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Behavioral Intervention

Mindfulness-Based Therapy for Depression (MAT Process Trial)

N/A
Recruiting
Led By Morganne Kraines, PhD
Research Sponsored by Butler Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 10-week
Awards & highlights

MAT Process Trial Summary

This trial aims to investigate whether Mindfulness-Based Cognitive Therapy or Wellness for Wellbeing can affect emotions by testing their effect on inhibition, updating & shifting. Participants will take surveys, interviews & computer tasks.

Who is the study for?
This trial is for English-speaking adults (18+) with mild to moderate depression, who have had a major depressive episode in the last 5 years but are not currently experiencing severe symptoms or a major episode. Participants should not be undergoing recent changes in psychotherapy or medication, and must not have prior mindfulness-based treatment experience.Check my eligibility
What is being tested?
The study compares Mindfulness-Based Cognitive Therapy (MBCT) with Wellness for Wellbeing to see how they affect mood and thought processes related to emotions. It uses random assignment to either intervention and measures outcomes through tasks that assess emotional control like inhibition, updating, and shifting.See study design
What are the potential side effects?
Since this trial involves psychological therapies rather than medications, side effects may include temporary increases in emotional discomfort as participants engage with their thoughts and feelings during therapy sessions.

MAT Process Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~10-week
This trial's timeline: 3 weeks for screening, Varies for treatment, and 10-week for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Affective Go/No-Go
Affective Internal Switching Task
Depression Symptoms
+1 more
Secondary outcome measures
Attention Control Scale
Five Factor Mindfulness Scale
Generalized Anxiety Disorder -7
+3 more

MAT Process Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Mindfulness-Based Cognitive Therapy (MBCT)Experimental Treatment1 Intervention
MBCT classes are comprised of weekly, 2.5-hour classes in which participants learn cognitive therapy techniques and practice meditation exercises. Participants will complete group and/or individual orientation to MBCT with the MBCT instructor, 1-2 weeks prior to the first scheduled MBCT class. Additionally, MBCT requires 45-minutes of daily home practice, and a full day, 8-hour silent meditation retreat. MBCT classes are delivered via the protocol and curriculum developed by the MBCT founders. Participants randomized to MBCT will receive 8-weeks of MBCT classes.
Group II: Wellness for WellbeingActive Control1 Intervention
Wellness for Wellbeing will serve as the active control for MBCT. Participants randomized to Wellness for Wellbeing will receive 1-hour group delivered classes, once per week, for 8-weeks. Participants will receive an orientation to Wellness for Wellbeing 1-2 weeks prior to the first class. Classes will be delivered by a research therapist. Topics for Wellness for Wellbeing include: nutrition, caffeine, preventing cancer, diabetes, heart health, sleep, being a smart patient, and complementary and alternative medicine. Wellness for Wellbeing classes are interactive and do not include components designed to impact affective cognition in any way. Because participants may have varying levels of health literacy, the research therapist tailors presentation of the material to the participants' level of knowledge of the topic. Information presented in Wellness for Wellbeing is regularly updated with current health guidelines.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Mindfulness-Based Cognitive Therapy
2013
Completed Phase 2
~5470

Find a Location

Who is running the clinical trial?

Butler HospitalLead Sponsor
129 Previous Clinical Trials
16,342 Total Patients Enrolled
31 Trials studying Depression
6,313 Patients Enrolled for Depression
National Center for Complementary and Integrative Health (NCCIH)NIH
832 Previous Clinical Trials
668,857 Total Patients Enrolled
61 Trials studying Depression
32,834 Patients Enrolled for Depression
Morganne Kraines, PhDPrincipal InvestigatorButler Hospital

Media Library

Mindfulness-Based Cognitive Therapy (Behavioral Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT05585775 — N/A
Depression Research Study Groups: Wellness for Wellbeing, Mindfulness-Based Cognitive Therapy (MBCT)
Depression Clinical Trial 2023: Mindfulness-Based Cognitive Therapy Highlights & Side Effects. Trial Name: NCT05585775 — N/A
Mindfulness-Based Cognitive Therapy (Behavioral Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05585775 — N/A
Depression Patient Testimony for trial: Trial Name: NCT05585775 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the purpose of this research endeavor?

"The primary endpoint of this 10-week long clinical trial is Emotional n-back, with secondary objectives including the Generalized Anxiety Disorder - 7 self-report measure of anxiety symptoms, Five Factor Mindfulness Scale's self-reported assessment of mindfulness, and Patient Health Questionnaire - 9 as an indicator for depression."

Answered by AI

What is the total capacity for participants of this clinical trial?

"Affirmative. Per the clinicaltrials.gov listing, this research endeavour is presently seeking volunteers to participate in it; first posted on January 1st 2023 and recently updated on November 22nd 2022. 76 people are needed from a single clinic for enrolment into the trial."

Answered by AI

Are there any available positions in this research project right now?

"Affirmative. Clinicaltrials.gov outlines that this clinical trial, which was initially posted on January 1st 2023, is actively searching for participants. A total of 76 patients must be recruited from a single medical centre."

Answered by AI

Who else is applying?

What state do they live in?
New York
Connecticut
California
Other
What portion of applicants met pre-screening criteria?
Met criteria
Did not meet criteria
How many prior treatments have patients received?
1
2
0
3+
What site did they apply to?
Butler Hospital

Why did patients apply to this trial?

I've tried other meds and they don't work. Because I don’t want to be depressed anymore.
PatientReceived 2+ prior treatments
I would like to try other medications for my MDD. I've tried three other drug treatments that didn't work.
PatientReceived 2+ prior treatments
still looking for a more complete depression resolution.
PatientReceived no prior treatments

What questions have other patients asked about this trial?

When will it begin and is it a paid study? How many visits? Is this study a compensated study? Consider video visits?
PatientReceived 2+ prior treatments
I would like to know about compensation, and whether it's in or out patient, and if you can provide transportation?
PatientReceived 2+ prior treatments

How responsive is this trial?

Typically responds via
Phone Call
Most responsive sites:
  1. Butler Hospital: < 24 hours
Average response time
  • < 2 Days
Recent research and studies
clinicaltrials.govStudy
Mood and Thought Process Study
Morganne Kraines 2023. "Mood and Thought Process Study". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05585775.
All > Depression Boston
~51 spots leftby Dec 2026
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