Wake Training + TMR for Sleep Apnea
Trial Summary
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It might be best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of the treatment Wake training + TMR for sleep apnea?
Inspiratory muscle training (IMT), a component of the treatment, has been shown to improve inspiratory muscle strength, sleep quality, and reduce daytime sleepiness in people with obstructive sleep apnea (OSA). Additionally, orofacial myofunctional reeducation (OMR), another similar therapy, has been effective in reducing the severity of OSA and improving sleep quality.12345
Is Wake Training + TMR for Sleep Apnea safe for humans?
How is the Wake Training + TMR treatment for sleep apnea different from other treatments?
Wake Training + TMR is unique because it combines wake training, which may involve exercises to improve muscle function, with targeted memory reactivation (TMR) during sleep. This approach is different from traditional treatments like CPAP (continuous positive airway pressure) machines, as it focuses on training and potentially enhancing the body's natural ability to maintain open airways during sleep.29101112
What is the purpose of this trial?
This study will examine whether a combination of breathing training during wake and targeted reactivation of the training during sleep can induce breathing changes during sleep and subsequent cognitive benefits during wake.Participants with obstructive sleep apnea (who have not yet been treated for sleep apnea) will be recruited. Participants will engage in breath training for one week in their own homes and to record their sleep at home using commercially available mobile devices and subsequently have their sleep monitored for one night of polysomnography recordings plus targeted reactivation in a laboratory setting.
Research Team
Ken A Paller, PhD
Principal Investigator
Northwestern University
Eligibility Criteria
This trial is for individuals with untreated obstructive sleep apnea. Participants will practice breath training at home for a week and have their sleep recorded using mobile devices, followed by one night of detailed sleep study in a lab.Inclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Breath Training
Participants engage in breath training for one week in their own homes and record their sleep using mobile devices
Polysomnography and Targeted Reactivation
Participants have their sleep monitored for one night of polysomnography recordings plus targeted reactivation in a laboratory setting
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Wake training + TMR
Find a Clinic Near You
Who Is Running the Clinical Trial?
Northwestern University
Lead Sponsor