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Intraoperative Brain Microdialysis for Epilepsy

N/A

Waitlist Available

Led By Charles Howe, PhD

Research Sponsored by Mayo Clinic

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Failure to respond to at least two trials of anti-seizure drugs with different mechanisms of action

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up through study completion, up to 5 years

Awards & highlights

Study Summary

This trial will look at brain fluid from people with epilepsy who are having surgery. They hope to find new ways to control seizures for people who don't respond to drugs.

Who is the study for?

This trial is for individuals with epilepsy who haven't improved after trying at least two different anti-seizure medications. They should have a normal MRI scan and not be on immune-modifying treatments, have autoimmune disorders, infections, or cancer-related health issues.Check my eligibility

What is being tested?

The study involves collecting and analyzing fluid from the brain during epilepsy surgery to look for inflammation markers. This could lead to new seizure control methods for drug-resistant epilepsy in the future.See study design

What are the potential side effects?

Since this trial involves standard surgical procedures without additional drugs being tested, side effects are primarily those associated with typical risks of brain surgery.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I have tried at least two different seizure medications without success.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ through study completion, up to 5 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~through study completion, up to 5 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion, up to 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Detection of analytes/protein

Trial Design

1Treatment groups

Experimental Treatment

Group I: drug-resistant temporal lobe epilepsyExperimental Treatment1 Intervention

Our current standard practice is to use a lateral approach through the middle temporal gyrus to place 3 depth electrodes targeting the hippocampus for intraoperative verification of pathological epileptiform activity prior to resection. Our research protocol will add one FDA approved electrode that has a central cannula for insertion of a microdialysis probe. The electro-physiological data that will be gathered is not altered and this methodology will not impact standard clinical care, except and will not to extend the duration in the OR - the measurements will occur during the clinical electrocorticography (ECoG; intracranial electroencephalography (iEEG)) procedure by 15 min.

0 / 1Eligibility criteria met

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Who is running the clinical trial?

Mayo ClinicLead Sponsor

3,207 Previous Clinical Trials

3,767,137 Total Patients Enrolled

22 Trials studying Epilepsy

1,189 Patients Enrolled for Epilepsy

Charles Howe, PhDPrincipal InvestigatorMayo Clinic

Media Library

Intraoperative Brain Microdialysis (Other) Clinical Trial Eligibility Overview. Trial Name: NCT04531722 — N/A

Epilepsy Research Study Groups: drug-resistant temporal lobe epilepsy

Epilepsy Clinical Trial 2023: Intraoperative Brain Microdialysis Highlights & Side Effects. Trial Name: NCT04531722 — N/A

Intraoperative Brain Microdialysis (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04531722 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is enrollment for this medical experiment open at the moment?

"Regrettably, per clinicaltrials.gov this trial is not presently recruiting patients for participation; the study was originally posted on March 27th 2019 and last updated October 3rd 2022. However, there are 239 other trials that require volunteers at present."

Answered by AI

Is my profile suitable for being involved in this investigation?

"To partake in this clinical trial, patients must present with aura and be aged between 18 to 45. There are a total of 3 spots available for enrolment."

Answered by AI