Tau PET Imaging for Frontotemporal Dementia
(SLD3 Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial uses a drug called AV-1451 to study its ability to bind to tau proteins in the brains of patients with PPA and FTD. By doing this, researchers hope to better understand tau buildup in these conditions.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but it mentions that you cannot participate if you are on medications that might affect brain structure or metabolism, like chemotherapy.
Is 18F-flortaucipir (Tauvid) safe for use in humans?
How is the drug 18F-flortaucipir used in frontotemporal dementia different from other treatments?
18F-flortaucipir is unique because it is a PET imaging agent that specifically targets tau protein deposits in the brain, which are associated with cognitive impairments. Unlike other treatments that may focus on symptoms, this drug helps visualize tau pathology, aiding in the diagnosis and differentiation of frontotemporal dementia from other conditions like Alzheimer's disease.12467
Who Is on the Research Team?
Keith Josephs, MD
Principal Investigator
Mayo Clinic
Are You a Good Fit for This Trial?
This trial is for adults over 18 who primarily speak English and have progressive speech/language issues or behavior changes, fitting the criteria for Primary Progressive Aphasia or Frontotemporal Dementia. They need someone to independently assess their functioning but can't join if they have other illnesses causing similar symptoms, are pregnant/breastfeeding, mute/unintelligible speech, MRI contraindications like metal implants, severe claustrophobia, brain structure abnormalities or are on certain medications.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Imaging
Participants receive a Tau PET scan using F-18 AV 1451 to assess tau burden in the brain
Follow-up
Participants are monitored for safety and effectiveness after imaging
What Are the Treatments Tested in This Trial?
Interventions
- F-18 AV 1451
Find a Clinic Near You
Who Is Running the Clinical Trial?
Mayo Clinic
Lead Sponsor