Thigh Cuffs for Fluid Shift in Healthy Subjects
What You Need to Know Before You Apply
What is the purpose of this trial?
Venoconstrictive Thigh Cuffs (VTC) are being evaluated to determine the effectiveness at reversing the headward fluid shift that occurs during weightlessness. If successful, future studies may be done to implement these as a CM to SANS. To support this effort, participants will participate in 2 preflight study sessions consisting of a VTC fit check and a baseline data collection without and with the VTC donned. Participants will also participate in 3 inflight study sessions: a VTC fit check on flight day 30 (FD30) and two separate data collection sessions on flight day 45 (FD45) and 45 days before landing (R-45). During the two in-flight data collection days, participants will be studied before and for up to 6 hours after donning the VTC.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but if you are using ethinyl estradiol Combined Oral Contraceptive (COC) pills, you cannot participate.
Are thigh cuffs safe for use in humans?
How do thigh cuffs differ from other treatments for fluid shift?
Thigh cuffs are unique because they are worn on the thighs to physically limit the movement of body fluids from the legs to the upper body, which is different from other treatments that might involve medication or other interventions. This method is particularly used in situations like space flight or simulated microgravity to manage fluid distribution without the use of drugs.12567
What data supports the effectiveness of the treatment Venoconstrictive Thigh Cuff (VTC)?
Research shows that venoconstrictive thigh cuffs can help limit fluid shifts in the body during conditions that simulate microgravity, like space travel or bed rest. They help reduce the loss of body water and plasma volume, which can be beneficial in managing symptoms related to fluid redistribution.12578
Who Is on the Research Team?
Brandon R Macias, PhD
Principal Investigator
National Aeronautics and Space Administration (NASA)
Are You a Good Fit for This Trial?
This trial is for healthy individuals who are interested in participating in a study that involves wearing Venoconstrictive Thigh Cuffs (VTC). The cuffs are tested to see if they can counteract fluid movement towards the head in zero gravity, which could help with space-related health issues.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Preflight
Participants undergo VTC fit check and baseline data collection without and with the VTC donned
Inflight
Participants undergo VTC fit check and data collection sessions during the mission
Follow-up
Participants are monitored for safety and effectiveness after the mission
What Are the Treatments Tested in This Trial?
Interventions
- Venoconstrictive Thigh Cuff (VTC)
Find a Clinic Near You
Who Is Running the Clinical Trial?
National Aeronautics and Space Administration (NASA)
Lead Sponsor