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Propranolol for Primary Progressive Aphasia

Q: Is enrollment still open for this clinical experiment?

<p>According to clinicaltrials.gov the trial which began its recruitment process on November 1st 2023 is no longer recruiting participants, however there are currently 138 other trials that require volunteers.</p>

Phase < 1

Recruiting

Led By David Beversdorf, MD

Research Sponsored by University of Missouri-Columbia

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age: 50 and older

Native English speaker

Timeline

Screening 3 weeks

Treatment Varies

Follow Up day 1, 4 weeks, 8 weeks, 10 weeks,14 weeks,18 weeks

Awards & highlights

Study Summary

This trial is testing whether Propranolol can improve language symptoms and reduce anxiety in people with Primary Progressive Aphasia.

Who is the study for?

This trial is for individuals aged 50 or older who have been diagnosed with Primary Progressive Aphasia and are native English speakers. It's not suitable for those with major head trauma, untreated hypothyroidism, certain heart conditions like bradyarrhythmia, unexplained fainting episodes, diabetes, reactive airway diseases or those on conflicting medications.Check my eligibility

What is being tested?

The study tests if Propranolol can improve language abilities in people with Primary Progressive Aphasia. Participants will either receive Propranolol or a placebo (a substance with no therapeutic effect). Their language function will be monitored using MRI scans to observe any changes.See study design

What are the potential side effects?

Propranolol may cause side effects such as slow heartbeat, low blood pressure, fatigue, dizziness upon standing up too quickly and could potentially worsen symptoms of asthma or other breathing disorders.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am 50 years old or older.

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I am a native English speaker.

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I have been diagnosed with Primary Progressive Aphasia.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ day 1, 4 weeks, 8 weeks, 10 weeks,14 weeks,18 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~day 1, 4 weeks, 8 weeks, 10 weeks,14 weeks,18 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and day 1, 4 weeks, 8 weeks, 10 weeks,14 weeks,18 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in Neuropsychological Assessment Battery Naming Test

Secondary outcome measures

Change in Semantic Word Fluency Tasks

Change in State-Trait Anxiety Inventory for Adults

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Propanolol and MRIExperimental Treatment2 Interventions

Participants will receive propranolol via oral capsule. The drug dosage will be titrated slowly to ensure the drug is tolerated well.

Group II: Placebo and MRIPlacebo Group2 Interventions

Participants will receive placebo via oral capsule.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Propranolol

2010

Completed Phase 4

~1290

Magnetic Resonance Imaging (MRI)

2015

Completed Phase 4

~1800

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of Missouri-ColumbiaLead Sponsor

362 Previous Clinical Trials

628,094 Total Patients Enrolled

David Beversdorf, MDPrincipal InvestigatorUniversity of Missouri-Columbia

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is enrollment still open for this clinical experiment?

"According to clinicaltrials.gov the trial which began its recruitment process on November 1st 2023 is no longer recruiting participants, however there are currently 138 other trials that require volunteers."

Answered by AI

Recent research and studies

NeurologyJournal

Classification of Primary Progressive Aphasia and Its Variants

Gorno-Tempini, M. L., A. E. Hillis, S. Weintraub, A. Kertesz, M. Mendez, S. F. Cappa, J. M. Ogar, et al.. 2011. “Classification of Primary Progressive Aphasia and Its Variants”. Neurology. Ovid Technologies (Wolters Kluwer Health). doi:10.1212/wnl.0b013e31821103e6.

clinicaltrials.govStudy

Propranolol in Primary Progressive Aphasia

David Beversdorf 2024. "Propranolol in Primary Progressive Aphasia". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06066710.

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