Tri-Previfem

Acne Vulgaris, moderate Vulvovaginal atrophy, Hot flashes + 9 more
Treatment
9 FDA approvals
20 Active Studies for Tri-Previfem

What is Tri-Previfem

NorgestimateThe Generic name of this drug
Treatment SummaryEthinylestradiol was developed in 1938 by Hans Herloff Inhoffen and Walter Hohlweg at the Schering company. It was created to be a more effective form of estrogen with higher availability when taken orally. Ethinylestradiol is now used in many contraceptive pills and was approved by the FDA in 1943.
Ortho Tri Cyclenis the brand name
image of different drug pills on a surface
Tri-Previfem Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ortho Tri Cyclen
Norgestimate
1989
113

Approved as Treatment by the FDA

Norgestimate, commonly known as Ortho Tri Cyclen, is approved by the FDA for 9 uses which include Postmenopausal Osteoporosis and severe menopausal vulvovaginal atrophy .
Postmenopausal Osteoporosis
Used to treat Postmenopausal Osteoporosis in combination with Estradiol
severe menopausal vulvovaginal atrophy
Used to treat severe menopausal vulvovaginal atrophy in combination with Estradiol
Oral Contraceptives
Used to treat Oral Contraceptives in combination with Ethinylestradiol
Acne Vulgaris
Used to treat moderate Acne vulgaris in combination with Ethinylestradiol
Osteoporosis, Postmenopausal
Used to treat Postmenopausal Osteoporosis in combination with Estradiol
moderate Vulvovaginal atrophy
Used to treat moderate Vulvovaginal atrophy in combination with Estradiol
Hot flashes
Used to treat Menopause in combination with Estradiol
moderate Menopausal Vasomotor Symptoms
Used to treat moderate Menopausal Vasomotor Symptoms in combination with Estradiol
Menopause
Used to treat severe Vasomotor Symptoms Associated With Menopause in combination with Estradiol

Effectiveness

How Tri-Previfem Affects PatientsEthinylestradiol is a synthetic version of the hormone estrogen. It helps reduce luteinizing hormone and gonadotrophic hormone levels in the body, which can reduce the growth of the lining of the womb and prevent ovulation. It is taken once a day and is considered to be a relatively safe drug, though patients should be aware of the risk of blood clotting.
How Tri-Previfem works in the bodyEthinylestradiol is a synthetic hormone that is used in combined oral contraceptives. It works by blocking the hormones that cause ovulation, making it harder for sperm to travel, and preventing changes in the uterus that allow for pregnancy. It also decreases luteinizing hormone levels, which lowers the amount of blood flow to the uterus. Lastly, it increases the amount of a protein (sex hormone binding globulin) that binds to hormones and stops them from working.

When to interrupt dosage

The measure of Tri-Previfem is contingent upon the diagnosed condition, including Acne Vulgaris, Hormonal Contraception and Folate supplementation therapy. The quantity of dosage fluctuates as per the technique of delivery as outlined in the table beneath.
Condition
Dosage
Administration
Polycystic Ovarian Syndrome
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
Kit, , Oral, Tablet, Tablet - Oral, Kit - Oral
moderate Vulvovaginal atrophy
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
Kit, , Oral, Tablet, Tablet - Oral, Kit - Oral
severe menopausal vulvovaginal atrophy
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
Kit, , Oral, Tablet, Tablet - Oral, Kit - Oral
Menopause
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
Kit, , Oral, Tablet, Tablet - Oral, Kit - Oral
Osteoporosis, Postmenopausal
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
Kit, , Oral, Tablet, Tablet - Oral, Kit - Oral
Oral Contraceptives
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
Kit, , Oral, Tablet, Tablet - Oral, Kit - Oral
Menorrhagia
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
Kit, , Oral, Tablet, Tablet - Oral, Kit - Oral
Hirsutism
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
Kit, , Oral, Tablet, Tablet - Oral, Kit - Oral
moderate Menopausal Vasomotor Symptoms
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
Kit, , Oral, Tablet, Tablet - Oral, Kit - Oral
Hot flashes
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
Kit, , Oral, Tablet, Tablet - Oral, Kit - Oral
Acne Vulgaris
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
Kit, , Oral, Tablet, Tablet - Oral, Kit - Oral
Dysmenorrhea
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
Kit, , Oral, Tablet, Tablet - Oral, Kit - Oral

Warnings

Tri-Previfem has twenty-six contraindications and should not be consumed by those experiencing any of the conditions in the following table.Tri-Previfem Contraindications
Condition
Risk Level
Notes
Breast
Do Not Combine
Breast Cancer
Do Not Combine
high risk of arterial thrombotic disease
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Hypersensitivity
Do Not Combine
Venous Thrombosis
Do Not Combine
Pulse Frequency
Do Not Combine
estrogen-sensitive cancer
Do Not Combine
Metrorrhagia
Do Not Combine
Liver Neoplasms
Do Not Combine
There are 20 known major drug interactions with Tri-Previfem.
Common Tri-Previfem Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Norgestimate.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Norgestimate.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Norgestimate.
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Norgestimate.
Astemizole
Major
The metabolism of Astemizole can be increased when combined with Norgestimate.
Tri-Previfem Toxicity & Overdose RiskWomen who overdose on birth control may have symptoms such as bleeding, nausea, vomiting, breast tenderness, abdominal pain, drowsiness, and fatigue. Treatment for this should include monitoring potassium and sodium levels in the body, as well as signs of acidosis, and providing supportive care.
image of a doctor in a lab doing drug, clinical research

Tri-Previfem Novel Uses: Which Conditions Have a Clinical Trial Featuring Tri-Previfem?

38 active studies are currently assessing the potential of Tri-Previfem to provide Folate supplementation therapy, alleviate Premenstrual Dysphoric Disorder and manage Menopause-related symptoms.
Condition
Clinical Trials
Trial Phases
Dysmenorrhea
1 Actively Recruiting
Not Applicable
Acne Vulgaris
0 Actively Recruiting
Osteoporosis, Postmenopausal
0 Actively Recruiting
Oral Contraceptives
1 Actively Recruiting
Not Applicable
Menopause
0 Actively Recruiting
Polycystic Ovarian Syndrome
6 Actively Recruiting
Not Applicable, Phase 1
moderate Menopausal Vasomotor Symptoms
0 Actively Recruiting
Hirsutism
0 Actively Recruiting
Hot flashes
19 Actively Recruiting
Not Applicable, Phase 4, Phase 2, Early Phase 1, Phase 3
moderate Vulvovaginal atrophy
0 Actively Recruiting
Menorrhagia
3 Actively Recruiting
Phase 1, Phase 2, Not Applicable
severe menopausal vulvovaginal atrophy
0 Actively Recruiting

Tri-Previfem Reviews: What are patients saying about Tri-Previfem?

5Patient Review
2/25/2016
Tri-Previfem for Birth Control
This birth control has been my saving grace. I was on other pills before that gave me cramps, made my period irregular, and left me feeling emotionally out of balance; none of those problems exist now.
5Patient Review
8/24/2017
Tri-Previfem for Birth Control
I've been using this birth control for four years now, and it's never let me down. It cleared up my acne, made my boobs grow, and I haven't had any problems with it.
5Patient Review
5/2/2018
Tri-Previfem for Abnormal Bleeding from the Uterus
I can't speak highly enough of this medication for girls who have painful or long periods. This has been an absolute lifesaver for me and I haven't had to go to the ER once since starting it.
4.3Patient Review
5/4/2020
Tri-Previfem for Acne
I've been on the pill for a few months now, and it's done wonders for my acne. My skin is completely clear, and I haven't had a pimple in weeks. However, I have gained some weight and my breasts have gotten slightly bigger, which isn't ideal. I'm really stressed about the weight gain because I never had issues with my weight before.
4Patient Review
3/21/2016
Tri-Previfem for Birth Control
This treatment was effective in preventing pregnancy, but it came with some serious side effects. I became an emotional wreck, crying at everything and getting extremely moody. My stomach pains were horrible, and the headaches were constant. I would not recommend this to anyone unless you are prepared to deal with some very unpleasant symptoms.
3.7Patient Review
2/15/2019
Tri-Previfem for Acne
I've been taking this for two months now. I came from Loryana in hopes of finding something more effective for my acne, and so far this has done wonders for clearing up my skin. The only downside is that I feel like I'm gaining weight and my stomach always looks bloated.
3.3Patient Review
11/7/2021
Tri-Previfem for Premenstrual Disorder with a State of Unhappiness
Though this pill did prevent pregnancy, I gained weight and experienced changes in mood that left me feeling very unhappy.
3Patient Review
12/30/2016
Tri-Previfem for Birth Control
I've found that the other commentators are accurate in their assessment of this treatment. It gives you headaches, your boobs grow but are incredibly tender for months, and you become moody and irritable. My boyfriend thinks I should stop taking it, but other research shows that the alternative treatments can cause cancer to activate and be 10 times worse. So hopefully I'll get less bitchy and psycho when I reach my one year mark. Good luck!
1.7Patient Review
3/14/2019
Tri-Previfem for Premenstrual Disorder with a State of Unhappiness
I had a really bad experience with this medicine. I was shaking all over, couldn't grab my cup, and couldn't sleep. I also had sharp abdominal pain and mood swings.
1Patient Review
1/29/2019
Tri-Previfem for Birth Control
Do not under any circumstances take this pill. It caused me severe anxiety and panic attacks for no reason, abdominal pain, diarrhea, weight gain, burning skin, and rashes all over my body.
1Patient Review
5/23/2016
Tri-Previfem for Birth Control
This pill was a complete disaster for me. Not only did it fail to prevent pregnancy, but it also caused me to gain 30lbs, go from a DD to an H cup, and suffer from panic attacks and depression. On top of all that, the physical changes it made to my body (and my voice) practically ruined my singing career. Thank you Tri Previfem, for ruining my life!
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about tri-previfem

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What kind of birth control is tri-Previfem?

"This pill contains a combination of progestin and estrogen which prevents pregnancy by making your body think it is already pregnant."

Answered by AI

What is the generic name for Tri-Previfem?

"Ortho Tri-Cyclen Lo is a birth control pill that is taken once a day, at the same time every day, for 21 days straight. Then, one dark green pill is taken daily for 7 days."

Answered by AI

Is Tri-Previfem the same as Tri Sprintec?

"There are several generic brands of Tri-Sprintec that are quite affordable if you choose to pay out-of-pocket. These include Trinessa, Tri-Estarylla, Tri-Previfem, Tri Norgestimate ethinyl estradiol or Tri-Linyah."

Answered by AI

Is Tri-Previfem still available?

"is the most recent update on this drug. Ortho Cyclen has been discontinued and if there are any generic equivalents, they will be available."

Answered by AI

Clinical Trials for Tri-Previfem

Image of Erevna Innovations Inc. in Montreal, Canada.

Sculptra + Restylane for Post-Menopausal Skin Concerns

40 - 65
Female
Montreal, Canada
The post-menopausal state is marked by a sharp decline in estrogen, leading to significant structural and functional changes in the skin, including collagen loss, dryness, thinning, and reduced elasticity. To address these concerns, aesthetic injectables products such as Sculptra® Aesthetic (poly-L-lactic-acid \[PLLA- SCA\]) and Restylane Skinboosters®\[HASBV\] (small-particle hyaluronic acid - SP-HA) can be used. PLLA-SCA stimulates collagen production via cellular activation (biostimulator), gradually improving dermal structure. HASBV enhances hydration, elasticity, and skin texture when injected under the skin. Considering that hydration and laxity represent the primary aesthetic concerns in this patient population. Targeted treatment with SP-HA (HASBV) to improve hydration and PLLA-SCA to address laxity have been shown to produce significant clinical outcomes by directly addressing these key dermal deficiencies. This approach forms the basis of the current study.
Phase 4
Recruiting
Erevna Innovations Inc.Andreas Nikolis, MD, PhD
Image of Center for Human Nutrition in Fayetteville, United States.

Higher Protein Diet for PCOS

18 - 50
Female
Fayetteville, AR
Polycystic ovary syndrome (PCOS) is a significant public health problem and is one of the most common hormonal disturbances affecting women of reproductive age. Women with PCOS are often insulin resistant, increasing their risk for cardiometabolic health problems (e.g., type 2 diabetes, heart disease, high blood pressure, sleep apnea, anxiety, depression, and stroke) especially if they are overweight. Lifestyle modifications, including dietary changes and regular physical activity, may alleviate metabolic dysfunction in women with PCOS and are often the first line of management for patients with PCOS. Several studies have identified protein as a key nutrient for regulation of energy balance, maintenance of skeletal muscle mass, and improving cardiometabolic health across the lifespan. However, the effect of increased protein intake (30% of total energy intake) on cardiometabolic health in women with PCOS has not been well-defined and mechanisms for these effects have not been identified. There is an evident need for well-designed, randomized controlled trials evaluating the efficacy of increased protein intake in women with PCOS on markers of cardiometabolic health. Preliminary data from collaborative projects with the investigators on this proposal suggest that increasing protein in the diet has the potential to improve markers of cardiometabolic health, potentially through improvements in body composition and/or changes in cortisol, energy metabolism, inflammation, and neurological regulators
Recruiting
Has No Placebo
Center for Human Nutrition
Image of Center for Human Nutrition in Fayetteville, United States.

Protein Meals for Polycystic Ovary Syndrome

18 - 50
Female
Fayetteville, AR
Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by insulin resistance, hyperandrogenism, and reproductive dysfunction. Dietary strategies that improve postprandial insulin and glucose responses are central to managing metabolic symptoms in PCOS. Meals higher in protein can attenuate postprandial glycemia and enhance satiety, but the effects may vary by protein source. Animal sources of protein typically have higher essential amino acid content and insulinogenic potential, whereas plant proteins offer fiber and phytochemicals that may influence glycemic dynamics differently. Few studies have directly compared the acute metabolic effects of plant versus animal protein in women with PCOS. Given the distinct pathophysiology of PCOS, extrapolating findings from healthy populations may be misleading. Understanding protein-specific effects on postprandial insulin, glucose, and appetite-regulating hormones in this group is essential for targeted nutrition guidance. Additionally, plant-based diets are increasingly promoted for cardiometabolic health, but their acute effects in insulin-resistant women remain underexplored. This study will assess whether plant and animal protein meals elicit differential postprandial responses in women with PCOS. Findings may inform dietary recommendations aimed at improving metabolic outcomes in this high-risk population.
Recruiting
Has No Placebo
Center for Human NutritionJamie I Baum, PhD
Have you considered Tri-Previfem clinical trials? We made a collection of clinical trials featuring Tri-Previfem, we think they might fit your search criteria.Go to Trials
Image of William J. Hybl Sports Medicine and Performance Center in Colorado Springs, United States.

Moderate Aerobic Exercise for Menstrual Symptoms

18 - 40
Female
Colorado Springs, CO
The goal of this clinical trial is to evaluate the impact of moderate aerobic exercise on menstrual symptom management in sedentary women both using and not using hormonal contraceptives. The main questions it aims to answer are: Is there a reduction in physical and/or psychological menstrual cycle related symptom burden with participation in moderate aerobic exercise for sedentary women using and not using hormonal contraceptives? Is there a difference in physical and/or psychological menstrual cycle related symptom burden between hormonal contraceptive and non-hormonal contraceptive users? Is a moderate aerobic exercise intervention more effective in reducing physical and/or psychological menstrual related symptom burden for sedentary women using or not using hormonal contraceptives? Participants will: * Have their body composition assessed using dual energy X-ray absorptiometry pre and post exercise intervention. * Complete a Menstrual Symptom Index (MSi) to report daily menstrual cycle related symptom burden in addition to the Premenstrual Symptom Screening Tool (PSST) and Heavy Menstrual Bleeding (HMB) questionnaire monthly. * Utilize an at-home monitor to test urinary luteinizing hormone, estrone-3-glucuronide, and pregnanediol glucuronide approximately 10 times per month and report menstrual cycle length. * Record physical activity habits by continuously wearing a wrist-based accelerometer and chest-strap heart rate monitor during planned aerobic exercise sessions and complete the International Physical Activity Questionnaire (IPAQ) monthly. * Maintain their usual sedentary activity habits for one menstrual cycle followed by completion of an exercise intervention designed to progress individuals to meet minimum recommended aerobic physical activity guidelines of 150 minutes per week set by the American College of Sports Medicine for two menstrual cycles.
Recruiting
Has No Placebo
William J. Hybl Sports Medicine and Performance Center
Image of School of Allied Health Professions in Loma Linda, United States.

Seed Cycling for Menstrual Disorder

18 - 45
Female
Loma Linda, CA
The purpose of this research is to investigate the impact of seed cycling on menstrual regularity, cramps, and pre-menstrual symptoms in women with an irregular menstrual cycle and/or dysmenorrhea. The research seeks to provide evidence-based insights into the potential benefits of seed cycling as a holistic approach to women's reproductive health. It is expected that your participation will last 3 months. Procedures and Activities. You will be provided with and asked to consume specific seeds daily. The seeds are to be consumed as follows: follicular phase (the period from the first day of menstruation (day 1) to ovulation (day 14) in a typical 28-day cycle): 1 tablespoon flax seeds and 1 tablespoon pumpkin seeds, and luteal phase (the period between ovulation and the start of the next period; typically days 15-28): 1 tablespoon sunflower seeds and 1 tablespoon sesame seeds. Before the intervention and once monthly for a total of 3 cycles, you will be asked to complete an online menstrual health symptom questionnaire (MHSQ) and keep track of your menstrual cycle days on the built-in health tracking app on your electronic device. Risks. Some of the foreseeable risks or discomforts of your participation include the potential for mild gastrointestinal side effects, the potential for allergic reactions, and the possibility of no significant benefit. Benefits. Possible benefits include the potential for improved menstrual cycle regularity, the potential for a reduction in premenstrual syndrome (PMS) symptoms, and the potential for nutritional benefits. Societal benefits include additional knowledge on seed cycling to help manage menstrual regularity and PMS symptoms.
Waitlist Available
Has No Placebo
School of Allied Health Professions
Have you considered Tri-Previfem clinical trials? We made a collection of clinical trials featuring Tri-Previfem, we think they might fit your search criteria.Go to Trials
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Estradiol and Elagolix for Menopause

42 - 64
Female
University Park, PA
The frequency and severity of heat waves has increased in the last decades. Older adults (over 65 years) have impaired responses to heat stress making them at increased risk for adverse events. Previous heat waves report that women over 65 experience worse health outcomes than any other age group and age matched men. Aging and reproductive hormones, specifically estrogen, independently alter responses to heat stress. However, the combined effects of low estrogen following menopause and aging on the response to heat stress are unknown. In this study, the investigators will identify the role of estrogen in pre and post menopausal women on thermoregulatory responses to heat stress.
Phase 4
Recruiting
Noll LaboratoryW. Larry Kenney, Ph.D.
Have you considered Tri-Previfem clinical trials? We made a collection of clinical trials featuring Tri-Previfem, we think they might fit your search criteria.Go to Trials
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