tACS for Depression (GLADIATOR2 Trial)

"This trial is seeking patients aged between 18 and 70 years old to participate."

"The main outcome of this trial, evaluated at Baseline and Day 5, will be the alteration in left frontal alpha oscillation amplitudes measured through eyes-open EEG recordings. Secondary objectives include exploring correlations between changes in depression symptoms determined by Hamilton Depression Rating Scale (HDRS) scores from Baseline to two weeks post treatment with variations in above mentioned amplitude as well as a correlation analysis between change in amplitude values at baseline and day 5. Fourier transformation is used on 2 second signal epochs collected during resting state for calculating these amplitudes which are then averaged over all left frontal electrodes."

"Affirmative. According to clinicaltrials.gov, the research project was made public on June 9th 2021 and has recently been updated on May 10th 2022. 20 patients are required for participation from a single location across the country."

"This trial is presently recruiting patients, as recorded on clinicaltrials.gov. It was initially published on June 9th 2021 and underwent its most recent update May 10th 2022."

"This clinical trial is enrolling 20 volunteers between 18 and 70 years old with a DSM-IV diagnosis of major depressive disorder. To be considered, the applicant must have an HRDS-17 score higher than 8, demonstrate low suicide risk on the HDRS-17 and C-SSRS assessments, as well as possess enough mental capacity to comprehend all associated risks and benefits (informed consent)."