CBD Oil for Scar Healing

Not yet recruiting at 1 trial location

Overseen By Lead Nurse

Age: 18+

Sex: Any

Trial Phase: Phase 1

Sponsor: University of Oklahoma

Disqualifiers: Under 18, CBD allergy

Compensation: Varies

Number of Visits: Unknown

Duration: 6 months

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests whether CBD oil can improve scar healing and appearance for individuals who have undergone a specific type of facial surgery. Researchers aim to observe both the positive and negative effects of CBD oil on scars. Participants will receive treatment on their forehead scar with either CBD oil or a silicone patch. English-speaking adults who have had this surgery may qualify. As a Phase 1 trial, the research focuses on understanding how the treatment works in people, offering participants the opportunity to be among the first to receive this innovative treatment.

Do I need to stop my current medications to join the trial?

The trial information does not specify whether you need to stop taking your current medications.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Research shows that CBD oil is usually safe when applied to the skin. Studies have found that it can reduce swelling and aid in wound healing without major side effects. For instance, one study reported no significant skin reactions and only mild irritation in some cases. This suggests that CBD oil is likely safe for use on scars. However, as this trial is still in the early stages, more research is needed to confirm its safety for everyone. Prospective participants should know that current evidence suggests CBD oil is gentle on the skin. ^{1 2 3 4 5}

Why do researchers think this study treatment might be promising for scar healing?

Most treatments for scar healing involve silicone-based products that work by hydrating and protecting the skin. However, CBD oil introduces a new active ingredient: cannabidiol, known for its anti-inflammatory and antioxidant properties. Researchers are excited about CBD oil because it may not only aid in reducing scar size but also improve skin texture and color by calming inflammation and promoting skin repair. This dual action could offer a more holistic approach to scar healing compared to traditional methods.

What evidence suggests that CBD oil might be an effective treatment for scar healing?

Research suggests that CBD oil might aid in scar healing. In this trial, one arm will treat half of a vertical forehead scar with CBD oil and a silicone patch. Previous studies have found that CBD improved acne scars by reducing swelling and promoting skin healing. Another review showed that cannabis oil, which contains CBD, can lower harmful molecules during wound healing. In diabetic mice, CBD treatment nearly doubled the levels of a protein crucial for tissue repair. These findings suggest that CBD oil could help scars heal by reducing damage and aiding skin repair. ^{1 4 6 7 8}

Who Is on the Research Team?

Mark Mims, M.D., Ph.D.

Principal Investigator

University of Oklahoma

Are You a Good Fit for This Trial?

Adults of any gender or ethnicity who have had a Paramedian forehead flap (PMFF) surgery are eligible for this study. It's not suitable for anyone under 18 or those with allergies to CBD.

Exclusion Criteria

I am under 18 years old.

Patients with known allergies to CBD

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive either a silicone patch or a combination of CBD oil and a silicone patch on their vertical forehead scar

6 months

Regular postoperative visits

Follow-up

Participants are monitored for safety and effectiveness after treatment, with a blinded rater evaluating scar photographs

6 months

What Are the Treatments Tested in This Trial?

Interventions

• CBD Oil

Trial Overview

The trial is testing if applying CBD oil, known for its anti-inflammatory effects, on forehead scars can improve their appearance. Participants will use a silicone patch combined with flavorless CBD tincture compared to just the silicone patch.

How Is the Trial Designed?

Group I: Split-scar randomized trial arm with CBD oil Experimental Treatment 1 Intervention

The study targets the vertical forehead scar, treating half with CBD oil and a silicone patch (experimental).

Group II: Split-scar randomized trial arm without CBD oil Placebo Group 1 Intervention

The study targets the vertical forehead scar, treating the other scar half with a silicone patch (control).

Who Is Running the Clinical Trial?

University of Oklahoma

Lead Sponsor

Trials

484

Recruited

95,900+

Published Research Related to This Trial

Laser therapy, particularly fractional lasers, plays a crucial role in scar treatment by normalizing both the appearance and structure of scars, enhancing the overall effectiveness of scar rehabilitation.

Combining laser treatments with other methods like surgery and physical therapy leads to significant improvements in scar management while minimizing patient discomfort and complications.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Current trends and future considerations in scar treatment. Waibel, JS., Rudnick, A.[2019]

Citations

1.

clinicaltrials.gov

clinicaltrials.gov/study/NCT06129591

NCT06129591 | Topical CBD Scar Healing Study

Assessment of subjective and objective effects of CBD on the outcomes of healing scars. Proportion of patients who have a positive effect using CBD oil in ...

2.

pmc.ncbi.nlm.nih.gov

pmc.ncbi.nlm.nih.gov/articles/PMC11192675/

Potential of cannabidiol as acne and acne scar treatment

2a). When treated with CBD, both SEB-1 and HaCaT cells exhibited a significant reduction in cellular growth. When subjected to a CBD ...

3.

pmc.ncbi.nlm.nih.gov

pmc.ncbi.nlm.nih.gov/articles/PMC11510192/

Harnessing Cannabis sativa Oil for Enhanced Skin Wound ...

This review article explores the efficacy of cannabis oil in reducing reactive oxygen species (ROS) during the healing of acute and chronic wounds.

4.

sciencedirect.com

sciencedirect.com/science/article/pii/S2211383525006744

Exploring the therapeutic potential of Cannabidiol in soft ...

The results showed that in diabetic mice, CBD treatment nearly doubled the expression of connective tissue growth factor (CTGF), which ...

5.

dermatologytimes.com

dermatologytimes.com/view/study-investigates-cbd-as-acne-and-acne-scar-treatment

Study Investigates CBD as Acne and Acne Scar Treatment

Researchers found that the hemp derivative addressed multiple facets of acne pathophysiology and improved acne scarring overall.

6.

pmc.ncbi.nlm.nih.gov

pmc.ncbi.nlm.nih.gov/articles/PMC9210160/

Topical cannabidiol (CBD) in skin pathology - PubMed Central

Topical cannabis has anti-inflammatory, anti-itching, analgesics, wound healing and anti-proliferative effects on the skin.

7.

pmc.ncbi.nlm.nih.gov

pmc.ncbi.nlm.nih.gov/articles/PMC10895075/

The effect of cannabinoids on wound healing: A review - PMC

Overall, they found no significant reactions via patch testing and only saw a mild phototoxicity at 48 h when treated with hemp seed oil. The ...

8.

link.springer.com

link.springer.com/article/10.1007/s00403-024-03131-9

Potential of cannabidiol as acne and acne scar treatment

These findings emphasize the potential of CBD for the management of acne because of its anti-inflammatory, apoptotic, and lipid-inhibitory effects.