<p>Clariscan is a drug that is injected into a vein and used with <a href="https://www.withpower.com/clinical-trials/mri">MRI</a> scans to help doctors better see and understand areas of the brain where there may be problems with the blood-brain barrier.</p>

Clariscan

MRI

Treatment

1 FDA approval

17 Active Studies for Clariscan

Treatment for

MRI

What is Clariscan

Gadoteric acidThe Generic name of this drug

Treatment SummaryGadoteric acid is a contrast agent used in MRI scans to make blood vessels and areas of inflammation or disease more visible. It consists of an organic acid called DOTA and gadolinium, a magnetic element. Gadoteric acid creates a magnetic moment when put in a magnetic field, which then brightens the signal of tissues around it. This drug, sold under the brand name Dotarem, is approved for use in adults and children aged 2 and up for imaging of the brain, spine, and associated tissues. It helps to detect and visualize areas with damaged blood-brain barriers or abnormal blood vessels.

Dotaremis the brand name

Clariscan Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Dotarem

Gadoteric acid

2013

Approved as Treatment by the FDA

Gadoteric acid, also known as Dotarem, is approved by the FDA for 1 uses including MRI .

MRI

Effectiveness

How Clariscan Affects PatientsGadoterate changes how protons respond to MRI signals, which is used to create an image. This drug works the same way with different strength magnetic fields used in clinical MRI. It does not cross the blood-brain barrier, so it cannot be used to image normal brain or lesions with an intact blood-brain barrier. However, if the blood-brain barrier is disrupted or there is abnormal vascularity, gadoterate can be distributed in lesions like tumors, abscesses, and infarcts.

How Clariscan works in the bodyGadoterate is a special molecule that reacts to magnetic fields. When placed in a magnetic field, it creates a magnetic moment that makes nearby water molecules relax faster. This increases the signal intensity of nearby tissues, resulting in brighter images when it is used as a contrast agent.

When to interrupt dosage

The endorsed dosage of Clariscan is dependent on the determined condition. The measure of dosage shifts, as per the mode of application (e.g. Injection - Intravenous or Solution - Intravenous) detailed in the table below.

Condition

Dosage

Administration

MRI

, 376.9 mg/mL

, Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Injection, solution, Injection, solution - Intravenous

Warnings

There are 20 known major drug interactions with Clariscan.

Common Clariscan Drug Interactions

Drug Name

Risk Level

Description

Technetium Tc-99m oxidronate

Major

Gadoteric acid may decrease effectiveness of Technetium Tc-99m oxidronate as a diagnostic agent.

Acrivastine

Minor

Gadoteric acid may decrease the excretion rate of Acrivastine which could result in a higher serum level.

Albutrepenonacog alfa

Minor

Gadoteric acid may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.

Almasilate

Minor

Gadoteric acid may decrease the excretion rate of Almasilate which could result in a higher serum level.

Antihemophilic factor (recombinant), PEGylated

Minor

Gadoteric acid may decrease the excretion rate of Antihemophilic factor (recombinant), PEGylated which could result in a higher serum level.

Clariscan Toxicity & Overdose RiskCommon side effects of GBCAs include nausea, headache, pain, coldness, and burning around the injection site. It is also possible to develop Nephrogenic Systemic Fibrosis, especially in those with impaired kidney function.

Clariscan Novel Uses: Which Conditions Have a Clinical Trial Featuring Clariscan?

10 active trials are exploring the potential of Clariscan as a therapeutic agent for Magnetic Resonance Imaging (MRI) scans.

Condition

Clinical Trials

Trial Phases

MRI

17 Actively Recruiting

Phase 2, Not Applicable, Phase 3

Patient Q&A Section about clariscan

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the CPT code for Clariscan?

"Gadoterate meglumine injection can be billed using HCPCS code A9575. Guidelines for billing this code can be found on the NC Medicaid website."

Answered by AI

What class is Clariscan?

"Clariscan is a drug that helps create pictures of the inside of your body during an MRI scan. It belongs to a class of drugs called Diagnostic Imaging Agents."

Answered by AI

Are Clariscan and Dotarem the same?

"A new macrocyclic GBCA, Clariscan, has become available in some countries. This GBCA has the same formulation as Dotarem, but has never been included in either clinical or non-clinical studies of Gd retention."

Answered by AI

What is a Clariscan?

"Clariscan is a drug that is injected into a vein and used with MRI scans to help doctors better see and understand areas of the brain where there may be problems with the blood-brain barrier."

Answered by AI

Clinical Trials for Clariscan

Have you considered Clariscan clinical trials? We made a collection of clinical trials featuring Clariscan, we think they might fit your search criteria.

Have you considered Clariscan clinical trials? We made a collection of clinical trials featuring Clariscan, we think they might fit your search criteria.