The Cancer Journal. Ovid Technologies (Wolters Kluwer Health). doi:10.1097/ppo.0000000000000507.
- 2019. "A Study of Anakinra to Prevent or Treat Severe Side Effects for Patients Receiving CAR-T Cell Therapy". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04148430.
Frequently Asked Questions
Are there still spots available to participate in this experiment?
"This clinical trial, which was initially posted on October 30th 2019 is still seeking participants. Data hosted on clinicaltrials.gov shows the study has been recently revised as of August 22nd 2022." - Anonymous Online Contributor
In what medical situations is Anakinra typically employed?
"Anakinra is effective at treating systemic juvenile idiopathic arthritis (sjia) and some rarer inflammatory disorders, such as neonatal-onset multisystem inflammatory disease (nomid), receptors, interleukin-1, and steroids." - Anonymous Online Contributor
What other research has been conducted regarding the efficacy of Anakinra?
"In 2016, Anakinra was initially studied at Royal Glamorgan Hospital. Currently, there have been 68 completed trials and 33 experiments in progress; a significant number of these are located in the city of New York." - Anonymous Online Contributor
How hazardous is the use of Anakinra for individuals?
"Anakinra's safety has been partially verified in Phase 2 trials, so it was given a rating of 2. Unfortunately, there is yet to be sufficient evidence regarding its efficacy." - Anonymous Online Contributor
How many participants are being administered treatment in the ongoing research?
"Affirmative. Clinicaltrials.gov records confirm that this trial, first posted on October 30th 2019 and recently updated on August 22nd 2022, is actively recruiting 62 subjects across 2 medical centres." - Anonymous Online Contributor