Complete Revascularization for Heart Attack & Coronary Artery Disease
(COMPLETE-2 Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
COMPLETE-2 is a prospective, multi-centre, randomized controlled trial comparing a strategy of physiology-guided complete revascularization to angiography-guided complete revascularization in patients with acute ST-segment elevation myocardial infarction (STEMI) or non-ST-segment elevation myocardial infarction (NSTEMI) and multivessel coronary artery disease (CAD) who have undergone successful culprit lesion Percutaneous Coronary Intervention (PCI).COMPLETE-2 OCT is a large scale, prospective, multi-centre, observational, imaging study of patients with STEMI or NSTEMI and multivessel CAD in a subset of eligible COMPLETE-2 patients.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is complete revascularization for heart attack and coronary artery disease safe?
How is the treatment Angiography-guided NCL PCI, Physiology-guided NCL PCI different from other treatments for heart attack and coronary artery disease?
This treatment is unique because it involves complete revascularization, which means treating not just the blocked artery causing the heart attack but also other narrowed arteries, using either angiography (imaging) or physiology (blood flow measurement) guidance. This approach has been shown to reduce the risk of future heart problems compared to treating only the blocked artery.678910
What data supports the effectiveness of the treatment Angiography-guided NCL PCI, Angiography-guided Non-culprit Lesion PCI, Angiography-guided NCL PCI, Culprit Lesion–Only PCI, Physiology-guided NCL PCI, Physiology-guided Non-culprit Lesion Complete Revascularization, FFR-Guided Complete Revascularization for heart attack and coronary artery disease?
Who Is on the Research Team?
Shamir Mehta, MD
Principal Investigator
Population Health Research Institute
Are You a Good Fit for This Trial?
This trial is for heart attack patients with multivessel coronary artery disease who've had a successful PCI on the main blockage. They should have additional non-infarct-related artery narrowing and be within 72 hours post-PCI. Excluded are those with planned medical treatment only, life expectancy under 2 years, prior bypass surgery or recent non-culprit lesion PCI, among other factors.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo either physiology-guided or angiography-guided complete revascularization strategies
Observational Study
A subset of patients undergo Optical Coherence Tomography (OCT) imaging
Follow-up
Participants are monitored for cardiovascular outcomes and safety events
What Are the Treatments Tested in This Trial?
Interventions
- Angiography-guided NCL PCI
- Physiology-guided NCL PCI
Angiography-guided NCL PCI is already approved in European Union, United States for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
Population Health Research Institute
Lead Sponsor