Bariatric Surgery vs Diet for Weight Loss

Recruiting in Palo Alto (17 mi)

Overseen ByAndres Acosta

Age: 18+

Sex: Any

Travel: May be covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Mayo Clinic

No Placebo Group

Trial Summary

What is the purpose of this trial?It is unknown whether the bile acid pathway reacts differently to weight loss resulting from Roux-En-Y Gastric Bypass (RYGB) surgery than weight loss resulting from caloric restriction alone.

Eligibility Criteria

This trial is for adults with severe obesity (BMI ≥ 40) who are healthy or have controlled health issues. Women must not be pregnant. Participants will either undergo Roux-En-Y Gastric Bypass surgery at the Mayo Clinic or follow a low-calorie diet if they're not having surgery. People with untreated psychiatric disorders, alcoholism, eating disorders, certain past surgeries, chronic gastrointestinal diseases, or conditions affecting study participation are excluded.

Participant Groups

The study compares how the bile acid pathway responds to weight loss from two methods: Roux-En-Y Gastric Bypass surgery and a strict low-calorie diet alone. The goal is to see if there's a difference in this metabolic pathway depending on the weight loss strategy used.

2Treatment groups

Active Control

Group I: Roux-En-Y Gastric Bypass (RYGB)Active Control1 Intervention

Participants will have elected to have RYGB surgery per standard of care.

Group II: Low-calorie DietActive Control1 Intervention

Participants will have a low-calorie diet prescribed by a registered dietitian.