Amoxicillin And Clarithromycin

Zollinger-Ellison Syndrome, Curling Ulcer, maintenance of healing Erosive esophagitis + 9 more

Treatment

5 FDA approvals

5 Active Studies for Amoxicillin And Clarithromycin

What is Amoxicillin And Clarithromycin

Lansoprazole

The Generic name of this drug

Treatment Summary

Clarithromycin is an antibiotic used to treat bacterial infections. It works by preventing the bacteria from making proteins, which stops them from growing and multiplying. Depending on the type of bacteria and the concentration of the drug, clarithromycin can either stop the growth of the bacteria (bacteriostatic) or kill it (bactericidal).

Prevacid

is the brand name

image of different drug pills on a surface

Amoxicillin And Clarithromycin Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Prevacid

Lansoprazole

1995

326

Approved as Treatment by the FDA

Lansoprazole, otherwise known as Prevacid, is approved by the FDA for 5 uses like Duodenal Ulcer and Zollinger-Ellison Syndrome .

Duodenal Ulcer

Used to treat Duodenal Ulcer in combination with Amoxicillin

Zollinger-Ellison Syndrome

Helps manage Zollinger-Ellison Syndrome

hypersecretory conditions

Helps manage hypersecretory conditions

Helicobacter Pylori Infection

Used to treat Helicobacter Pylori Infection in combination with Amoxicillin

Curling Ulcer

Used to treat Duodenal Ulcer in combination with Amoxicillin

Effectiveness

How Amoxicillin And Clarithromycin Affects Patients

Clarithromycin is an antibiotic that is effective against a wide range of bacteria. This includes many common types of bacteria, such as Staphylococcus, Haemophilus, Moraxella, and Mycoplasma. It also works against certain viruses like Chlamydia, Toxoplasma, and Borrelia. Its strength is similar or greater than that of erythromycin, and it is usually effective at stopping the growth of bacteria without killing it, but it can kill some depending on the type and concentration.

How Amoxicillin And Clarithromycin works in the body

Clarithromycin works in two ways to fight infection. First, it penetrates the bacterial cell wall, then binds to the ribosome. This prevents the bacteria from making proteins and reproducing. Clarithromycin also inhibits two enzymes which work to break down certain drugs in the body, making them more effective.

When to interrupt dosage

The endorsed dosage of Amoxicillin And Clarithromycin is contingent upon the diagnosed condition, including Mycobacterium Infections, Lyme Disease and Bacterial Infections. The measure of dosage fluctuates as per the technique of delivery (e.g. Powder, for suspension or Capsule; Kit; Tablet) featured in the table beneath.

Condition

Dosage

Administration

Zollinger-Ellison Syndrome

, 15.0 mg, 30.0 mg, 30.0 mg/mL

Kit, , Oral, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Capsule, delayed release pellets, Tablet, delayed release - Oral, Tablet, delayed release, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Suspension, Suspension - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Capsule - Oral, Kit - Oral, Capsule, delayed release pellets - Oral, Injection, Injection - Intravenous, Capsule

Curling Ulcer

, 15.0 mg, 30.0 mg, 30.0 mg/mL

Kit, , Oral, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Capsule, delayed release pellets, Tablet, delayed release - Oral, Tablet, delayed release, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Suspension, Suspension - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Capsule - Oral, Kit - Oral, Capsule, delayed release pellets - Oral, Injection, Injection - Intravenous, Capsule

maintenance of healing Erosive esophagitis

, 15.0 mg, 30.0 mg, 30.0 mg/mL

Kit, , Oral, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Capsule, delayed release pellets, Tablet, delayed release - Oral, Tablet, delayed release, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Suspension, Suspension - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Capsule - Oral, Kit - Oral, Capsule, delayed release pellets - Oral, Injection, Injection - Intravenous, Capsule

Duodenal Ulcer

, 15.0 mg, 30.0 mg, 30.0 mg/mL

Kit, , Oral, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Capsule, delayed release pellets, Tablet, delayed release - Oral, Tablet, delayed release, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Suspension, Suspension - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Capsule - Oral, Kit - Oral, Capsule, delayed release pellets - Oral, Injection, Injection - Intravenous, Capsule

NSAID use

, 15.0 mg, 30.0 mg, 30.0 mg/mL

Kit, , Oral, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Capsule, delayed release pellets, Tablet, delayed release - Oral, Tablet, delayed release, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Suspension, Suspension - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Capsule - Oral, Kit - Oral, Capsule, delayed release pellets - Oral, Injection, Injection - Intravenous, Capsule

hypersecretory conditions

, 15.0 mg, 30.0 mg, 30.0 mg/mL

Kit, , Oral, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Capsule, delayed release pellets, Tablet, delayed release - Oral, Tablet, delayed release, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Suspension, Suspension - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Capsule - Oral, Kit - Oral, Capsule, delayed release pellets - Oral, Injection, Injection - Intravenous, Capsule

Helicobacter Pylori Infection

, 15.0 mg, 30.0 mg, 30.0 mg/mL

Kit, , Oral, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Capsule, delayed release pellets, Tablet, delayed release - Oral, Tablet, delayed release, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Suspension, Suspension - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Capsule - Oral, Kit - Oral, Capsule, delayed release pellets - Oral, Injection, Injection - Intravenous, Capsule

Erosive Esophagitis

, 15.0 mg, 30.0 mg, 30.0 mg/mL

Kit, , Oral, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Capsule, delayed release pellets, Tablet, delayed release - Oral, Tablet, delayed release, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Suspension, Suspension - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Capsule - Oral, Kit - Oral, Capsule, delayed release pellets - Oral, Injection, Injection - Intravenous, Capsule

Ulcer Healing

, 15.0 mg, 30.0 mg, 30.0 mg/mL

Kit, , Oral, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Capsule, delayed release pellets, Tablet, delayed release - Oral, Tablet, delayed release, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Suspension, Suspension - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Capsule - Oral, Kit - Oral, Capsule, delayed release pellets - Oral, Injection, Injection - Intravenous, Capsule

A History of Gastric or Duodenal Ulcers

, 15.0 mg, 30.0 mg, 30.0 mg/mL

Kit, , Oral, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Capsule, delayed release pellets, Tablet, delayed release - Oral, Tablet, delayed release, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Suspension, Suspension - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Capsule - Oral, Kit - Oral, Capsule, delayed release pellets - Oral, Injection, Injection - Intravenous, Capsule

Stomach Ulcer

, 15.0 mg, 30.0 mg, 30.0 mg/mL

Kit, , Oral, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Capsule, delayed release pellets, Tablet, delayed release - Oral, Tablet, delayed release, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Suspension, Suspension - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Capsule - Oral, Kit - Oral, Capsule, delayed release pellets - Oral, Injection, Injection - Intravenous, Capsule

Gastroesophageal reflux disease

, 15.0 mg, 30.0 mg, 30.0 mg/mL

Kit, , Oral, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Capsule, delayed release pellets, Tablet, delayed release - Oral, Tablet, delayed release, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Suspension, Suspension - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Capsule - Oral, Kit - Oral, Capsule, delayed release pellets - Oral, Injection, Injection - Intravenous, Capsule

Warnings

Amoxicillin And Clarithromycin has eight contraindications, so it should not be taken with any of the conditions stated in the following table.

There are 20 known major drug interactions with Amoxicillin And Clarithromycin.

Common Amoxicillin And Clarithromycin Drug Interactions

Drug Name

Risk Level

Description

Albendazole

Major

The metabolism of Albendazole can be decreased when combined with Lansoprazole.

Amoxapine

Major

The metabolism of Amoxapine can be decreased when combined with Lansoprazole.

Apixaban

Major

The metabolism of Apixaban can be decreased when combined with Lansoprazole.

Artemether

Major

The metabolism of Artemether can be decreased when combined with Lansoprazole.

Astemizole

Major

The metabolism of Astemizole can be decreased when combined with Lansoprazole.

Amoxicillin And Clarithromycin Toxicity & Overdose Risk

Signs of clarithromycin toxicity can include diarrhea, nausea, changes in taste, stomach upset, and abdominal pain. Rarely, hearing loss, severe allergic reactions, hepatitis, and tooth discoloration may occur. Animal studies suggest that the drug may cause birth defects such as heart and facial deformities, as well as slowed fetal growth. Clarithromycin can also increase the heart rate and cause an irregular heartbeat.

image of a doctor in a lab doing drug, clinical research

Amoxicillin And Clarithromycin Novel Uses: Which Conditions Have a Clinical Trial Featuring Amoxicillin And Clarithromycin?

160 active clinical trials are currently investigating the potential of the combination of Amoxicillin and Clarithromycin in mitigating Pertussis, HIV and Urinary Tract Infections (UTIs).

Condition

Clinical Trials

Trial Phases

hypersecretory conditions

0 Actively Recruiting

A History of Gastric or Duodenal Ulcers

0 Actively Recruiting

Duodenal Ulcer

0 Actively Recruiting

maintenance of healing Erosive esophagitis

0 Actively Recruiting

Curling Ulcer

0 Actively Recruiting

NSAID use

0 Actively Recruiting

Ulcer Healing

1 Actively Recruiting

Not Applicable

Stomach Ulcer

0 Actively Recruiting

Helicobacter Pylori Infection

2 Actively Recruiting

Not Applicable, Phase 4

Zollinger-Ellison Syndrome

0 Actively Recruiting

Gastroesophageal reflux disease

0 Actively Recruiting

Erosive Esophagitis

2 Actively Recruiting

Phase 2, Phase 3

Patient Q&A Section about amoxicillin and clarithromycin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Which is better amoxicillin or clarithromycin?

"Thisstudy found that clarithromycin may be just as effective as amoxicillin/clavulanate for treating acute maxillary sinusitis, and it may cause fewer gastrointestinal problems."

Answered by AI

Can you take amoxicillin and clarithromycin at the same time?

"Amoxicillin, clarithromycin, and omeprazole are antibiotics that fight bacteria. Helicobacter pylori is a common infection that can cause stomach ulcers. Amoxicillin, clarithromycin, and omeprazole are effective at treating this infection and preventing stomach ulcers."

Answered by AI

What are the side effects of clarithromycin and amoxicillin?

"You may have diarrhea, stomach pain or cramps, vomiting, nausea, a change in ability to taste food, a headache, or dizziness."

Answered by AI

Can you take amoxicillin and clindamycin together?

"There are no known negative interactions between amoxicillin and Cleocin HCL."

Answered by AI

Clinical Trials for Amoxicillin And Clarithromycin

Image of Brigham and Women's Hospital in Boston, United States.

Argon Plasma for Helicobacter Pylori Infection

18+
All Sexes
Boston, MA

The objective of the study is to investigate the efficacy and safety of an argon plasma-based therapy - HEAPE - in treating H. pylori infections during endoscopic procedures. By filling the stomach with sodium chloride solution that is treated with APC (PAL), the Investigators hypothesize a significant reduction in H. pylori. The use of PAL instead of direct application of APC allows for a broader and more homogeneous application throughout the stomach and a faster procedure time, as the fluid bypasses the thermal effects typically associated with higher electrical power settings and focuses on the bactericidal action of PAL. It is a procedure that does not involve thermal ablation of the stomach lining. Thus, side effects should be expected to be as low as possible. Two different PAL generation modalities will be compared in this study: 1. HEAPE direct: This modality is the direct generation of PAL in the stomach. The stomach is filled with sodium chloride solution which is then treated with APC. With HEAPE direct a potential decrease of reactive species is avoided, as the treatment happens directly at the intended location in the H. pylori infected stomach. 2. Pre-HEAPE: This modality features the treatment of sodium chloride with APC outside of the patient in a sterile container. After the APC treatment, the generated PAL is administered into the stomach with a syringe through the working channel of the endoscope. Pre-HEAPE allows an easier handling of the APC probe as the treatment of the sodium chloride solution can be done without an endoscope. To evaluate the immediate effect of this novel treatment approach the metabolic activity of H. pylori will be assessed using a urea breath test (UBT) before and after treatment. A reduction in H. pylori levels can be detected by a reduction in urease activity in the breath test. After the HEAPE procedure, patients are treated with antibiotics (best practice) as they would be under normal circumstances. Four weeks after treatment, another UBT is performed to determine if H. pylori has been eradicated or if additional antibiotic treatment is indicated. This two-arm, randomized, pilot, single-center, prospective clinical study is designed to evaluate the safety, tolerability and proof of concept that PAL has the ability to eradicate or reduce the bacterial load of H. pylori in humans.

Recruiting
Has No Placebo

Brigham and Women's Hospital

Christopher C Thompson, MD

Erbe Elektromedizin GmbH

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