Vitamin K1

Jaundice, Obstructive, long-acting anticoagulant rodenticides, Vitamin K deficiency + 17 more

Treatment

7 FDA approvals

20 Active Studies for Vitamin K1

Treatment for

Jaundice, Obstructive

What is Vitamin K1

PhylloquinoneThe Generic name of this drug

Treatment SummaryVitamin K1, also known as phylloquinone or phytonadione, is a type of fat-soluble vitamin used since 1939. It helps the body form blood clotting factors and is used to treat coagulation disorders caused by a vitamin K deficiency. Vitamin K1 has been approved by the FDA since 1955.

Mephytonis the brand name

image of different drug pills on a surface

Vitamin K1 Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Mephyton

Phylloquinone

1955

65

Approved as Treatment by the FDA

Phylloquinone, also known as Mephyton, is approved by the FDA for 7 uses including hemorrhagic disease of the newborn and antibacterial therapy .

hemorrhagic disease of the newborn

antibacterial therapy

Hypoprothrombinemia

Hemorrhagic Disease of Newborn

Fistula, Biliary

Used to treat Fistula, Biliary in combination with Taurocholic acid

Salicylate

Jaundice, Obstructive

Used to treat Jaundice, Obstructive in combination with Taurocholic acid

Effectiveness

How Vitamin K1 Affects PatientsPhylloquinone is a type of vitamin K that can help treat blood clotting issues caused by a vitamin K deficiency. It stays in the body for a long time, so it only needs to be taken occasionally. Most people can tolerate large doses of this vitamin, but it's important to monitor prothrombin time while taking it and be aware of the risk of allergic reactions when given through a needle.

How Vitamin K1 works in the bodyVitamin K helps the body form blood clots. It does this by attaching carboxylic acid groups to a molecule called glutamate, which helps clotting factors bind to calcium. These clotting factors are released from the liver, restoring normal clotting. Vitamin K may also help protect joints from calcification, increase type two collagen and help with bone density. Researchers are still investigating its effects on arthritis, bone density and artery calcification.

When to interrupt dosage

The dose of Vitamin K1 is contingent upon the diagnosed condition, including Sprue, Vitamin supplementation and Ulcerative Colitis. The magnitude of dosage is subject to the application method itemized in the table below.

Condition

Dosage

Administration

Intestinal resection

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral

Hemorrhagic Disease of Newborn

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral

Crohn Disease

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral

Coagulation Disorder

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral

Sprue

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral

Jaundice, Obstructive

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral

long-acting anticoagulant rodenticides

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral

Vitamin K deficiency

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral

hemorrhagic disease of the newborn

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral

Hypoprothrombinemia

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral

Salicylate

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral

antibacterial therapy

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral

Vitamin supplementation

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral

Ulcerative Colitis

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral

Fistula, Biliary

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral

Gluten-Sensitive Enteropathy

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral

Anticoagulant Therapy

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral

Vitamin supplementation therapy

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral

vitamin K

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral

Pancreatic Cystic Fibrosis

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Oral, Tablet, Tablet - Oral, Parenteral, Injection, emulsion, Injection, emulsion - Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Emulsion - Intramuscular; Intravenous; Subcutaneous, Intramuscular, Liquid - Intramuscular, Liquid, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid - Intravenous, Kit, Kit - Oral, Injection, Injection - Intravenous, Solution / drops, Solution / drops - Oral

Warnings

Vitamin K1 Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Phylloquinone may interact with Pulse Frequency

There are 20 known major drug interactions with Vitamin K1.

Common Vitamin K1 Drug Interactions

Drug Name

Risk Level

Description

(R)-warfarin

Major

The therapeutic efficacy of (R)-warfarin can be decreased when used in combination with Phylloquinone.

(S)-Warfarin

Major

The therapeutic efficacy of (S)-Warfarin can be decreased when used in combination with Phylloquinone.

4-hydroxycoumarin

Major

The therapeutic efficacy of 4-hydroxycoumarin can be decreased when used in combination with Phylloquinone.

Acenocoumarol

Major

The therapeutic efficacy of Acenocoumarol can be decreased when used in combination with Phylloquinone.

Clorindione

Major

The therapeutic efficacy of Clorindione can be decreased when used in combination with Phylloquinone.

Vitamin K1 Toxicity & Overdose RiskTaking too much vitamin K1 can be dangerous, especially when given through an IV. The toxic dose of vitamin K1 for mice is 1170 mg/kg when given intravenously and more than 24180 mg/kg when given orally. If someone overdoses on vitamin K1, they should be treated with supportive care.

image of a doctor in a lab doing drug, clinical research

Vitamin K1 Novel Uses: Which Conditions Have a Clinical Trial Featuring Vitamin K1?

At present, 100 active studies are in progress to evaluate the potential of Vitamin K1 in addressing Crohn Disease, Hemorrhagic Disease of the Newborn and Obstructive Jaundice.

Condition

Clinical Trials

Trial Phases

Ulcerative Colitis

99 Actively Recruiting

Phase 2, Not Applicable, Phase 3, Phase 1, Phase 4, Early Phase 1

long-acting anticoagulant rodenticides

0 Actively Recruiting

Sprue

0 Actively Recruiting

Hypoprothrombinemia

0 Actively Recruiting

hemorrhagic disease of the newborn

0 Actively Recruiting

Vitamin supplementation

0 Actively Recruiting

Crohn Disease

0 Actively Recruiting

Vitamin K deficiency

0 Actively Recruiting

Salicylate

0 Actively Recruiting

Intestinal resection

0 Actively Recruiting

Fistula, Biliary

0 Actively Recruiting

vitamin K

0 Actively Recruiting

Vitamin supplementation therapy

0 Actively Recruiting

Jaundice, Obstructive

0 Actively Recruiting

Pancreatic Cystic Fibrosis

0 Actively Recruiting

Coagulation Disorder

4 Actively Recruiting

Phase 3, Not Applicable, Phase 1

Gluten-Sensitive Enteropathy

0 Actively Recruiting

Hemorrhagic Disease of Newborn

0 Actively Recruiting

Anticoagulant Therapy

0 Actively Recruiting

antibacterial therapy

0 Actively Recruiting

Patient Q&A Section about vitamin k1

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Which is better to take vitamin K1 or K2?

"Several studies have suggested that vitamin K2 is better than K1 at reducing calcium deposits and lowering your risk of heart disease."

Answered by AI

Is vitamin K1 the same as vitamin K?

"Vitamin K1 is the main form of vitamin K in the diet. It's found in green vegetables and in plant chlorophylls. Vitamin K2 is made by bacteria and is found in food where bacteria are part of the production process."

Answered by AI

What is vitamin K1 and K2 good for?

"There are two types of vitamin K, K1 and K2. Both are important for blood clotting and preventing excessive bruising and bleeding. However, recent research suggests that K2 may offer additional health benefits beyond those of K1."

Answered by AI

What is vitamin K1 used for?

"Vitamin K is essential for blood clotting, bone building, and other important processes. There are two main types of vitamin K: K1 (phytonadione) and K2 (menaquinone). Vitamin K1 is found in green vegetables, while vitamin K2 is commonly available as a supplement."

Answered by AI

Clinical Trials for Vitamin K1

Image of Mayo Clinic in Rochester, United States.

Patients with Pouchitis for Ulcerative Colitis

This trial investigates the use of intestinal ultrasound (IUS) in evaluating inflammatory bowel disease (IBD), specifically ulcerative colitis (UC) patients with an ileal pouch-anal anastom

Waitlist Available

Mayo ClinicDarrell Pardi, MD

Image of Center for Cancer and Blood Disorders in Bethesda, United States.

HMPL-523 for Hemorrhagic Disorders

"This trial will test the safety, side effects, and effectiveness of HMPL-523 in adults with ITP at multiple locations with full transparency about the treatment being administered."

Waitlist Available

Center for Cancer and Blood Disorders (+2 Sites)William Schelman, MD, PhDHutchmed

Image of VVCRD Research in Garden Grove, United States.

GS-1427 +1 More for Ulcerative Colitis

Garden Grove, CA

"This trial is testing a new drug, GS-1427, to see if it is safe and effective in treating people with moderate to severe ulcerative colitis. The study will compare different groups of

VVCRD Research (+5 Sites)Gilead Study DirectorGilead Sciences

Image of Ferring Investigational Site in North Little Rock, United States.

FE 999322 +1 More for Ulcerative Colitis

North Little Rock, AR

"This trial aims to test the safety of two different microbiota treatments compared to a placebo in people with mild to moderate ulcerative colitis."

No Cost For Treatment

Ferring Investigational Site (+2 Sites)Global Clinical ComplianceFerring Pharmaceuticals

Have you considered Vitamin K1 clinical trials? We made a collection of clinical trials featuring Vitamin K1, we think they might fit your search criteria.

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Image of Tyler Research Institute, LLC in Tyler, United States.

Vixarelimab for Ulcerative Colitis

This trial aims to study the effectiveness, safety, and how the body processes vixarelimab compared to a placebo in people with moderate to severe ulcerative colitis who have not responded well to

Tyler Research Institute, LLC (+1 Sites)Clinical TrialGenentech, Inc.

Image of AnaptysBio Investigative Site 10-101 in Kissimmee, United States.

Rosnilimab for Ulcerative Colitis

This trial will study a new drug to see if it can help people with UC, looking at safety, effectiveness, and how well it is tolerated.

AnaptysBio Investigative Site 10-101 (+4 Sites)Zurab Machaidze, MDAnaptysBio, Inc.

Image of Lucile Packard Children's Hospital and Clinics in Palo Alto, United States.

Medical Food (SPHi) for Ulcerative Colitis

This trial examines how well a new medical food can lower inflammation in children with ulcerative colitis by measuring an inflammatory biomarker.

Waitlist Available

Lucile Packard Children's Hospital and Clinics

Image of Gastro Associates of Florida / GI Alliance in Wellington, United States.

ALTB-268 for Ulcerative Colitis

This trial will assess a new drug, ALTB-268, for safety and effectiveness in treating moderate to severe ulcerative colitis. Subjects will receive weekly doses for 12 weeks, followed by bi-weekly doses for 40 weeks.

Gastro Associates of Florida / GI Alliance (+10 Sites)Jesse Hall, MDAltruBio Inc.

Have you considered Vitamin K1 clinical trials? We made a collection of clinical trials featuring Vitamin K1, we think they might fit your search criteria.

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Image of University of Michigan in Ann Arbor, United States.

Morning Light Treatment for Inflammatory Bowel Disease

This trial tests if changes to sleep and light can improve IBD symptoms.

University of MichiganCathy Goldstein, M.D., M.S.

Image of Clinical Research Institute of Michigan, LLC ( Site 0108) in Chesterfield, United States.

MK-7240 for Ulcerative Colitis

Chesterfield, MI

This trial will evaluate if MK-7240 is safe and effective for treating ulcerative colitis, with primary hypotheses evaluated at 12 and 52 weeks.

Clinical Research Institute of Michigan, LLC ( Site 0108) (+21 Sites)Medical DirectorMerck Sharp & Dohme LLC

Image of QEII Health Sciences Centre in Halifax, Canada.

Biologic Care Pathway for Crohn's Disease

Halifax, Canada

This trial aims to study the use of standardized care pathways for patients with Inflammatory Bowel Disease (IBD) to improve treatment outcomes. The researchers will investigate how implementing a Biologic Care Pathway

QEII Health Sciences Centre

Image of Physician's Clinical Research, Inc. (PCRI) in Toronto, Canada.

Tilpisertib for Ulcerative Colitis

Toronto, Canada

This trial will study the effectiveness and safety of a potential medication for ulcerative colitis. Participants will be randomly given the drug or a placebo.

Physician's Clinical Research, Inc. (PCRI) (+29 Sites)Gilead Study DirectorGilead Sciences

Have you considered Vitamin K1 clinical trials? We made a collection of clinical trials featuring Vitamin K1, we think they might fit your search criteria.

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