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Behavioural Intervention
Gamma tACS for Memory and Sleep Improvement
N/A
Waitlist Available
Led By Flavio Frohlich, PhD
Research Sponsored by University of North Carolina, Chapel Hill
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
>50 years old
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline (day 1), follow-up (day 2)
Awards & highlights
Study Summary
This trial tests a non-invasive brain stimulation to improve memory recall and sleep in healthy elderly people. It involves lab visits and EEG collection at home.
Who is the study for?
This trial is for healthy elderly individuals over 50 years old who are interested in participating in a study to improve memory and sleep. Participants will undergo non-invasive brain stimulation and cognitive testing, with follow-up sessions to measure the effects.Check my eligibility
What is being tested?
The trial tests if gamma transcranial alternating current stimulation (tACS) can boost memory recall and affect sleep patterns in older adults. It compares gamma frequency tACS against a control frequency, using EEG headbands at home and actigraphy wristbands to monitor results.See study design
What are the potential side effects?
Transcranial alternating current stimulation may cause mild side effects such as tingling on the scalp, dizziness, or headaches during or after treatment. The intensity of these side effects varies from person to person.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ baseline (day 1), follow-up (day 2)
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline (day 1), follow-up (day 2)
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Amount of Sleep Spindles in Sleep-EEG
Amount of Slow Wave Sleep in Sleep-EEG
Associative Verbal Memory at Day 1
+8 moreSecondary outcome measures
Attentional Performance (TAP)
Executive Functioning (Stroop Test)
Executive Functioning (Trail Making Test)
+1 moreOther outcome measures
Exploration of a Relationship (Correlation) between the Amount of Sleep Spindles and Slow Wave Sleep with Recall
Exploration of a Relationship (Correlation) of Sleep-Wake-Schedule changes and Type of Stimulation
Trial Design
2Treatment groups
Experimental Treatment
Group I: First gamma (40Hz) stimulation, then active control (21Hz) stimulationExperimental Treatment4 Interventions
After collecting sleep EEG at home for one night to acclimate to the data collection during sleep, participants first receive gamma (40Hz) tACS on Day 1 followed by a 5-9 day washout. Participants then receive active control (21Hz) stimulation.
Group II: First active control (21 Hz) stimulation, then gamma (40 Hz) stimulationExperimental Treatment4 Interventions
After collecting sleep EEG at home for one night to acclimate to the data collection during sleep, participants first receive active control (21Hz) tACS on Day 1 followed by a 5-9 day washout. Participants then receive gamma (40Hz) stimulation.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Gamma transcranial alternating current stimulation
2023
N/A
~10
Control transcranial alternating current stimulation
2023
N/A
~10
EEG headband
2023
N/A
~10
Actigraphy wristband
2023
N/A
~10
Find a Location
Who is running the clinical trial?
University of North Carolina, Chapel HillLead Sponsor
1,504 Previous Clinical Trials
4,187,652 Total Patients Enrolled
Flavio Frohlich, PhDPrincipal InvestigatorUniversity of North Carolina, Chapel Hill
19 Previous Clinical Trials
709 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:Research Study Groups:
This trial has the following groups:- Group 1: First active control (21 Hz) stimulation, then gamma (40 Hz) stimulation
- Group 2: First gamma (40Hz) stimulation, then active control (21Hz) stimulation
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What objectives are this investigation attempting to achieve?
"The main objective of this trial is to ascertain the rate at which participants can successfully complete cognitive testing during transcranial alternating current stimulation (tACS). Secondary goals include assessing executive functioning with a Stroop Test and Trail Making Test, as well as measuring attentional performance via the Test of Attentional Performance (TAP). All assessments will be conducted both immediately following tACS as well as in the days that follow."
Answered by AI
Are there any available slots for participation in this experiment?
"According to the clinicaltrials.gov information provided, this study is not accepting new patients at this time. The trial was first published on June 12th 2023 and has since been edited; however, 975 other trials are actively recruiting participants now."
Answered by AI
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