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Procedure

Ovarian Tissue Transplantation for Female Infertility

N/A
Recruiting
Led By Clarisa R Gracia, MD
Research Sponsored by Abramson Cancer Center of the University of Pennsylvania
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Female patient between the ages of 18 and 45 years
Previously cryopreserved and stored cortical ovarian tissue available for autologous transplantation
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 5 years
Awards & highlights

Study Summary

This trial is testing whether ovarian tissue that has been frozen can be thawed and transplanted back to the patient, restoring fertility. The trial is also testing the safety of this procedure.

Who is the study for?
This trial is for women aged 18-45 who have become infertile or have ovarian insufficiency due to cancer treatments. They must have their own frozen ovarian tissue, be in good health, and unable to conceive naturally after trying for 6 months. Women with high surgical risk, current pregnancy, BRCA mutation, certain cancers or mental conditions affecting consent are excluded.Check my eligibility
What is being tested?
The study tests the safety and effectiveness of transplanting a woman's own previously frozen ovarian tissue back into her body. This aims to restore fertility in those affected by infertility or ovarian failure post-cancer treatment.See study design
What are the potential side effects?
Potential side effects may include complications from surgery such as infection or bleeding, hormonal changes due to restored ovarian function, and possible re-introduction of cancer cells if present in the transplanted tissue.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am a woman aged between 18 and 45.
Select...
I have my ovarian tissue frozen for future use.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Pregnancy
Return of menstrual function
Secondary outcome measures
Acceptability
Cancer recurrence
Surgical Complications of ovarian tissue transplantation

Trial Design

1Treatment groups
Experimental Treatment
Group I: Transplantation of previously cryopreserved ovarian tissueExperimental Treatment1 Intervention
Surgical transplantation of previously collected cryopreserved ovarian cortical tissue.

Find a Location

Who is running the clinical trial?

Abramson Cancer Center of the University of PennsylvaniaLead Sponsor
359 Previous Clinical Trials
105,054 Total Patients Enrolled
Abramson Cancer Center at Penn MedicineLead Sponsor
387 Previous Clinical Trials
145,654 Total Patients Enrolled
Clarisa R Gracia, MDPrincipal InvestigatorAbramson Cancer Center at Penn Medicine

Media Library

Transplantation of previously cryopreserved ovarian tissue (Procedure) Clinical Trial Eligibility Overview. Trial Name: NCT01870752 — N/A
Female Infertility or Ovarian Insufficiency. Research Study Groups: Transplantation of previously cryopreserved ovarian tissue
Female Infertility or Ovarian Insufficiency. Clinical Trial 2023: Transplantation of previously cryopreserved ovarian tissue Highlights & Side Effects. Trial Name: NCT01870752 — N/A
Transplantation of previously cryopreserved ovarian tissue (Procedure) 2023 Treatment Timeline for Medical Study. Trial Name: NCT01870752 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many individuals are included in the scope of this clinical trial?

"Affirmative. The clinicaltrials.gov's data confirms that this experiment is presently in search of participants, with the initial posting on June 1st 2013 and last update occurring on August 31st 2021. They are seeking 10 volunteers at a single medical centre."

Answered by AI

Is this research actively recruiting participants?

"According to the data on clinicaltrials.gov, this experimental trial is actively recruiting participants from its inception date of June 1st 2013 up until present day. The study's details have been consistently updated since then, with the most recent change being made in August 2021."

Answered by AI

Who is most ideally suited to enroll in this trial?

"For admission to this clinical experiment, infertile females or ladies with ovarian inadequacy must register and be between 18 and 45 years of age. The trial has capacity for 10 participants in total."

Answered by AI

Does this investigation extend to individuals over 35 years of age?

"The minimum age requirement for participants in this trial is 18 years old and the cutoff to be eligible is 45."

Answered by AI

Who else is applying?

What state do they live in?
New Jersey
How old are they?
18 - 65
What site did they apply to?
Abramson Cancer Center of the University of Pennsylvania
What portion of applicants met pre-screening criteria?
Met criteria

How responsive is this trial?

Typically responds via
Phone Call
Most responsive sites:
  1. Abramson Cancer Center of the University of Pennsylvania: < 24 hours
Average response time
  • < 1 Day
Recent research and studies
clinicaltrials.govStudy
Ovarian Tissue Transplantation
2013. "Ovarian Tissue Transplantation". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01870752.
All > Infertility > Pennsylvania
~3 spots leftby Jun 2028
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