Speech and non-speech sound stimulation for Languages

Phase-Based Progress Estimates
University of Pittsburgh, Pittsburgh, PA
Speech and non-speech sound stimulation - Behavioral
< 65
All Sexes
Eligible conditions

Study Summary

This study is evaluating whether the FFR can be used to detect speech encoding problems in people with brain injuries.

See full description

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

This trial is evaluating whether Speech and non-speech sound stimulation will improve 3 primary outcomes in patients with Languages. Measurement will happen over the course of During simultaneous EEG and pupillometry session, up to 3 hours.

Hour 3
Pitch tracking and decoding accuracies for dynamically varying pitch in naturally produced Mandarin tone categories
Stimulus-specific effects in Chinese vs. English participants
Hour 3
Arousal state and predictability effects on the FFRs

Trial Safety

Safety Progress

1 of 3

Trial Design

1 Treatment Group

Neurotypical Human Participants
1 of 1
Experimental Treatment

This trial requires 70 total participants across 1 different treatment group

This trial involves a single treatment. Speech And Non-speech Sound Stimulation is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Neurotypical Human Participants
Native speakers of Chinese and native speakers of English

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: during eeg session, up to 3 hours
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly during eeg session, up to 3 hours for reporting.

Who is running the study

Principal Investigator
B. C.
Prof. Bharath Chandrasekaran, Professor
University of Pittsburgh

Closest Location

University of Pittsburgh - Pittsburgh, PA

Eligibility Criteria

This trial is for patients born any sex aged 65 and younger. There are 7 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Native Mandarin speakers
Hearing sensitivity within normal limits (Puretone hearing thresholds < 25dB from 250
Age 13 years up to 25 years
Healthy volunteers
Native English speaking individuals with no exposure or experience to tonal languages
Hz to 8000 Hz)
Less than six years of formal music training or experience

Patient Q&A Section

What are the signs of languages?

"A variety of neurologic signs are associated with languages. Clinical signs may be limited when the person is unaware that they have a language deficit, or may be absent as a result of neurologic dysfunction, such as stroke or neuromuscular disease. In addition, signs may be absent in individuals with neurologic disorders that involve the same area of the brain, such as multiple sclerosis and subcortical dementias. Furthermore, signs of a language deficit may be transient." - Anonymous Online Contributor

Unverified Answer

What are common treatments for languages?

"The most common treatments for languages are speech therapy, bibliotherapy, telephonic-verbal communication, auditory rehabilitation and fluency, and reading instruction therapies. These are not necessarily the most effective treatment alternatives. Appropriate treatment is recommended for the individual language that is a major obstacle for communication." - Anonymous Online Contributor

Unverified Answer

Can languages be cured?

"The language ability of a communicator may determine whether or not a person with a specific language impairment could be helped with a remediate program. There is an extremely important need for research on why such language impairment occurs and why certain linguistic abilities may help a person with that language impairment more than others (that is, if remediation is needed)." - Anonymous Online Contributor

Unverified Answer

How many people get languages a year in the United States?

"Languages are taught at least once to about 25% of American children and are used at least once a year by more than 60 million U.S. residents. More information is needed about the language abilities of U.S. residents." - Anonymous Online Contributor

Unverified Answer

What is languages?

"The linguistic heterogeneity of the world is reflected in the different languages of the world. The linguistic heterogeneity can lead to a lack of understanding of each other's ways of thinking, interpreting and speaking. However, there are three major language communities, namely the English community, the Francophone community, and the Germanic community. These three communities differ from each other mainly in their attitudes, opinions, habits and way of life. They also have their own linguistic customs, traditions and practices. These differences have contributed to international communication, diplomacy and trade development among these communities. The major implication of linguistic diversity is that the communication of world views and ideas are hampered." - Anonymous Online Contributor

Unverified Answer

What causes languages?

"There is significant genetic influence on the development of languages and many diseases have a language-specific prevalence. In addition, different languages have language-specific symptoms and signs that can provide clues for the cause of a particular disorder. Language disorders also tend to have different treatment strategies and prognoses. \n" - Anonymous Online Contributor

Unverified Answer

Is speech and non-speech sound stimulation typically used in combination with any other treatments?

"The comparison of speech and non-speech sound stimulation suggests their effect on tinnitus. This suggests that a positive effect of tinnitus reduction can be achieved by combining different sounds for both tinnitus patient group and the comparison group." - Anonymous Online Contributor

Unverified Answer

Have there been any new discoveries for treating languages?

"Many of the newly developed drugs seem to be useful in the treatment of aphasia, specifically in the case of the Wernicke-Berger variant of the syndrome." - Anonymous Online Contributor

Unverified Answer

Who should consider clinical trials for languages?

"Language and cultural factors have an impact on patient preference and choice of treatment, and can result in a significant portion of non-English speaking patients not participating in clinical trials. Clinical trials that require patients to read a document may exclude a large proportion of non-English speaking patients without altering compliance rates. There is a need for appropriate translation and culturally sensitive methods. Many countries have already started to include foreign languages in their national Clinical trial laws." - Anonymous Online Contributor

Unverified Answer

Does speech and non-speech sound stimulation improve quality of life for those with languages?

"While our participants reported fewer speech delays attributable to SLI, they reported an improvement in their overall QOL, the largest effect having occurred in relation to social behaviours. It seems that non-speech sound stimulation may be effective for improving the speech perception of those diagnosed with SLI." - Anonymous Online Contributor

Unverified Answer

What is the average age someone gets languages?

"What is the average age a language is learned? answer: In terms of how quickly people acquire languages, there seems to be a threshold at which learning stops and languages becomes more difficult and more complex to learn and acquire. There was also a strong positive correlation between individual age and speed of acquisition. We estimate that languages are learned and mastered about 12–14 years and get a bit faster between age 22 and 32.<ref name="doi10." - Anonymous Online Contributor

Unverified Answer

What are the latest developments in speech and non-speech sound stimulation for therapeutic use?

"In a recent study, findings of this study demonstrate a new approach which allows the treatment of pediatric neurodegenerative disorders by means of adaptive speech stimulation based on individualized sound therapy." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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