Xenon-129 fMRI for Alzheimer's Disease
This trial uses a special MRI scan with a gas called xenon-129 to get clearer pictures of the brain. It targets people being assessed for brain function to help develop better treatments for Alzheimer's disease. Participants will inhale the gas during the scan, which helps create very detailed images of their brain.
Stem Cell Therapy
Stem Cells + Light Therapy for Alzheimer's Disease and Autism
This trial is testing whether stem cells from patients' own bone marrow can improve cognitive impairment and socialization issues in adults with Alzheimer's or autism. Near-infrared light therapy will also be tested.
Behavioural Intervention
Dysphagia Therapy for Alzheimer's Disease
This trial tests a saliva gel and tongue exercises to help people with Alzheimer's who have trouble swallowing. These patients are at risk of pneumonia because they can't swallow well. The saliva gel keeps their mouth moist, and the exercises make their tongue stronger to help with swallowing.
Popular Filters
Trials for Alzheimer's Disease Patients
PET/MRI Brain Imaging for Alzheimer's Disease
This trial uses a special imaging dye to detect harmful protein build-up in the brains of participants from the UAB Alzheimer's Disease Center. The study aims to understand how these brain changes relate to race, vascular risk factors, and cognitive health. The dye helps make these harmful proteins visible in brain scans.
Behavioural Intervention
Aerobic Exercise for Alzheimer's Disease
This trial tests whether regular aerobic exercise can help prevent dementia in older adults with memory issues. The exercise program aims to improve brain health by boosting blood flow and fitness. Researchers hope to show that this can slow down or prevent cognitive decline.
Trials for AD Patients
PET/MRI Brain Imaging for Alzheimer's Disease
This trial uses a special imaging dye to detect harmful protein build-up in the brains of participants from the UAB Alzheimer's Disease Center. The study aims to understand how these brain changes relate to race, vascular risk factors, and cognitive health. The dye helps make these harmful proteins visible in brain scans.
Behavioural Intervention
Aerobic Exercise for Alzheimer's Disease
This trial tests whether regular aerobic exercise can help prevent dementia in older adults with memory issues. The exercise program aims to improve brain health by boosting blood flow and fitness. Researchers hope to show that this can slow down or prevent cognitive decline.
Phase 3 Trials
MRI + PET Scans for Cognitive Impairment
This trial is studying how well MRI, PET, and cognitive testing work in detecting changes in the brain that may happen before someone shows symptoms of cognitive decline. They will also look at tau protein in the brain with a PET scan and an investigational drug.
Monoclonal Antibodies
Donanemab for Early Alzheimer's Disease
This trial is testing donanemab, a drug for early Alzheimer's disease. It targets people with early symptoms and specific brain changes. The drug helps remove harmful proteins from the brain, potentially slowing down or improving symptoms.
Monoclonal Antibodies
Donanemab for Alzheimer's Disease
This trial is testing donanemab, a medication aimed at helping people with Alzheimer's Disease by removing harmful protein clumps from their brains. Donanemab has shown promise in reducing these harmful proteins in Alzheimer's disease.
Trials With No Placebo
PET/MRI Brain Imaging for Alzheimer's Disease
This trial uses a special imaging dye to detect harmful protein build-up in the brains of participants from the UAB Alzheimer's Disease Center. The study aims to understand how these brain changes relate to race, vascular risk factors, and cognitive health. The dye helps make these harmful proteins visible in brain scans.
Behavioural Intervention
Aerobic Exercise for Alzheimer's Disease
This trial tests whether regular aerobic exercise can help prevent dementia in older adults with memory issues. The exercise program aims to improve brain health by boosting blood flow and fitness. Researchers hope to show that this can slow down or prevent cognitive decline.
Trials Offering Remuneration
Tau PET Imaging for Alzheimer's Disease
This trial is measuring the concentration of pathologic tau deposition in the brain using the PET tracer AV-1451 in participants in the UAB-ADC cohort in order to correlate it with demographic, clinical, genetic, and biospecimen data. The primary outcome of this imaging study is to assess interactions between race and vascular risk factors, brain tau levels measured with AV-1451-PET, and cognitive status.
[18F]3F4AP Imaging for Brain Conditions
This trial is testing the safety of a new imaging agent, [18F]3F4AP, in people with brain injuries, Alzheimer's Disease, and other forms of cognitive impairment. The goal is to see if this agent can help doctors better understand and treat these conditions.
EAAT2 PET Tracer for Dementia
This trial tests a new imaging agent that can be seen with a PET scan to detect early brain changes in patients with Alzheimer's disease and frontotemporal dementia. The agent targets a specific brain protein that is less active in these diseases. By identifying these changes early, doctors hope to improve diagnosis and treatment.
Radiopharmaceutical
Tau Tracer Comparison for Alzheimer's Disease
This trial uses special imaging agents to help visualize harmful brain proteins in people at risk of Alzheimer's disease. The agents make these proteins glow during scans, allowing doctors to see them clearly and monitor the disease.
Radiopharmaceutical
64Cu-FBP8 PET Scan for Alzheimer's Disease
This trial uses a special brain scan to detect certain protein levels in people ranging from normal cognitive function to those with Alzheimer's disease and related dementias. The scan helps researchers understand how these proteins are distributed in the brain.
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Frequently Asked Questions
Introduction to alzheimer disease
What are the top hospitals conducting alzheimer disease research?
When it comes to the battle against Alzheimer's disease, several hospitals are leading the charge in groundbreaking clinical trials. The Boston Center for Memory in Newton is at the forefront with four active trials aimed at understanding and treating this complex condition. This institution has a rich history of 29 completed trials since its first recorded study in 2010. Just down the road, Massachusetts General Hospital in Boston is also heavily involved, currently conducting three Alzheimer's disease trials as part of their ongoing efforts to combat this neurodegenerative disorder. Their commitment dates back even further, with their earliest trial documented back in 1995.
In New york City, NYU Langone Health has made significant strides by initiating three current clinical trials focused on Alzheimer's disease research despite having a comparatively shorter track record—starting only in 2018—and previously holding nine dedicated studies. Down south in Delray Beach, Brain Matters Research is making substantial contributions as well; they too have three ongoing trials targeting Alzheimer’s while having successfully completed an impressive total of sixty-eight previous investigations since their pioneering trial commenced nearly two decades ago--in2003.Finally,in Fort Myers,the Neuropsychiatric Research Center of Southwest Florida rounds out this list with another trio of active clinical trials for Alzheimer's disease after recording thirty-one prior ones from starting off just over ten years ago-in2009.
These institutions signify hope not only for those affected by Alzheimer’s but also represent milestones achieved through medical advancements and tireless dedication. As we witness these top hospitals united against a formidable foe like dementia spectrum disorders,it reiterates that each patient enrolled brings us closer to unraveling new treatments and preventive measures which could positively impact countless lives around the globe
Which are the best cities for alzheimer disease clinical trials?
Miami, Florida; New york, New York; Toronto, Ontario; Indianapolis, Indiana; and Boston, Massachusetts are recognized as the best cities for Alzheimer's disease clinical trials. Miami leads with 18 active trials investigating treatments like Group A - Active Comparator, LY3372689, and Simufilam. Following closely behind is New York with 11 ongoing studies focusing on LX1001, DREEM 2 Headband, and LY3372689. Toronto ranks third with 10 active trials exploring Nabilone and Simufilam among others. Lastly, both Indianapolis and Boston offer valuable contributions to Alzheimer's research through their respective eight ongoing studies centered around interventions such as Donanemab and Gamma therapies.
Which are the top treatments for alzheimer disease being explored in clinical trials?
Exciting advancements in Alzheimer's disease research are underway, with several top treatments undergoing exploration in clinical trials. Leading the charge is LX1001, a promising intervention currently being tested in two active trials. This innovative treatment made its debut on the scene in 2019 and has already garnered attention with two all-time Alzheimer's disease trials under its belt. Another contender making waves is an Intervention technique that entered the stage in 2016 and is also participating in two ongoing trials. Additionally, researchers are investigating Blood Brain Barrier (BBB) Disruption as a potential breakthrough for this debilitating condition through two active studies since 2018. Finally, Supplemental Oxygen therapy has recently emerged on the radar with one current trial aimed at exploring its efficacy against Alzheimer's disease—marking it as an exciting avenue to watch out for moving forward.
What are the most recent clinical trials for alzheimer disease?
Recent clinical trials offer hope for individuals affected by Alzheimer's disease, a debilitating condition that impacts cognition and memory. Among these trials is RB-ADSC low dose, which has entered Phase 1 testing as of August 14th, 2023. Additionally, the experimental drug BRIV demonstrates potential in combating Alzheimer's, with its ongoing Phase 1 and Phase 2 studies since June 1st, 2023. LX1001 is another promising candidate currently undergoing Phase 1 testing after becoming available on May 8th, 2023. Furthermore, researchers are exploring the benefits of Cardio-Dance Fitness in managing symptoms associated with Alzheimer's through a Phase 2 trial launched on April11th ,2023. These efforts signify significant progress towards better understanding and treating this complex neurodegenerative disorder.
What alzheimer disease clinical trials were recently completed?
Several recent clinical trials have made significant strides in the search for effective treatments for Alzheimer's disease. In July 2022, Merck Sharp & Dohme LLC completed a trial investigating the potential of MK-8189. Additionally, Alzamend Neuro, Inc. successfully concluded their AL 001 trial in May 2022, alongside Virogenics, Inc., which finished their CMS121 trial during the same month. Furthermore, TrueBinding, Inc.'s TB006 study reached completion in October 2021 and Acumen Pharmaceuticals wrapped up their ACU193 trial in June 2021. These important advancements highlight ongoing efforts to combat Alzheimer's disease and provide hope to individuals impacted by this devastating condition.