AHCC Capsules for Head and Neck Cancer
Trial Summary
Do I need to stop taking my current medications to join the trial?
The trial does not specify if you need to stop taking your current medications, but you cannot be on immunosuppressive medication within 7 days before joining, except for certain low-dose steroids and specific premedications.
How is the AHCC treatment different from other treatments for head and neck cancer?
AHCC (Active Hexose Correlated Compound) is unique because it is a natural supplement derived from mushrooms, which may support the immune system, unlike traditional chemotherapy drugs that directly target cancer cells. This makes it a novel approach as it potentially enhances the body's natural defenses rather than directly attacking the cancer.12345
What is the purpose of this trial?
This is a phase 2, single-arm, open-label clinical trial determining safety and tolerability of AHCC in subjects with HPV-positive patients with Head and Neck Squamous Cell Carcinoma. These are subjects who have undergone surgery or will be undergoing surgery.
Research Team
Rupali Nabar
Principal Investigator
Chao Family Comprehensive Cancer Center
Eligibility Criteria
Adults aged 18-79 with HPV-positive Head and Neck Squamous Cell Carcinoma (HNSCC) who've had or will have surgery. They must be at high risk for disease recurrence, not pregnant, willing to use contraception, and free from serious infections, autoimmune diseases treated within the last 2 years, organ transplants, certain heart conditions, HIV with detectable viral load or history of specific diseases.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive AHCC in combination with standard of care treatment for HPV-positive Head and Neck Squamous Cell Carcinoma
Follow-up
Participants are monitored for safety, tolerability, and changes in HPV DNA as a marker of tumor response or recurrence
Treatment Details
Interventions
- AHCC
AHCC is already approved in Japan, United States for the following indications:
- General health maintenance
- Immune support
- Complementary therapy for cancer patients
- Dietary supplement for immune support
- Complementary therapy for cancer patients
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, Irvine
Lead Sponsor