Semantic Dementia Clinical Trials 2023

Browse 52 Semantic Dementia Medical Studies Across 48 Cities

4 Phase 3 Trial · 114 Semantic Dementia Clinics

Reviewed by Michael Gill, B. Sc.
10 Semantic Dementia Clinical Trials Near Me
Top Hospitals for Semantic Dementia Clinical Trials
Image of University of Pennsylvania in Pennsylvania.
University of Pennsylvania
Philadelphia
7Active Trials
23All Time Trials for Semantic Dementia
2003First Semantic Dementia Trial
Image of Mayo Clinic in Minnesota.
Mayo Clinic
Rochester
6Active Trials
15All Time Trials for Semantic Dementia
2008First Semantic Dementia Trial
Image of Massachusetts General Hospital in Massachusetts.
Massachusetts General Hospital
Boston
4Active Trials
10All Time Trials for Semantic Dementia
2011First Semantic Dementia Trial
Image of Johns Hopkins Hospital in Maryland.
Johns Hopkins Hospital
Baltimore
4Active Trials
5All Time Trials for Semantic Dementia
2007First Semantic Dementia Trial
Image of University of California, San Francisco in California.
University of California, San Francisco
San Francisco
3Active Trials
7All Time Trials for Semantic Dementia
2014First Semantic Dementia Trial
Top Cities for Semantic Dementia Clinical Trials
Image of San Francisco in California.
San Francisco
11Active Trials
University of California, San FranciscoTop Active Site
Image of Philadelphia in Pennsylvania.
Philadelphia
10Active Trials
University of PennsylvaniaTop Active Site
Semantic Dementia Clinical Trials by Phase of TrialSemantic Dementia Clinical Trials by Age Group
< 18 Semantic Dementia Clinical Trials
1Active Semantic Dementia Clinical Trials
Most Recent Semantic Dementia Clinical TrialsTop Treatments for Semantic Dementia Clinical Trials
Treatment Name
Active Semantic Dementia Clinical Trials
All Time Trials for Semantic Dementia
First Recorded Semantic Dementia Trial
AL001
2
3
2018
Algorithmically Matched
1
1
2023
Bilateral subgenual cingulate deep brain stimulation (SGC DBS)
1
1
2023
Care Ecosystem
1
1
2023
Intervention arm
1
1
2023
Recently Completed Studies with FDA Approved Treatments for Semantic Dementia
Treatment
Year
Sponsor
Lithium Carbonate
2017
Columbia University

What Are Semantic Dementia Clinical Trials?

Semantic dementia is a brain disorder that may be the cause of younger onset dementia. The disorder occurs when nerve cells in the brain are lost, causing the frontal and temporal lobes to get smaller in size. Semantic dementia can affect language, movement, personality, and behavior. People with semantic dementia often have small structures called pick bodies containing tau proteins.

Experts believed that some cases of semantic dementia are inherited, although most people with the disorder don’t have any family history of the condition. More semantic dementia clinical trials are needed to help practitioners with an accurate diagnosis, prevention, and treatment of the disorder.

Why Is Semantic Dementia Being Studied Through Clinical Trials?

Semantic dementia clinical trials focus on understanding how the disorder works, why it develops, and how to treat it effectively. More importantly, there is a focus on how practitioners can improve the lives of patients with the disorder.

It is only through clinical research that the cause of semantic dementia can be properly understood, laying the groundwork for newer treatments and even potential cures that can improve the quality of life for patients.

What Are The Types of Treatments Available For Semantic Dementia?

There is no treatment available to cure or slow the progression of semantic dementia. However, doctors may prescribe medications to manage the symptoms of the disorder. Commonly prescribed medications include antidepressants to treat anxiety and manage any negative behaviors such as obsessive compulsive disorder.

Sleeping aids are also used to ease insomnia and improve the quality of a patient’s sleep. Patients may be asked to undergo speech and physical therapy to adjust to the changes caused by semantic dementia.

What Are Some Recent Breakthrough Clinical Trials For Semantic Dementia?

2005: Neurophysiological Tests and Semantic Dementia - This clinical trial compared patients struggling with various forms of dementia, including semantic dementia. Its goal was to provide clinical instruments for diagnosing the different types of dementia, including semantic dementia and Alzheimer’s disease.

2019: Testing tDCS in Semantic Dementia - The objective of this semantic dementia clinic trial is to study the effectiveness of transcranial direct current stimulation (tDCS) on language impairment. The results of the study were used to seek better treatments for semantic disorders that are both accessible and inexpensive.

Who Are Some Of The Key Opinion Leaders Semantic Dementia Clinical Trial Research?

Clara Sanches is a postdoctoral fellow at the University of California San Francisco. She specializes in cognitive neurosciences and the use of transcranial stimulation as a possible treatment for dementia. Sanches observes how different individuals respond to aging in various aspects of their life to explore various treatment methods that can prevent early cognitive and functional decline.

Richard Levy is an Assistant Professor of Medicine at Boston University. He is a leading researcher in frontotemporal dementia with over 10 years of experience. Levy has taken part in a number of research papers to discover new treatment methods.

About The Author

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 30th, 2021

Last Reviewed: August 31st, 2023

References1 Rosenbek JC, Robbins JA, Roecker EB, Coyle JL, Wood JL. A penetration-aspiration scale. Dysphagia. 1996 Spring;11(2):93-8. https://pubmed.ncbi.nlm.nih.gov/87210662 Rosenbek JC, Robbins JA, Roecker EB, Coyle JL, Wood JL. A penetration-aspiration scale. Dysphagia. 1996 Spring;11(2):93-8. doi: 10.1007/BF00417897. https://pubmed.ncbi.nlm.nih.gov/87210663 Jack CR Jr, Bennett DA, Blennow K, Carrillo MC, Dunn B, Haeberlein SB, Holtzman DM, Jagust W, Jessen F, Karlawish J, Liu E, Molinuevo JL, Montine T, Phelps C, Rankin KP, Rowe CC, Scheltens P, Siemers E, Snyder HM, Sperling R; Contributors. NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease. Alzheimers Dement. 2018 Apr;14(4):535-562. doi: 10.1016/j.jalz.2018.02.018. https://pubmed.ncbi.nlm.nih.gov/296536064 Jack CR Jr, Bennett DA, Blennow K, Carrillo MC, Dunn B, Haeberlein SB, Holtzman DM, Jagust W, Jessen F, Karlawish J, Liu E, Molinuevo JL, Montine T, Phelps C, Rankin KP, Rowe CC, Scheltens P, Siemers E, Snyder HM, Sperling R; Contributors. NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease. Alzheimers Dement. 2018 Apr;14(4):535-562. doi: 10.1016/j.jalz.2018.02.018. Review. https://pubmed.ncbi.nlm.nih.gov/296536065 Crary MA, Mann GD, Groher ME. Initial psychometric assessment of a functional oral intake scale for dysphagia in stroke patients. Arch Phys Med Rehabil. 2005 Aug;86(8):1516-20. doi: 10.1016/j.apmr.2004.11.049. https://pubmed.ncbi.nlm.nih.gov/160848016 Cedarbaum JM, Stambler N, Malta E, Fuller C, Hilt D, Thurmond B, Nakanishi A. The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (Phase III). J Neurol Sci. 1999 Oct 31;169(1-2):13-21. https://pubmed.ncbi.nlm.nih.gov/105400027 Crary MA, Mann GD, Groher ME. Initial psychometric assessment of a functional oral intake scale for dysphagia in stroke patients. Arch Phys Med Rehabil. 2005 Aug;86(8):1516-20. https://pubmed.ncbi.nlm.nih.gov/160848018 Cedarbaum JM, Stambler N, Malta E, Fuller C, Hilt D, Thurmond B, Nakanishi A. The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (Phase III). J Neurol Sci. 1999 Oct 31;169(1-2):13-21. doi: 10.1016/s0022-510x(99)00210-5. https://pubmed.ncbi.nlm.nih.gov/105400029 Tsapkini K, Frangakis C, Gomez Y, Davis C, Hillis AE. Augmentation of spelling therapy with transcranial direct current stimulation in primary progressive aphasia: Preliminary results and challenges. Aphasiology. 2014;28(8-9):1112-1130. https://pubmed.ncbi.nlm.nih.gov/2609727810 Tsapkini K, Frangakis C, Gomez Y, Davis C, Hillis AE. Augmentation of spelling therapy with transcranial direct current stimulation in primary progressive aphasia: Preliminary results and challenges. Aphasiology. 2014;28(8-9):1112-1130. doi: 10.1080/02687038.2014.930410. https://pubmed.ncbi.nlm.nih.gov/26097278