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Neuromodulation for Depression and Memory Loss in Older Adults
N/A
Recruiting
Research Sponsored by Hebrew SeniorLife
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change from baseline demqol at 3 month follow-up
Awards & highlights
Study Summary
This trial seeks to explore if brain stimulation therapy can help relieve mood & memory symptoms in older adults with depression & dementia.
Who is the study for?
This trial is for older adults with major depressive disorder and dementia who can follow the study's rules, communicate in English, and have a caregiver over 21 years old to help. Participants must be able to see well enough and not have severe arthritis or skin conditions on the scalp that could interfere with treatment.Check my eligibility
What is being tested?
The trial tests home-based brain stimulation therapies—transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS)—to improve mood and memory symptoms in older adults suffering from depression within the context of dementia.See study design
What are the potential side effects?
Potential side effects may include discomfort at the site of electrode placement, itching, tingling during the session, fatigue, headache, nausea or insomnia. These are usually mild and temporary.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ change from baseline csdd total score at 3 months follow-up
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change from baseline csdd total score at 3 months follow-up
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Secondary outcome measures
Altman Self-Rating Mania Scale (ASRM)
Category and Phonemic Fluency Test
Cornell Scale for Depression in Dementia (CSDD)
+8 moreTrial Design
1Treatment groups
Experimental Treatment
Group I: tDCS prefrontal cortex + tASC angular gyrus in MDD in the context of ADExperimental Treatment1 Intervention
Participants will undergo 20 sessions of home-based tDCS over the prefrontal cortex and tACS over the left angular gyrus.These sessions will take place five times a week for four weeks, with one daily stimulation session of no more than 20 minutes. The participant's home will be the setting for the completion of the brain stimulation intervention, which will be delivered by trained caregivers/study companions/administrators.
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Who is running the clinical trial?
Brain & Behavior Research FoundationOTHER
61 Previous Clinical Trials
2,793 Total Patients Enrolled
Hebrew SeniorLifeLead Sponsor
45 Previous Clinical Trials
270,529 Total Patients Enrolled
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Eligibility Criteria:
This trial includes the following eligibility criteria:- My caregiver is at least 21 years old.I don't have conditions or take medications that would make tES unsafe for me.My caregiver is available on weekdays to help with my treatment.You scored 18 or lower on the Montreal Cognitive Assessment (MoCA) during the in-person screening.You have slight problems with memory and thinking, as measured by a test called MoCA with a score of 26 or lower during a face-to-face evaluation.I have a condition like poor eyesight or severe arthritis that makes it hard for me to manage treatments on my own.I understand the study details and agree to participate.I am unable to perform tasks due to blindness or other disabilities.I have an active skin condition like eczema on my scalp.
Research Study Groups:
This trial has the following groups:- Group 1: tDCS prefrontal cortex + tASC angular gyrus in MDD in the context of AD
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What is the scope of participants in this clinical research?
"Affirmative. According to clinicaltrials.gov, this research trial is presently enrolling participants. It was first posted on January 24th 2023 and the most recent update occurred on July 27th 2023. Presently, they are recruiting for a total of 20 individuals at one site location."
Answered by AI
Is enrollment still open for those seeking to participate in this trial?
"Affirmative. The information posted on clinicaltrials.gov suggests that this trial is currently recruiting participants. It was initially published on January 24th 2023 and the details were most recently updated July 27th 2023, with a target of enrolling 20 patients at one location."
Answered by AI
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