RLN and CCN for Reading Disability

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Vanderbilt University Medical Center, Nashville, TN
Reading Disability+1 More
CCN real non-invasive brain stimulation intervention - Device
Eligibility
18 - 65
All Sexes
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Study Summary

The goal of this project is to address the urgent need for effective, scalable adult literacy interventions by integrating breakthroughs in two separate fields: 1.) the brain network science of resilience to reading disorders and 2.) high-definition non-invasive brain network stimulation. This study will first establish the efficacy of a novel, noninvasive stimulation protocol on reading behavior and brain metrics; then will determine how stimulation-induced effects interact with baseline reading comprehension ability; and lastly, will identify whether stimulation-induced effects are more clinically-beneficial than canonical behavioral interventions. Results may foundationally change how we treat low adult literacy, and have the potential for wider reaching impacts on non-invasive stimulation protocols for other clinical disorders.

Eligible Conditions

  • Reading Disability

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

2 Primary · 1 Secondary · Reporting Duration: Baseline to 12 month

Baseline to 12 month
Change in brain activations during reading
Baseline to 12 months
Change in reading comprehension ability on standardized test measure
Performance in reading comprehension ability on test measure during stimulation session

Trial Safety

Trial Design

4 Treatment Groups

RLN and CCN
1 of 4
Cognitive Control Network (CCN)
1 of 4
Reading and Language Network (RLN)
1 of 4
Sham stimulation
1 of 4
Experimental Treatment
Non-Treatment Group

225 Total Participants · 4 Treatment Groups

Primary Treatment: RLN and CCN · Has Placebo Group · N/A

RLN and CCN
Device
Experimental Group · 1 Intervention: RLN and CCN real non-invasive brain stimulation intervention · Intervention Types: Device
Cognitive Control Network (CCN)
Device
Experimental Group · 1 Intervention: CCN real non-invasive brain stimulation intervention · Intervention Types: Device
Reading and Language Network (RLN)
Device
Experimental Group · 1 Intervention: RLN real non-invasive brain stimulation intervention · Intervention Types: Device
Sham stimulation
Device
ShamComparator Group · 1 Intervention: Sham intervention · Intervention Types: Device

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline to 12 month

Trial Background

Prof. Katherine Aboud, Research Assistant Professor
Principal Investigator
Vanderbilt University
Closest Location: Vanderbilt University Medical Center · Nashville, TN
Photo of vanderbilt university medical center  1Photo of vanderbilt university medical center  2Photo of vanderbilt university medical center  3
2006First Recorded Clinical Trial
1 TrialsResearching Reading Disability
1019 CompletedClinical Trials

Eligibility Criteria

Age 18 - 65 · All Participants · 1 Total Inclusion Criteria

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About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.