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Gamete Treatment for Infertility

N/A
Recruiting
Led By Gianpiero Palermo, MD, PhD
Research Sponsored by Weill Medical College of Cornell University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Patients with complete fertilization failure with standard IVF or failure with one prior ICSI treatment cycle
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 months
Awards & highlights
No Placebo-Only Group

Study Summary

This trial will test whether a new fertility treatment, which involves treating eggs and sperm with a special solution, is effective.

Who is the study for?
This trial is for individuals who have experienced complete fertilization failure with standard IVF or those who have had one unsuccessful ICSI treatment cycle. It's not open to people who don't meet these specific conditions, or those who have only tried IVF without ICSI.Check my eligibility
What is being tested?
The study is examining the effectiveness of a special gamete treatment on egg and sperm. The goal is to see if this can improve fertilization rates and support embryo development before and after implantation in patients facing infertility issues.See study design
What are the potential side effects?
Since the trial involves gamete treatment rather than drug administration, traditional side effects are not applicable. However, there may be risks associated with the procedures used to handle eggs and sperm which will be discussed by healthcare providers.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I've had unsuccessful standard IVF or one failed ICSI cycle.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Fertilization rate

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: gamete treatment- oocytes and spermExperimental Treatment1 Intervention
The spermatozoa will be prepared in the standard fashion and utilized for injection after exposure to a membrane permeabilizing agent. Patient specimen will be selected through a synthetic, sterile, single-use, culture-tested mesh. The specimen will then be placed in a 37°C environment. After 30 minutes, the selected portion is retrieved from the other side of the mesh. The injected oocytes will be then exposed to the previously mentioned activating agents for the purpose of inducing embryo development. The successfully fertilized oocytes will be further kept in culture for up to 5 days as per standard IVF/ICSI.

Find a Location

Who is running the clinical trial?

Weill Medical College of Cornell UniversityLead Sponsor
1,047 Previous Clinical Trials
1,327,206 Total Patients Enrolled
24 Trials studying Infertility
7,433 Patients Enrolled for Infertility
Gianpiero Palermo, MD, PhDPrincipal InvestigatorWeill Medical College of Cornell University
1 Previous Clinical Trials
2,000 Total Patients Enrolled
1 Trials studying Infertility
2,000 Patients Enrolled for Infertility

Media Library

Gamete Treatment (Other) Clinical Trial Eligibility Overview. Trial Name: NCT01944332 — N/A
Infertility Research Study Groups: gamete treatment- oocytes and sperm
Infertility Clinical Trial 2023: Gamete Treatment Highlights & Side Effects. Trial Name: NCT01944332 — N/A
Gamete Treatment (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT01944332 — N/A
Infertility Patient Testimony for trial: Trial Name: NCT01944332 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the eligibility criteria for participation in this research?

"The 1200 participants of this infertility clinical trial must be aged between 21 and 89. Candidates should meet the criterion of complete fertilization failure with standard IVF or one prior failed ICSI treatment cycle."

Answered by AI

What is the maximum number of participants being enrolled in this clinical trial?

"Affirmative. The details on clinicaltrials.gov indicate that the trial is actively recruiting patients, which began when it was posted in September 2007 and amended most recently in March 2022. This study requires 1200 participants from a single medical site."

Answered by AI

Are any new participants currently being admitted to this research?

"Affirmative. According to the clinicaltrials.gov registry, this trial is presently recruiting participants, with a public launch date of September 1st 2007 and 1200 patients needed from one medical centre. The study was most recently updated on March 26th 2022."

Answered by AI

Are aged individuals over seventy-five years being included in the experiment?

"This medical experiment is enrolling individuals whose age lies between 21 and 89 years."

Answered by AI

Who else is applying?

What state do they live in?
California
North Carolina
New York
Other
How old are they?
18 - 65
What site did they apply to?
Center fo Reproductive Medicine
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
3+
0

Why did patients apply to this trial?

To get pregnant and give birth safely. I am still wonder why all my failures ?
PatientReceived 1 prior treatment
I’ve tried Chlomid, 3 cycles and still not pregnant. Why? To get pregnant and help others to get pregnant, too.
PatientReceived 1 prior treatment
I don't have any children. I hope this trial will be helpful.
PatientReceived 2+ prior treatments

What questions have other patients asked about this trial?

How expensive is trial? And what the success rate to get pregnant? Will you use PRP? Will you have an holistic approach? Which are the financial implications? do you accept foreigners?
PatientReceived 2+ prior treatments

How responsive is this trial?

Typically responds via
Email
Most responsive sites:
  1. Center fo Reproductive Medicine: < 24 hours
Average response time
  • < 2 Days
~90 spots leftby Jun 2025