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Procedure

Radiofrequency Ablation for Thyroid Cancer

N/A
Waitlist Available
Led By Jonathon Russell, MD
Research Sponsored by Johns Hopkins University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Patients between the ages 18-100 with biopsy proven PTMC with a Bethesda V or VI pathology or indeterminate cytology on fine-needle aspiration cytology (FNAC) who are recommended for treatment (Bethesda III/IV)
At least 1 mm of normal tissue as a margin, without sonographic evidence of contact with the capsule
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 24 months
Awards & highlights

Study Summary

This trial is comparing the safety, efficacy and oncological outcomes of radiofrequency ablation (RFA) of low risk papillary thyroid microcarcinoma (PTMC) to active surveillance (AS) in patients at Johns Hopkins Medical Institute.

Who is the study for?
This trial is for adults aged 18-100 with a specific small thyroid cancer (PTMC) that hasn't spread and is less than 20mm. It's not for pregnant individuals, those with other types of thyroid cancer, certain genetic mutations, larger tumors, previous RFA treatment, multiple cancers in the thyroid, nerve issues affecting the voice box or evidence of cancer spread.Check my eligibility
What is being tested?
The study tests Radiofrequency Ablation (RFA), a less invasive alternative to surgery for treating low-risk papillary thyroid microcarcinoma. The goal is to see if it's safe and effective compared to just watching the tumor without intervention at Johns Hopkins Medical Institute.See study design
What are the potential side effects?
While not explicitly listed in this summary, potential side effects of RFA may include pain at the site of ablation, swelling or bruising around the neck area where treatment occurs and temporary voice changes due to nerve irritation.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am 18-100 years old with a specific thyroid cancer diagnosis recommended for treatment.
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My surgery removed the tumor with a small clear margin and no signs of touching the outer layer.
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My thyroid cancer has not spread beyond my thyroid.
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I have a single thyroid nodule smaller than 20mm.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~24 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 24 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Secondary outcome measures
Change in eating assessment score as assessed by the EAT-10
Change in overall quality of life assessed by the PROMIS score
Change in voice related quality of life as assessed by the VHI-10
+3 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: Radiofrequency AblationExperimental Treatment1 Intervention
Patients will receive RFA as a one-time intervention, with a possible second treatment after 6 months if adequate resolution is not noted on ultrasound.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Radiofrequency Ablation
2013
Completed Phase 4
~740

Find a Location

Who is running the clinical trial?

Johns Hopkins UniversityLead Sponsor
2,256 Previous Clinical Trials
14,820,061 Total Patients Enrolled
Jonathon Russell, MDPrincipal InvestigatorJohns Hopkins University

Media Library

Radiofrequency Ablation (Procedure) Clinical Trial Eligibility Overview. Trial Name: NCT05132205 — N/A
Thyroid Cancer Research Study Groups: Radiofrequency Ablation
Thyroid Cancer Clinical Trial 2023: Radiofrequency Ablation Highlights & Side Effects. Trial Name: NCT05132205 — N/A
Radiofrequency Ablation (Procedure) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05132205 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is enrollment for this research program open at the present time?

"Information available on clinicaltrials.gov suggests this trial is no longer enrolling patients; the post was initially published on December 17th, 2021 and last updated on December 5th 2022. Nevertheless, there are still 228 other medical studies actively recruiting right now."

Answered by AI

Is it possible to participate in this medical trial?

"To qualify for the trial, applicants must have a thyroid adenoma and fall between the ages of 18 and 100. Currently, this clinical study is looking to enroll 10 patients in total."

Answered by AI

Does this research include participants who are older than two decades?

"The requirements for participation in this trial dictate that patients must lie within the parameters of 18 to 100 years old. For younger persons, there are 30 available studies and 218 for those aged over 65."

Answered by AI

Who else is applying?

What site did they apply to?
Johns Hopkins Hospital
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
0

Why did patients apply to this trial?

From my research, I have come to strongly believe in Ablation Therapy.
PatientReceived 2+ prior treatments
Recent research and studies
clinicaltrials.govStudy
Radiofrequency Ablation of Papillary Thyroid Microcarcinoma
2021. "Radiofrequency Ablation of Papillary Thyroid Microcarcinoma". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05132205.
All > Thyroid
~2 spots leftby Sep 2024
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