Buntanetap for Alzheimer's Disease
What You Need to Know Before You Apply
What is the purpose of this trial?
The goal of this clinical trial is to learn if buntanetap/Posiphen works to treat early Alzheimer's disease in adults aged 55-85. It will also learn about the safety of buntanetap/Posiphen. The main questions it aims to answer are:* Does buntanetap/Posiphen improve cognition as measured by ADAS-Cog13?* Does buntanetap/Posiphen improve function as measured by ADCS-iADL?* What medical issues do participants have, if any, when taking buntanetap/Posiphen?Researchers will compare buntanetap/Posiphen to a placebo (a look-alike substance that contains no drug) to see if buntanetap/Posiphen works to treat early Alzheimer's disease.Participants will:* Take buntanetap/Posiphen or a placebo every day for 18 months* Visit the clinic periodically for checkups, tests, and questionnaires (screening visits, enrollment, month 1, month 3, month 6, month 9, month 12, month 15, month 18), including a volumetric MRI at month 6 and month 18* Complete pre- and post-clinic visit phone calls
Will I have to stop taking my current medications?
The trial requires that your current medications be stable for at least 4 weeks before starting. Some medications are allowed, like cholinesterase inhibitors and certain mood stabilizers, but strong CYP3A4 inhibitors or inducers are not permitted. Check with the trial team to see if your specific medications are allowed.
Are You a Good Fit for This Trial?
Adults aged 55-85 with early Alzheimer's Disease (AD) can join this trial. They must have an MMSE score of 21-28, a specific CDR score indicating memory issues, and MRI results consistent with AD. Participants need to show amyloid beta presence in their blood.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants take buntanetap/Posiphen or a placebo every day for 18 months
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Buntanetap
Find a Clinic Near You
Who Is Running the Clinical Trial?
Annovis Bio Inc.
Lead Sponsor
Prevail Infoworks, Inc
Collaborator
Prevail Infoworks
Industry Sponsor