Desogen

Birth Control, Hormonal Contraception
Treatment
20 Active Studies for Desogen

What is Desogen

DesogestrelThe Generic name of this drug
Treatment SummaryDesogestrel is a drug used in combination with Ethinyl Estradiol to treat certain medical conditions. It is a synthetic version of a naturally occurring plant steroid, and was first developed and approved in the U.S. in 1992 by Organon USA Inc. Desogestrel is a third generation progestogen, meaning it works by blocking the body's natural hormones to help with certain conditions.
Desogenis the brand name
image of different drug pills on a surface
Desogen Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Desogen
Desogestrel
1992
68

Effectiveness

How Desogen Affects PatientsDesogestrel is used to modify the hormones in the reproductive system, delaying the onset of menstruation and thickening the vaginal fluid. It can also increase insulin secretion and resistance, and increase fat storage in the body. The main therapeutic effect of desogestrel is that it prevents ovulation 97% of the time. However, it can also increase the risk of blood clots and thromboembolism. On the other hand, desogestrel does not make much of a difference to total cholesterol levels, as it only causes a change of 10% or less.
How Desogen works in the bodyDesogestrel enters cells and binds to a type of receptor that responds to progesterone. This binding is like a switch that changes the cell's instructions, which can lead to different kinds of effects. The active form of desogestrel, etonogestrel, is especially good at producing a progesterone-like effect while having low levels of androgen.

When to interrupt dosage

The proposed dose of Desogen is contingent upon the diagnosed condition, including Birth Control, Nursing Women and Hormonal Contraception. The dosage fluctuates, based on the delivery strategy (e.g. Kit or Kit; Tablet - Oral) detailed in the table below.
Condition
Dosage
Administration
Birth Control
, 0.15 mg, 0.1 mg, 0.125 mg, 0.375 mg
, Kit, Oral, Tablet - Oral, Tablet, Kit - Oral
Hormonal Contraception
, 0.15 mg, 0.1 mg, 0.125 mg, 0.375 mg
, Kit, Oral, Tablet - Oral, Tablet, Kit - Oral

Warnings

Desogen has twenty-five contraindications and should not be employed when having any of the conditions outlined in the subsequent table.Desogen Contraindications
Condition
Risk Level
Notes
Stroke
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Liver Cancer
Do Not Combine
Endometrial Neoplasms
Do Not Combine
Thromboembolism
Do Not Combine
Thromboembolism
Do Not Combine
Major Surgery
Do Not Combine
benign hepatic adenoma
Do Not Combine
Breast Cancer
Do Not Combine
Liver Diseases
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
Breast
Do Not Combine
Type 2 Diabetes
Do Not Combine
Coronary Disease
Do Not Combine
Thrombophlebitis
Do Not Combine
Thrombophilia
Do Not Combine
Diastolic blood pressure
Do Not Combine
Hypertension
Do Not Combine
Jaundice, Obstructive
Do Not Combine
Venous Thrombosis
Do Not Combine
Icterus
Do Not Combine
focal neurological symptoms
Do Not Combine
Heart Valve Diseases
Do Not Combine
estrogen-dependent neoplasia
Do Not Combine
There are 20 known major drug interactions with Desogen.
Common Desogen Drug Interactions
Drug Name
Risk Level
Description
Axitinib
Major
The metabolism of Axitinib can be increased when combined with Desogestrel.
Belinostat
Major
The metabolism of Belinostat can be increased when combined with Desogestrel.
Binimetinib
Major
The metabolism of Binimetinib can be increased when combined with Desogestrel.
Enasidenib
Major
The metabolism of Enasidenib can be increased when combined with Desogestrel.
Etoposide
Major
The metabolism of Etoposide can be increased when combined with Desogestrel.
Desogen Toxicity & Overdose RiskTaking a lot of desogestrel has been found to cause strong hormonal effects, but not long-term damage. The highest toxic dose for rats is higher than 2000mg/kg. Taking too much of this drug may cause nausea or stop menstruation, but it does not seem to raise the risk of breast cancer. Some studies have suggested that desogestrel may lead to cell changes in the cervix, but the results are not certain.

Desogen Novel Uses: Which Conditions Have a Clinical Trial Featuring Desogen?

38 active trials are currently underway to evaluate the potential of Desogen for Nursing Women, Birth Control and Hormonal Contraception.
Condition
Clinical Trials
Trial Phases
Birth Control
22 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Early Phase 1, Phase 2
Hormonal Contraception
0 Actively Recruiting

Desogen Reviews: What are patients saying about Desogen?

5Patient Review
4/26/2016
Desogen for Disease of Ovaries with Cysts
I've tried a few different kinds of birth control in the past, but I've been on this one for three months. I had a really bad reaction to the NUVARING, so this has been a great alternative. The hardest thing is remembering to take it every day, but other than that I haven't had any issues.
4Patient Review
1/12/2012
Desogen for Birth Control
The first week was difficult as I felt nauseous all the time. For the next three weeks, my mood swings were really bad and I had no patience for anyone, especially my two-year-old child. By the second week, I also started having digestive problems like diarrhea and irregular bowel movements. Thankfully, I'm on the one-week break now and feeling much better.
4Patient Review
4/20/2011
Desogen for Disease of Ovaries with Cysts
I've been taking Desogen on and off for 15 years now. I started up again in June 2010 but then developed non-stop bleeding that lasted for six weeks. This is the only time I have ever had problems with the drug. I'm no longer taking it per my doctor's instructions.
4Patient Review
1/11/2011
Desogen for Birth Control
Bloating and farting after eating were both immediately relieved after starting this medication. I only take it at night to avoid nausea, but that's been manageable. After just one month, I've already seen a significant difference.
4Patient Review
3/19/2014
Desogen for Birth Control
Though this was effective in preventing pregnancy, I experienced some significant side effects that made it difficult to justify taking the medication. In addition to gaining weight, I felt tired all the time. The one upside was that my hormonal acne around my chin cleared up.
4Patient Review
5/10/2012
Desogen for Disease of Ovaries with Cysts
I've been feeling very moody lately. One minute I'm happy and the next I'm angry. My bleeding is still heavy and I'm dealing with a lot of bloating.
3.3Patient Review
9/16/2013
Desogen for Birth Control
When I first started taking this drug, I was on it for two months straight. It was fine except that I felt suicidal the whole time. So, I took a month break and now I've been back on it for about a month and it's awful. In the last two weeks, I've gained 10 pounds (even though I only eat once a day and have a very active job). Plus, I'm nauseous in the morning, sad or angry most of the day, and sluggish.
3Patient Review
11/14/2012
Desogen for Birth Control
I haven't been feeling like myself since starting this medication. My emotions are all over the place and I've been short-tempered and snippy. It's put a damper on my sex life and I just don't have the same energy levels.
3Patient Review
11/10/2013
Desogen for Birth Control
I first started noticing the headaches. Then, my period lasted for three weeks without any respite. In addition, my breasts have been sensitive and I get tired really easily. There are also times when I'll suddenly become very horny or very turned off for no apparent reason.
3Patient Review
3/17/2012
Desogen for Birth Control
Though there was no risk of pregnancy with this treatment, it killed my sex drive, caused breakouts, and left me feeling fairly depressed.
1Patient Review
11/25/2014
Desogen for Birth Control
I had a stroke because of this medicine. Please be very careful and research all potential side effects before taking any medication.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about desogen

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the generic name for Desogen?

"- Desogen (desogestrel / ethinyl estradiol) is a birth control pill. It is a combination of two hormones, desogestrel and ethinyl estradiol, that prevents ovulation (the release of an egg from the ovary).

Desogen (desogestrel / ethinyl estradiol) is a birth control pill that contains a combination of two hormones, desogestrel and ethinyl estradiol. These hormones work together to prevent ovulation, which is the release of an egg from the ovary."

Answered by AI

What is Desogen used for?

"This medication, which contains a combination of two hormones (a progestin and an estrogen), is used to prevent pregnancy. In addition to preventing pregnancy, birth control pills may also make your periods more regular, decrease blood loss and painful periods, decrease your risk of ovarian cysts, and treat acne."

Answered by AI

What kind of birth control is Desogen?

"Desogen is a prescription medicine that can be used as contraception to prevent pregnancy. It may be used alone or with other medications."

Answered by AI

Does Desogen cause weight gain?

"Some women report gaining weight when they start taking Desogen, along with other birth control pills, but there is no evidence that the pill causes dramatic changes in weight."

Answered by AI

Clinical Trials for Desogen

Image of University of California, San Diego in La Jolla, United States.

Lidocaine for Pain Control in Birth Control

18 - 50
Female
La Jolla, CA
The goal of this research study is to learn more about how different uses of a numbing medication might affect pain levels while getting an IUD placed. The investigators are also studying participants opinions of their clinicians' empathy. The investigators are inviting patients who arrive at their clinic visit seeking an IUD. Usually, at University of California, San Diego (UCSD), for patients who have never delivered a baby, clinicians use a buffered paracervical block for before IUD placement. The purpose of this research study is to investigate whether a "buffered" (2 cc of sodium bicarbonate, 18 cc of 1% lidocaine) paracervical block (numbing medication given on both sides of the cervix) is effective in reducing pain during IUD placement in individuals with prior C-sections, the difference between buffered and unbuffered for nulliparous patients, and whether a medicated gel reduces pain with the paracervical block.
Recruiting
Paid Trial
University of California, San DiegoSheila K Mody, MD, MPH
Image of EmpoweRx, Inc in Del Mar, United States.

HAPPI Software for Birth Control Access

18+
All Sexes
Del Mar, CA
The goal of this clinical trial is to learn if use of the HAPPI software can improve pharmacist-provided birth control services. The main questions it aims to answer are: 1. Does the HAPPI software make it easier for pharmacists to provide birth control services in their pharmacy? 2. Does the HAPPI software make it easier for patients to access birth control? Researchers will compare pharmacists' implementation and patients' access when using the HAPPI software and when not using the HAPPI software to see if the software improves implementation and access. Participants will include pharmacists and patients. Pharmacists will be asked to provide birth control services as normal while using the HAPPI software. Patients will be asked to receive birth control services from a pharmacist as normal, while using the HAPPI software.
Recruiting
Has No Placebo
EmpoweRx, Inc
Image of Calabasas Pharmacy in Calabasas, United States.

Electronic Health Record Platform for Birth Control

18 - 51
Female
Calabasas, CA
Hormonal contraceptives are medications that require a prescription, traditionally from a physician or advanced practice provider. Over the past decade, pharmacists have gained the authority to prescribe contraceptives in many states, allowing patients to access these medications directly in pharmacies without first seeing another healthcare provider. The Pharmacist Resource to Implement Services as Modules (PRISM) is an Electronic Health Record platform designed to streamline workflows and provide clinical decision support, making it easier and safer to deliver clinical services in community pharmacies. This pilot study will evaluate patient-reported outcomes for women receiving contraceptive services from pharmacists using the PRISM platform at five community pharmacies across the United States over a 12-week period. The study will assess the quality of care, contraception continuation and failure rates, side effect rates, preventative healthcare utilization, and overall patient experience with pharmacy contraceptive services.
Waitlist Available
Has No Placebo
Calabasas Pharmacy (+4 Sites)OvaryIt, LLC
Have you considered Desogen clinical trials? We made a collection of clinical trials featuring Desogen, we think they might fit your search criteria.Go to Trials
Image of Jackson State University/Department of Behavioral & Environmental Health in Jackson, United States.

PEN-3 Intervention for Postpartum Depression

18 - 45
Female
Jackson, MS
Maternal mortality in the United States is higher than in peer nations and has not decreased since 1990. Beyond mortality, severe maternal mortality impacts far too many women. Not only are these high rates alarming, but notable racial/ethnic and socioeconomic disparities exist. These inequities are highly regional, with women living in the rural southeast part of the United States, including the Mississippi Delta, having the highest rates of maternal mortality and morbidity. Unfortunately, these disparities have proven to be stubbornly resistant to interventions, necessitating an innovative multifaceted approach focused on community practice, building trust, and prioritizing patient voices. To meet this need, this proposal aims to establish the Mississippi Delta Research Center of Excellence for Maternal Health with the goal of addressing preventable maternal mortality, decreasing severe maternal morbidity, and promoting maternal health equity in partnership with the Mississippi Delta community. This patient-clinical linkages intervention study will evaluate the effectiveness of a multilevel and multisector communication and health literacy strategy to increase trust and engagement in postpartum healthcare among women in the Mississippi Delta, with a specific focus on Black women, their families, and their communities. These research projects both have the overarching goal of partnering with the community to determine and meet the needs of pregnant and postpartum women in the Mississippi Delta and address the disparities within maternity health and health care outcomes.
Recruiting
Has No Placebo
Jackson State University/Department of Behavioral & Environmental HealthMary Shaw, PhD
Image of University of Colorado Anschutz Medical Campus in Aurora, United States.

Birth Control Pills and DNA Interaction

18 - 45
Female
Aurora, CO
The goal of this clinical trial is to evaluate how differences in specific parts of our DNA can influence how individual bodies break down the hormones contained within oral contraceptive pills, which could affect how well these birth control pills work to prevent pregnancy. The investigators are also interested in exploring how these differences in our DNA can also explain why patients taking the exact same formulation of birth control pill will experience very different side effects. The main questions it aims to answer are: * Do individuals with the CYP3A7\*1C variant have increased metabolism of both desogestrel and ethinyl estradiol when taking a combined oral contraceptive pill? * Do individuals with the CYP3A7\*1C variant experience higher rates of breakthrough ovulation while taking a desogestrel/ethinyl estradiol combined oral contraceptive pill? * What novel genetic loci are associated with alterations in steroid hormone pharmacokinetics and pharmacodynamics among a larger cohort of combined oral contraceptive pill users? Participants will take a specific formulation of combined oral contraceptive pill (desogestrel/ethinyl estradiol) and undergo the following procedures: * Blood draw to measure the amount of progestin and estrogen in their system from the combined oral contraceptive pill * Questionnaires to assess side effects possibly caused by the combined oral contraceptive pill * Blood draw to measure endogenous hormone levels and biomarkers that may be affected by the combined oral contraceptive pill * A transvaginal ultrasound to measure any ovarian follicles (optional procedure)
Phase 4
Recruiting
University of Colorado Anschutz Medical Campus (+2 Sites)Aaron M Lazorwitz, MD, PhD
Have you considered Desogen clinical trials? We made a collection of clinical trials featuring Desogen, we think they might fit your search criteria.Go to Trials
Image of Greater Boston Health Center in Boston, United States.

SBIRT for Alcohol and Substance Use Disorders

18+
All Sexes
Boston, MA
The goal of this clinical trial is to test the effectiveness of evidence-based Screening, Brief Intervention, and Referral to Treatment (SBIRT) among adult patients who screen positive to one or more risky alcohol or substance use behaviors while seeking care at a sexual and reproductive health (SRH) clinic. The main questions it aims to answer are: * Does SBIRT impact patients' alcohol and substance use, SRH, mental health, physical health, quality of life, and wellbeing? * Does SBIRT effectiveness differ by ethnicity, socioeconomic status, age, gender, and urbanicity? * Does SBIRT effectiveness differ by delivery mode (in-person vs. telemedicine)? Participants will receive in-person and telemedicine SBIRT, or usual care. Participants will complete surveys at interviews at baseline, 30 days, and 3 months. Researchers will compare patients who received SBIRT to patients who receive usual care to see if patients who receive the SBIRT intervention have a greater reduction in negative outcomes as compared to those who receive usual care. In this setting, usual care consists of basic quantity and frequency questions asked inconsistently as part of the admission process and varying by provider, with no standardized approach to screening, treatment, follow-up, or referral.
Recruiting
Has No Placebo
Greater Boston Health Center (+3 Sites)Kelli S Hall, MD
Image of OHSU in Portland, United States.

Progestin Contraceptives for Birth Control Effects

18 - 40
Female
Portland, OR
The purpose of the study is to learn more about menstrual changes in progestin contraception users. The investigators are hoping to find out what changes in the endometrium lead to different bleeding patterns during the first year of progestin contraception use. Participants will choose to receive the contraceptive implant (Etonogestrel implant also called Nexplanon) or the contraceptive injectable (Depo-medroxyprogesterone acetate (DMPA) also called Depo-Provera) for up to 12 months. They will be asked to have 4 endometrial biopsies over the course of the study, as well as blood draws, physical exams, and pregnancy tests. Participants will also use a daily text message or email diary to report bleeding patterns. This study's plan is to comprehensively phenotype bleeding patterns and profile the entire endometrium using single-cell RNA seq data (sCRNAseq).
Phase < 1
Recruiting
OHSUAlison Edelman, MD
Have you considered Desogen clinical trials? We made a collection of clinical trials featuring Desogen, we think they might fit your search criteria.Go to Trials
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