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Gamete Treatment for Infertility

N/A
Recruiting
Led By Gianpiero Palermo, MD, MPH
Research Sponsored by Weill Medical College of Cornell University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Patients with complete fertilization failure with standard IVF or failure with one prior ICSI treatment cycle
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 months
Awards & highlights

Summary

This trial will test whether a new fertility treatment, which involves treating eggs and sperm with a special solution, is effective.

Who is the study for?
This trial is for individuals who have experienced complete fertilization failure with standard IVF or those who have had one unsuccessful ICSI treatment cycle. It's not open to people who don't meet these specific conditions, or those who have only tried IVF without ICSI.Check my eligibility
What is being tested?
The study is examining the effectiveness of a special gamete treatment on egg and sperm. The goal is to see if this can improve fertilization rates and support embryo development before and after implantation in patients facing infertility issues.See study design
What are the potential side effects?
Since the trial involves gamete treatment rather than drug administration, traditional side effects are not applicable. However, there may be risks associated with the procedures used to handle eggs and sperm which will be discussed by healthcare providers.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I've had unsuccessful standard IVF or one failed ICSI cycle.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Fertilization rate

Trial Design

1Treatment groups
Experimental Treatment
Group I: gamete treatment- oocytes and spermExperimental Treatment1 Intervention
The spermatozoa will be prepared in the standard fashion and utilized for injection after exposure to a membrane permeabilizing agent. Patient specimen will be selected through a synthetic, sterile, single-use, culture-tested mesh. The specimen will then be placed in a 37°C environment. After 30 minutes, the selected portion is retrieved from the other side of the mesh. The injected oocytes will be then exposed to the previously mentioned activating agents for the purpose of inducing embryo development. The successfully fertilized oocytes will be further kept in culture for up to 5 days as per standard IVF/ICSI.

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Who is running the clinical trial?

Weill Medical College of Cornell UniversityLead Sponsor
1,064 Previous Clinical Trials
1,317,986 Total Patients Enrolled
24 Trials studying Infertility
7,433 Patients Enrolled for Infertility
Gianpiero Palermo, MD, MPHPrincipal InvestigatorWeill Medical College of Cornell University
Gianpiero Palermo, MD, PhDPrincipal InvestigatorWeill Medical College of Cornell University
1 Previous Clinical Trials
2,000 Total Patients Enrolled
1 Trials studying Infertility
2,000 Patients Enrolled for Infertility

Media Library

Gamete Treatment (Other) Clinical Trial Eligibility Overview. Trial Name: NCT01944332 — N/A
Infertility Research Study Groups: gamete treatment- oocytes and sperm
Infertility Clinical Trial 2023: Gamete Treatment Highlights & Side Effects. Trial Name: NCT01944332 — N/A
Gamete Treatment (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT01944332 — N/A
Infertility Patient Testimony for trial: Trial Name: NCT01944332 — N/A
~62 spots leftby Jun 2025
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