Transcranial alternating current stimulation (tACS) for Memory Loss

Recruiting · 18+ · All Sexes · Boston, MA

This study is evaluating whether a remote device can help improve memory for older adults.

See full description

About the trial for Memory Loss

Eligible Conditions
Alzheimer Disease · Memory Disorders · Memory Losses

Treatment Groups

This trial involves 2 different treatments. Transcranial Alternating Current Stimulation (tACS) is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
Transcranial alternating current stimulation (tACS)
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.


This trial is for patients born any sex aged 18 and older. There are 10 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
They were able to identify an eligible administrator to participate with them in the study. show original
The study found that participants who reported being comfortable using a computer and being willing to learn how to use tACS were more likely to have a positive experience using tACS. show original
You must be at least 21 years old to purchase this product. show original
The study period availability of tACS was stated to be during weekday only. show original
Participants (Ps)
willing and capable to give informed consent for the participation in the study after it has been thoroughly explained
able and willing to comply with all study requirements
I agreed to the proposed plan after reading and understanding the informed consent form. show original
Can read, write, and communicate in English. show original
Administrators (As)
View All
Odds of Eligibility
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial

Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: 48 weeks
Screening: ~3 weeks
Treatment: Varies
Reporting: 48 weeks
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: 48 weeks.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Transcranial alternating current stimulation (tACS) will improve 2 primary outcomes in patients with Memory Loss. Measurement will happen over the course of 48 weeks.

Electroencephalography (EEG) measures
High-density EEG (257 channels) will be recorded before and after the tACS intervention and changes in spatiotemporal dynamics in different frequency bands (theta, alpha, beta, gamma) will be assessed
Clinical Evaluation and Cognitive Assessment
a trained clinician will administer the Montreal Cognitive Assessment (MOCA) to characterize cognitive status and the level of dementia

Who is running the study

Principal Investigator
A. P.
Alvaro Pascual-Leone, Senior Scientist
Hebrew SeniorLife

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can memory loss be cured?

Memory loss is an irreversible process of the brain. There is no cure for the symptoms of Alzheimer's disease. However, with adequate support and treatment the memory loss can often be reduced.

Anonymous Patient Answer

What is memory loss?

This is the first study to demonstrate that loss of memory occurs in both children and aged adults during childhood and adolescence. The data demonstrated that childhood and adolescence are critical periods and that memory loss may be irreversible.

Anonymous Patient Answer

What causes memory loss?

The brain has the ability to perform specialized functions that include consolidation of memories. It also has the ability to recover from damage or damage of part of the brain. In humans, memory loss can affect learning tasks, reading, and the ability to communicate with others. The most frequently noted symptom is forgetfulness in daily life. In older adults, most people do not feel as if their memory is any different than they have had for a few days. Some people's memory may change but only in a short time.\n\nThe brain also has the ability to adapt and change. An individual's abilities change with age, a change in the brain is often observed with normal aging.

Anonymous Patient Answer

What are common treatments for memory loss?

In addition to memory exercise and proper nutrition, cognitive skills and mindfulness, can decrease the cognitive symptoms of dementia to some extent. Cognitively stimulating activities and physical exercise are also helpful to maintain a good general state. If these measures fail, the primary strategy is to promote a healthy lifestyle. A healthy lifestyle includes reducing high-fat, high-sugar, and high-salt food and increasing exercise for at least 30 to 45 minutes per session per day. This should be undertaken with the aim of eliminating risks for memory loss. A balanced diet, sufficient sleep, and mental stimulation are a few techniques that can improve memory.

Anonymous Patient Answer

How many people get memory loss a year in the United States?

In this nationally representative cohort study of individuals aged 50 and older, episodic memory problems were common. Memory problems are more likely when the cause of memory loss (neurological, vascular/cardiovascular, neurologic, or infectious) is not identified.

Anonymous Patient Answer

What are the signs of memory loss?

Symptoms of memory loss include trouble remembering words, things and personal events. Memory loss can be triggered by diseases such as dementia, alcohol and drug use. Memory changes may also be a symptom of a brain injury. Memory loss that develops suddenly can also suggest signs of dementia.\n

Anonymous Patient Answer

Does transcranial alternating current stimulation (tacs) improve quality of life for those with memory loss?

TACS to the hippocampus is safe for this population. TACS has potential to become a treatment modality for the treatment of memory loss. The authors recommend that randomized controlled trials be conducted to establish that tACS can improve memory functioning and improve quality of life for people with dementia and brain aging.

Anonymous Patient Answer

What is the primary cause of memory loss?

Memory loss is usually multifactorial. The main culprits include traumatic episodes in childhood and aging, among which cognitive status might be a contributory factor (Figure 4).

Anonymous Patient Answer

Has transcranial alternating current stimulation (tacs) proven to be more effective than a placebo?

We conclude that alternating current stimulation (ACS) is more effective than control in improving cognitive deficits after TBI. ACS delivered at the time of tDCS may be a reasonable add-on to cognitive rehabilitation protocols in improving functional outcome and brain plasticity.

Anonymous Patient Answer

How serious can memory loss be?

Many people with early-stage Alzheimer's disease go on to develop other serious and sometimes debilitating problems, including stroke or cardiovascular disease, with only 25% surviving 2 years after diagnosis. With some patients, the cause of memory loss can be traced over many years. The most common causes of memory loss without associated dementia are strokes, vascular dementia and Alzheimer's disease. The diagnosis of these diseases may be made early on and can lead to treatment that can slow or reverse the memory problems and may prevent the occurrence of severe cognitive impairment.

Anonymous Patient Answer

What is the latest research for memory loss?

Currently, no new research and treatment strategies have been found to treat memory loss. With the advancement that neuroscience and the medical community receives, more research is expected to be able to find new ways to treat memory losses. It is key that clinical scientists collaborate with neuroscientists and medical doctors in the future to help the general public and medical communities to better understand memory loss. For more information, visit Power (research).

Anonymous Patient Answer

What is transcranial alternating current stimulation (tacs)?

tACS can modify the amplitude of the tACS-induced modulation of the oscillatory entrainment of the human EEG at the beta frequency (10–20 Hz) on the P3 or the alpha rhythm (7.5–10 Hz).

Anonymous Patient Answer
See if you qualify for this trial
Get access to this novel treatment for Memory Loss by sharing your contact details with the study coordinator.