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Behavioural Intervention

Exercise + Brain Stimulation for Vascular Cognitive Impairment (EXPRESS-V Trial)

N/A

Recruiting

Led By Krista Lanctôt, PhD

Research Sponsored by Sunnybrook Health Sciences Centre

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

≥50 years of age; females must be post-menopausal

Presence of cerebrovascular and/or cardiovascular risk factors or coronary artery disease

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 2 weeks

Awards & highlights

EXPRESS-V Trial Summary

This trial will compare the effects of exercise and brain stimulation on memory in patients who have completed cardiac rehab and are at risk for cognitive decline.

Who is the study for?

This trial is for English-speaking adults over 50, especially post-menopausal women, with cardiovascular risks or disease and mild memory issues. They must be able to exercise moderately but can't have had a stroke, recent psychotropic medication changes, benzodiazepine use, metal implants affecting brain stimulation safety, or significant neurological/psychiatric conditions.Check my eligibility

What is being tested?

The study tests if exercising before brain stimulation (tDCS) improves memory in those at risk of cognitive decline after cardiac rehab. It compares the combination of exercise and tDCS against sham stimulation and usual treatment to see which is more effective.See study design

What are the potential side effects?

Possible side effects may include discomfort from the tDCS device like itching or tingling on the scalp, fatigue from moderate exercise, and potential muscle soreness.

EXPRESS-V Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am over 50 and, if female, I am post-menopausal.

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I have heart disease or risk factors for stroke or heart disease.

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My cognitive test score is below 27.

EXPRESS-V Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 2 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~2 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Montreal Cognitive Assessment - Global Cognition

Secondary outcome measures

Behavioural measures

Cognitive domains

EXPRESS-V Trial Design

4Treatment groups

Experimental Treatment

Group I: Treatment as usual (exercise education) & tDCSExperimental Treatment2 Interventions

Individuals randomized to this group will receive routine advice about physical activity, and active tDCS.

Group II: Treatment as usual (exercise education) & sham stimulationExperimental Treatment2 Interventions

Individuals randomized to this group will receive routine advice about physical activity, and sham tDCS.

Group III: Exercise primed tDCSExperimental Treatment2 Interventions

Individuals randomized to this group will receive exercise at University Health Network-Toronto Rehabilitation Institute followed by active tDCS.

Group IV: Exercise primed Sham stimulationExperimental Treatment2 Interventions

Individuals randomized to this group will receive exercise at University Health Network-Toronto Rehabilitation Institute followed by sham tDCS.

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

Sunnybrook Health Sciences CentreLead Sponsor

656 Previous Clinical Trials

1,551,228 Total Patients Enrolled

1 Trials studying Vascular Cognitive Impairment

345 Patients Enrolled for Vascular Cognitive Impairment

Krista Lanctôt, PhDPrincipal InvestigatorSunnybrook Research Institute

2 Previous Clinical Trials

221 Total Patients Enrolled

Media Library

Exercise (Behavioural Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT05079464 — N/A

Vascular Cognitive Impairment Research Study Groups: Treatment as usual (exercise education) & sham stimulation, Exercise primed Sham stimulation, Treatment as usual (exercise education) & tDCS, Exercise primed tDCS

Vascular Cognitive Impairment Clinical Trial 2023: Exercise Highlights & Side Effects. Trial Name: NCT05079464 — N/A

Exercise (Behavioural Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05079464 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this experiment open to new participants?

"Affirmative. The clinicaltrials.gov site evinces that this research is presently enrolling participants, beginning from the date of its initial posting on November 22nd 2021 and most recently updated February 25th 2022. This trial expects to recruit 80 individuals from one medical centre."

Answered by AI

How many people are participating in the experiment at its peak?

"Affirmative. Information posted on clinicaltrials.gov implies that this study is currently accepting candidates. It was first published on November 22nd 2021, and the latest update to its details occurred February 25th 2022. This trial needs 80 patients from a single site for participation."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Exercise as a Primer for Brain Stimulation in Vascular Cognitive Impairment No Dementia (VCIND)

2021. "Exercise as a Primer for Brain Stimulation in Vascular Cognitive Impairment No Dementia (VCIND)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05079464.

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