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Brachytherapy

Partial Breast Irradiation for Breast Cancer (PBSI Trial)

N/A
Waitlist Available
Led By Juanita Crook, MD
Research Sponsored by British Columbia Cancer Agency
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age greater than 55 years and postmenopausal
Histology must be either Ductal Carcinoma In Situ or invasive ductal adenocarcinoma of the breast
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 5 years
Awards & highlights

PBSI Trial Summary

This trial is investigating a new form of breast cancer radiation treatment that is less toxic and more affordable than current methods.

Who is the study for?
This trial is for postmenopausal women over 55 with early-stage breast cancer (Stage 0 or I, tumor <2cm) that's been surgically removed with clear margins. Participants must have a life expectancy of at least ten years and cannot have had certain other cancers unless disease-free for five years. Those with genetic mutations in BRCA, high-grade tumors, unclear surgical sites, or previous chest radiotherapy are excluded.Check my eligibility
What is being tested?
The study tests a type of partial breast radiation therapy using Palladium-103 seed implants after lumpectomy in patients with specific types of breast cancer. It aims to refine the technique and gather data on its side effects and costs compared to other treatments.See study design
What are the potential side effects?
While not explicitly listed here, typical side effects from similar radiation therapies may include skin changes like redness or irritation at the treatment site, fatigue, discomfort or pain around the implant area, and potential short-term swelling.

PBSI Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am over 55 years old and have gone through menopause.
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My breast cancer is either DCIS or invasive ductal adenocarcinoma.
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My lumpectomy cavity is less than 3 cm across and can be seen clearly on scans.
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My cancer is low or intermediate grade.
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I had or will have brachytherapy within 4 months after my last breast surgery.
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I have been cancer-free for 5 years, except for certain skin cancers or early-stage cervical or colon cancer.
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My tumor is positive for estrogen receptors.
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My tumor was completely removed with surgery and the edges were cancer-free.
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My doctor agrees I can have a specific breast cancer treatment involving seed implants.
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My condition involves only one area or organ.
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My breast cancer is in the early stages and the tumor is smaller than 2 cm.
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I had a procedure to check lymph nodes in my armpit for breast cancer.

PBSI Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Implant quality
Secondary outcome measures
Cosmesis
Cost
Dose to Organs at risk
+4 more

PBSI Trial Design

1Treatment groups
Experimental Treatment
Group I: Breast seed implantExperimental Treatment3 Interventions
Stranded palladium seed interstitial radioactive seed implant to seroma with margin with 3 dimensional ultrasound and CT guidance

Find a Location

Who is running the clinical trial?

British Columbia Cancer AgencyLead Sponsor
171 Previous Clinical Trials
90,436 Total Patients Enrolled
18 Trials studying Breast Cancer
7,986 Patients Enrolled for Breast Cancer
Juanita Crook, MDPrincipal InvestigatorBritish Columbia Cancer Agency
4 Previous Clinical Trials
878 Total Patients Enrolled

Media Library

Stranded Palladium Seed Interstitial Implant (Brachytherapy) Clinical Trial Eligibility Overview. Trial Name: NCT02297672 — N/A
Breast Cancer Research Study Groups: Breast seed implant
Breast Cancer Clinical Trial 2023: Stranded Palladium Seed Interstitial Implant Highlights & Side Effects. Trial Name: NCT02297672 — N/A
Stranded Palladium Seed Interstitial Implant (Brachytherapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT02297672 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this research accept individuals aged 40 or over as participants?

"This clinical trial is only open to applicants between the ages of 55 and 80. Conversely, there are 64 separate trials for individuals under 18 years old and 2208 tests available for those over 65 years old."

Answered by AI

Would I be eligible to join this clinical investigation?

"Qualified participants for this medical trial must between the ages of 55 and 80, with a diagnosis of breast cancer. Currently, 75 potential patients are being sought out."

Answered by AI

What is the current availability of patient slots in this research project?

"The clinical trial as listed on clinicaltrials.gov is not currently recruiting patients, despite having been initially published in February 2015 and updated in March 2022. Nevertheless, over 2290 other studies are actively seeking out participants at this time."

Answered by AI
Recent research and studies
~7 spots leftby Apr 2025