Study Summary
This trial will evaluate the impact of combining zonisamide and bupropion on the process of switching from CCs to an e-cigarette. There will be a data collection period of at least five days to obtain baseline information on the use of CCs. All participants enrolled in the study will receive a JUUL e-cigarette at Visit 2 for ad libitum use. After the first week of e-cigarette use (at Visit 3), participants will be given bupropion (150 mg each morning for days 1-3, then 300 mg daily) with either zonisamide (100 mg daily) or placebo (group 1 and
Treatment Effectiveness
Phase-Based Effectiveness
Study Objectives
3 Primary · 2 Secondary · Reporting Duration: Baseline, Week 1, Week 2, Week 4, Week 8, Week 12
Trial Safety
Phase-Based Safety
Side Effects for
Awards & Highlights
Trial Design
3 Treatment Groups
Combination zonisamide and bupropion with e-cigarette
1 of 3
Bupropion with e-cigarette
1 of 3
Placebo with e-cigarette
1 of 3
Experimental Treatment
Non-Treatment Group
180 Total Participants · 3 Treatment Groups
Primary Treatment: Zonisamide · Has Placebo Group · Phase 3
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 21 - 65 · All Participants · 2 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:Frequently Asked Questions
What is the Zonisamide approval status with the FDA?
"Zonisamide has undergone multiple rounds of clinical trials, indicating that it is a safe medication with some efficacy. Our team ranks it as a 3 on our safety scale." - Anonymous Online Contributor
Are test subjects of this trial restricted to those above 25 years old?
"The target participants for this trial are young adults, aged 21 to 65." - Anonymous Online Contributor
Are there any medical conditions which would make someone ineligible for this research?
"This study is investigating smoking cessation techniques, and as such, participants must be smokers that are aged 21 to 65. Around 180 people will be accepted into the trial." - Anonymous Online Contributor
Is recruitment still underway for patients to participate in this research?
"That is correct. The listing for the trial on clinicaltrials.gov shows that it is still seeking participants, with 180 patients needed at 2 locations. The study was first posted on December 14th, 2021 and last updated on August 22nd, 2022." - Anonymous Online Contributor