CBD Oil for Scar Healing

Overseen By Mark Mims, M.D., Ph.D.,

Age: 18+

Sex: Any

Trial Phase: Phase 1

Sponsor: University of Oklahoma

Disqualifiers: Under 18, CBD allergy

Compensation: Varies

Number of Visits: Unknown

Duration: 6 months

22 Participants Needed

Trial Summary

Do I need to stop my current medications to join the trial?

The trial information does not specify whether you need to stop taking your current medications.

What data supports the effectiveness of the treatment CBD Oil for scar healing?

While there is no direct evidence from the provided research articles about CBD Oil's effectiveness for scar healing, evidence from case studies on similar natural oils like pracaxi and copaiba oil suggests they can be effective in scar management. This implies that CBD Oil might also have potential benefits for scar healing. ^{1 2 3 4 5}

Is CBD oil generally safe for humans?

CBD oil is generally considered safe for humans, but it can cause side effects like vomiting, diarrhea, fever, sleepiness, and abnormal liver function. These side effects are usually mild, but it's important to be aware of them and discuss any concerns with a healthcare provider. ^{2 6 7 8 9}

How does CBD oil differ from other treatments for scar healing?

CBD oil is unique for scar healing because it activates the cannabinoid 2 (CB2) receptor, which helps reduce inflammation and scar formation while promoting skin cell growth and wound closure. This mechanism is different from traditional treatments that may not target these specific pathways. ^{6 10 11 12 13}

What is the purpose of this trial?

CBD has anti-inflammatory properties, and it interacts with skin receptors that help keep the skin healthy. This is why, investigators are looking into using CBD oil on forehead scars to see if it makes scars look better.

Eligibility Criteria

Adults of any gender or ethnicity who have had a Paramedian forehead flap (PMFF) surgery are eligible for this study. It's not suitable for anyone under 18 or those with allergies to CBD.

Exclusion Criteria

I am under 18 years old.

Patients with known allergies to CBD

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive either a silicone patch or a combination of CBD oil and a silicone patch on their vertical forehead scar

6 months

Regular postoperative visits

Follow-up

Participants are monitored for safety and effectiveness after treatment, with a blinded rater evaluating scar photographs

6 months

Treatment Details

Interventions

• CBD Oil

Trial Overview The trial is testing if applying CBD oil, known for its anti-inflammatory effects, on forehead scars can improve their appearance. Participants will use a silicone patch combined with flavorless CBD tincture compared to just the silicone patch.

Participant Groups

Group I: Split-scar randomized trial arm with CBD oil Experimental Treatment 1 Intervention

The study targets the vertical forehead scar, treating half with CBD oil and a silicone patch (experimental).

Group II: Split-scar randomized trial arm without CBD oil Placebo Group 1 Intervention

The study targets the vertical forehead scar, treating half with a silicone patch (control).

Who Is Running the Clinical Trial?

University of Oklahoma

Lead Sponsor

Trials

484

Recruited

95,900+

Findings from Research

Laser therapy, particularly fractional lasers, plays a crucial role in scar treatment by normalizing both the appearance and structure of scars, enhancing the overall effectiveness of scar rehabilitation.

Combining laser treatments with other methods like surgery and physical therapy leads to significant improvements in scar management while minimizing patient discomfort and complications.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Current trends and future considerations in scar treatment. Waibel, JS., Rudnick, A.[2019]

References

1. United States pubmed.ncbi.nlm.nih.gov

The patient-reported impact of scars measure: development and validation. [2022]

2. United States pubmed.ncbi.nlm.nih.gov

Compounding with Pracaxi Versus Copaiba Oil. [2022]

3. United States pubmed.ncbi.nlm.nih.gov

Glucocorticosteroid and Silicone Gel During Patch Application Without Clinical Scar Improvement After Central Venous Catheter Removal: A Randomized Trial. [2022]

4. United States pubmed.ncbi.nlm.nih.gov

Pharmaceutical Prophylaxis of Scarring with Emphasis on Burns: A Review of Preclinical and Clinical Studies. [2023]

5. United States pubmed.ncbi.nlm.nih.gov

Current trends and future considerations in scar treatment. [2019]

6. England pubmed.ncbi.nlm.nih.gov

Probable cutaneous adverse drug reaction due to a cannabidiol-containing hemp oil product in a dog. [2022]

7. England pubmed.ncbi.nlm.nih.gov

Abnormal cannabidiol attenuates experimental colitis in mice, promotes wound healing and inhibits neutrophil recruitment. [2020]

8. Netherlands pubmed.ncbi.nlm.nih.gov

[Use of cannabidiol oil in children]. [2020]

9. United States pubmed.ncbi.nlm.nih.gov

Systematic Review on Transdermal/Topical Cannabidiol Trials: A Reconsidered Way Forward. [2023]

10. Netherlands pubmed.ncbi.nlm.nih.gov

Pharmacological activation of cannabinoid 2 receptor attenuates inflammation, fibrogenesis, and promotes re-epithelialization during skin wound healing. [2022]

11. England pubmed.ncbi.nlm.nih.gov

Role of marijuana components on the regenerative ability of stem cells. [2021]

12. Switzerland pubmed.ncbi.nlm.nih.gov

Abnormal Cannabidiol Affects Production of Pro-Inflammatory Mediators and Astrocyte Wound Closure in Primary Astrocytic-Microglial Cocultures. [2023]

13. Italy pubmed.ncbi.nlm.nih.gov

A therapeutic effect of cbd-enriched ointment in inflammatory skin diseases and cutaneous scars. [2019]