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Speech-Language Therapy for Aphasia

N/A
Recruiting
Led By Aneta Kielar, PhD
Research Sponsored by University of Arizona
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Present with speech-language impairment (aphasia) caused by stroke or dementia
Present with speech-language impairment (aphasia) caused by stroke or dementia
Timeline
Screening 3 weeks
Treatment Varies
Follow Up through study completion, an average of 1 year
Awards & highlights

Study Summary

This trial will investigate the efficacy of language-based treatment for aphasia and its corresponding neural patterns.

Who is the study for?
This trial is for English-speaking adults with aphasia due to stroke or dementia, who can undergo MRI scans and have normal vision and hearing (with aids if needed). It's not for those with severe health issues, claustrophobia, metal implants incompatible with MRI, substance abuse history, recent seizures, brain surgery history, or psychiatric conditions affecting communication.Check my eligibility
What is being tested?
The study compares individualized speech-language training versus standard language intervention in improving communication skills among people with aphasia. It also examines the long-term effects of these treatments and their associated neural patterns through brain imaging.See study design
What are the potential side effects?
Since this trial involves non-invasive language therapy interventions rather than medication or surgical procedures, side effects are minimal but may include fatigue from intensive training sessions and discomfort during MRI scanning.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have difficulty speaking or understanding language due to a stroke or dementia.
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I have difficulty speaking or understanding language due to a stroke or dementia.
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I have difficulty speaking or understanding language due to a stroke or dementia.
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I am a native English speaker.
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I have been diagnosed with primary progressive aphasia by a doctor.
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My vision and hearing are normal or corrected to normal.
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I am a native English speaker.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through study completion, an average of 1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion, an average of 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Aphasia
Mean change from baseline scores on the language probe task before and after each session
Mean change from baseline scores on the naming task

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Active therapy groupExperimental Treatment1 Intervention
Participants will undergo individualized language treatment in which they will learn semantically- or phonologically based strategies to facilitate word finding difficulties, sentence formulation difficulties, or challenges in their narration and discourse. The level at which the treatment will be administered will depend on the participants' level of performance determined by the results of the language and cognitive testing done at baseline. Treatment will be administered twice a week for 10 weeks.
Group II: control groupActive Control1 Intervention
control group will undergo standard speech-language intervention

Find a Location

Who is running the clinical trial?

University of ArizonaLead Sponsor
512 Previous Clinical Trials
148,203 Total Patients Enrolled
Aneta Kielar, PhDPrincipal InvestigatorUniversity of Arizona
2 Previous Clinical Trials
50 Total Patients Enrolled

Media Library

Individualized Speech-Language Training Clinical Trial Eligibility Overview. Trial Name: NCT05443633 — N/A
Primary Progressive Aphasia Research Study Groups: Active therapy group, control group
Primary Progressive Aphasia Clinical Trial 2023: Individualized Speech-Language Training Highlights & Side Effects. Trial Name: NCT05443633 — N/A
Individualized Speech-Language Training 2023 Treatment Timeline for Medical Study. Trial Name: NCT05443633 — N/A
Primary Progressive Aphasia Patient Testimony for trial: Trial Name: NCT05443633 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there still opportunities to sign up for participation in this clinical experiment?

"As per the information hosted on clinicaltrials.gov, this research study is no longer recruiting participants. Initially posted on August 30th 2022 and last revised July 5th 2022, although it is not seeking enrollees currently, 1150 other trials are presently accepting patients."

Answered by AI

Is the age threshold for enrolment into this research trial over 20 years old?

"This medical study has a strict set of eligibility requirements, as applicants must be aged between 21 and 80. By contrast, there are 70 clinical trials available to those below the age of 18 and 1095 for people above 65 years old."

Answered by AI

Is it possible for me to become a participant in this experiment?

"For this medical trial, 30 participants with language-based disabilities aged between 21 and 80 are required. To be eligible for the study, applicants must satisfy certain criteria: Speech impairment as a result of stroke or dementia; A diagnosis of primary progressive aphasia (PPA) from a neurologist or doctor; Native English speakers only; No MRI contraindications; Visual & auditory acuity within normal limits (with correction where necessary)."

Answered by AI

Who else is applying?

What state do they live in?
Indiana
Maryland
What site did they apply to?
University of Arizona
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
0
1
2

Why did patients apply to this trial?

I am applying for my mom with her permission. The aphasia is a daily struggle in addition to the confusion and declining cognitive skills. I would love her to have tools she may pick up while helping others through this study to make her life a bit easier.
PatientReceived 2+ prior treatments
I was diagnosted with ppa 1 1/2 years ago. until recently, I was able to get by with short answers. Now it is difficult. I am stuck. I serch for the word trying out other connections That has not worked. The words are lost and growing. typing is difficult, Now, I can not remember other areas.
PatientReceived no prior treatments

What questions have other patients asked about this trial?

How responsive is this trial?

Average response time
  • < 2 Days
Typically responds via
Phone Call
Most responsive sites:
  1. University of Arizona: < 48 hours
~20 spots leftby Jun 2027