Exercise + Immunotherapy for Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
30 minutes of moderate exercise on an arm ergometer, a cycle ergometer, or a treadmill prior to each administration of standard of care checkpoint blockade immunotherapy across all cycles
Will I have to stop taking my current medications?
The trial protocol does not specify whether you need to stop taking your current medications. However, it mentions that participants should be scheduled for first-time checkpoint blockade immunotherapy without other therapies, which might imply some restrictions.
Is the combination of exercise and immunotherapy generally safe for humans?
Checkpoint inhibitors, a type of immunotherapy, can cause immune-related side effects, including bone fractures and endocrine issues, by activating the immune system against normal tissues. Exercise's impact on these side effects is not well understood, but it is important to monitor for these potential adverse events during treatment.12345
How does the treatment of exercise combined with checkpoint blockade immunotherapy differ from other cancer treatments?
This treatment is unique because it combines exercise with checkpoint blockade immunotherapy, which may enhance the immune system's ability to fight cancer by improving immune cell circulation and tumor blood flow, potentially overcoming resistance seen in some cancers with immunotherapy alone.678910
What data supports the effectiveness of the treatment combining exercise and checkpoint blockade immunotherapy for cancer?
Who Is on the Research Team?
Peter Kanetsky, PhD, MPH
Principal Investigator
Moffitt Cancer Center
Are You a Good Fit for This Trial?
This trial is for adults who can read and speak English, give informed consent, and are able to do moderate exercise like walking unaided for at least six minutes. It's specifically for those with certain skin cancers or neuroendocrine carcinoma about to start checkpoint blockade immunotherapy. People with severe heart disease or major postoperative complications cannot join.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Neoadjuvant Treatment
Participants receive up to 4 cycles of checkpoint blockade immunotherapy with or without exercise
Adjuvant Treatment
Participants receive 9-18 cycles of checkpoint blockade immunotherapy with or without exercise
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Checkpoint Blockade Immunotherapy
- Exercise
Find a Clinic Near You
Who Is Running the Clinical Trial?
H. Lee Moffitt Cancer Center and Research Institute
Lead Sponsor