40 Participants Needed

Stress Management Program for Von Hippel-Lindau Syndrome

GP
Overseen ByGiselle Perez, PhD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Massachusetts General Hospital
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

The Relaxation Response Resiliency Program (3RP) has shown efficacy in improving coping and resilience across diverse populations; however, little is known about how it helps individuals manage the challenges of living with a chronic illness. This study proposes to pilot test an adapted version of the 3RP among patients living with VHL.

Do I need to stop my current medications for this trial?

The trial information does not specify whether you need to stop taking your current medications. It seems focused on stress management, so it's likely you can continue your medications, but please confirm with the study team.

How does the 3RP-VHL treatment differ from other treatments for Von Hippel-Lindau Syndrome?

The 3RP-VHL treatment is unique because it focuses on stress management and resilience training, which can improve quality of life and reduce stress and anxiety, unlike traditional treatments that may not address these psychological aspects.12345

What evidence supports the effectiveness of the stress management treatment 3RP-VHL for Von Hippel-Lindau Syndrome?

Research on stress management in cancer patients shows that managing stress can improve psychological well-being and potentially lead to better health outcomes. This suggests that similar stress management programs might help people with Von Hippel-Lindau Syndrome by improving their quality of life and health.26789

Who Is on the Research Team?

GP

Giselle Perez, PhD

Principal Investigator

Massachusetts General Hospital

Are You a Good Fit for This Trial?

This trial is for adults over 18 with a confirmed diagnosis of Von Hippel-Lindau (VHL) disease, which is a genetic disorder. Participants must be able to engage in videoconferencing sessions and not have any medical or psychiatric conditions that would prevent full participation as assessed by a physician.

Inclusion Criteria

I have been diagnosed with Von Hippel-Lindau disease.

Exclusion Criteria

My doctor agrees I am fit to join a study.
Participated in Phase 1 qualitative interview
I am willing and able to attend sessions through video calls.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Phase I - Descriptive

Conducting interviews with patients and caregivers to understand the challenges of living with VHL and patient's programmatic needs

Not specified

Phase II - Treatment

Testing the adapted 3RP-VHL program in up to 40 patients with weekly sessions over approximately 8 weeks

8 weeks
8 weekly sessions

Follow-up

Participants are monitored for feasibility and acceptability outcomes post-treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • 3RP-VHL
Trial Overview The study tests an adapted Relaxation Response Resiliency Program (3RP-VHL), designed to help VHL patients cope better with their condition. It's about learning stress management techniques specifically tailored for those living with this chronic illness.
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: 3RP-VHLExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Massachusetts General Hospital

Lead Sponsor

Trials
3,066
Recruited
13,430,000+

The Rappaport Foundation

Collaborator

Trials
1
Recruited
40+

The Claflin Distinguished Scholar Awards

Collaborator

Trials
1
Recruited
40+

Published Research Related to This Trial

Cancer patients experience significant stress that can negatively impact their quality of life and may even promote tumor growth and metastasis, highlighting the importance of effective stress management.
Randomized controlled trials have shown that stress management interventions can improve psychological and physiological adaptation, potentially leading to better health outcomes for cancer patients and survivors.
Stress Management Interventions to Facilitate Psychological and Physiological Adaptation and Optimal Health Outcomes in Cancer Patients and Survivors.Antoni, MH., Moreno, PI., Penedo, FJ.[2023]
The SMART (Stress Management and Resiliency Training) program significantly improved resilience, reduced perceived stress and anxiety, and enhanced quality of life in 25 women with breast cancer over a 12-week period, compared to a control group.
The intervention, which included group training sessions and follow-up calls, was found to be feasible and effective, indicating that brief resilience training can be beneficial for breast cancer patients.
Stress Management and Resilience Training (SMART) program to decrease stress and enhance resilience among breast cancer survivors: a pilot randomized clinical trial.Loprinzi, CE., Prasad, K., Schroeder, DR., et al.[2022]
A 20-week contemplative self-healing program significantly improved the quality of life (QOL) for 46 breast and gynecologic cancer survivors, as evidenced by a mean increase of 6.4 points on the FACIT-G scale.
Participants also experienced notable reductions in anxiety and distress, along with biological improvements such as lower resting heart rates and better cortisol levels, indicating enhanced emotional and physical well-being.
The effect of a contemplative self-healing program on quality of life in women with breast and gynecologic cancers.Loizzo, JJ., Peterson, JC., Charlson, ME., et al.[2022]

Citations

Stress Management Interventions to Facilitate Psychological and Physiological Adaptation and Optimal Health Outcomes in Cancer Patients and Survivors. [2023]
Functional and neuropsychological late outcomes in posterior fossa tumors in children. [2018]
Craniopharyngioma in Children: Long-term Outcomes. [2018]
Diurnal cortisol rhythms, fatigue and psychosocial factors in five-year survivors of ovarian cancer. [2018]
Effect of chronic stress on tumorigenesis and development. [2022]
Stress Management and Resilience Training (SMART) program to decrease stress and enhance resilience among breast cancer survivors: a pilot randomized clinical trial. [2022]
Social Support, Coping, and Cancer-Related Health Burden in Long-term Survivors Treated with Hematopoietic Stem Cell Transplantation as Adolescents or Young Adults. [2023]
Investigating the Hypothesis of Stress System Dysregulation as a Risk Factor for Central Serous Chorioretinopathy: A Literature Mini-Review. [2020]
The effect of a contemplative self-healing program on quality of life in women with breast and gynecologic cancers. [2022]
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