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(18F)-FEPPA PET/MRI Imaging for Frontotemporal Dementia

N/A
Recruiting
Research Sponsored by Lawson Health Research Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Visual and auditory acuity adequate for neuropsychological testing
Willing to participate in a longitudinal imaging study at 12 months
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 120 minutes
Awards & highlights

Study Summary

This trial will use hybrid PET/MRI imaging to study neuroinflammation in frontotemporal dementia patients and its relationship to cerebral perfusion.

Who is the study for?
This trial is for individuals diagnosed with probable Frontotemporal Dementia or healthy controls without neurological issues. Participants need a study partner, must be in good health not affecting the study, and women should not be pregnant or of childbearing potential unless properly managed. Exclusions include significant systemic illness, certain medical conditions that affect MRI safety, other major neurologic diseases besides FTD, recent psychiatric disorders, and those exceeding radiation exposure limits.Check my eligibility
What is being tested?
(18F)-FEPPA PET/MRI imaging is being tested to assess neuroinflammation's role in Frontotemporal Dementia (FTD). The trial involves cognitive assessments and advanced imaging techniques to explore the relationship between brain inflammation, blood flow, and brain structure in patients with different subtypes of FTD.See study design
What are the potential side effects?
While the document does not specify side effects related to FEPPA directly since it's an imaging agent used for PET scans; generally such procedures may involve risks from radiation exposure although within safe limits set by health regulations. There might also be discomfort associated with positioning during scanning.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I can see and hear well enough for brain function tests.
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I am willing to join a year-long imaging study.
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I can have an MRI and PET scan and have no health issues preventing them.
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I am not pregnant, breastfeeding, and cannot become pregnant.
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I have been diagnosed with probable Frontotemporal Dementia or I am neurologically healthy with no history of neurological issues.
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I am in good health with no conditions that could affect the study.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~120 minutes
This trial's timeline: 3 weeks for screening, Varies for treatment, and 120 minutes for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Group differences in regional PET FEPPA ligand imaging
Secondary outcome measures
Correlation between PET FEPPA ligand images and specified MR images

Trial Design

1Treatment groups
Experimental Treatment
Group I: (18F)-FEPPAExperimental Treatment1 Intervention

Find a Location

Who is running the clinical trial?

Lawson Health Research InstituteLead Sponsor
656 Previous Clinical Trials
413,454 Total Patients Enrolled
5 Trials studying Frontotemporal Dementia
1,211 Patients Enrolled for Frontotemporal Dementia

Media Library

(18F)-FEPPA Clinical Trial Eligibility Overview. Trial Name: NCT02945774 — N/A
Frontotemporal Dementia Research Study Groups: (18F)-FEPPA
Frontotemporal Dementia Clinical Trial 2023: (18F)-FEPPA Highlights & Side Effects. Trial Name: NCT02945774 — N/A
(18F)-FEPPA 2023 Treatment Timeline for Medical Study. Trial Name: NCT02945774 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the cap on enrollment for this clinical experiment?

"Correct. Based on the details presented on clinicaltrials.gov, this medical experiment is actively recruiting participants and first appeared online August 1st of 2016. Currently, 40 patients are needed from a single site for enrollment in the trial."

Answered by AI

What types of participants is this investigation best suited for?

"To be eligible to enter this clinical trial, the patient must have been diagnosed with semantic dementia and within a certain age range (30-95 years old). The total number of participants that will be accepted is 40."

Answered by AI

Can seniors aged sixty or over participate in this experiment?

"Meet the requirements for this medical trial? Individuals must be between 30 and 95 years old. On the other hand, there are a total of 30 studies available to those under 18 and 423 additional ones targeting people 65 or older."

Answered by AI

Does this research program currently accept participants?

"Affirmative, the trial is presently inviting participants to take part in it. This clinical study was first uploaded on August 1st 2016 and underwent its latest revision on September 2nd 2020. Forty patients are needed at a single medical centre."

Answered by AI
~5 spots leftby Mar 2025