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Speech-Language Therapy for Primary Progressive Aphasia
N/A
Recruiting
Led By Stephanie M Grasso, Ph.D
Research Sponsored by University of Texas at Austin
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Meets diagnostic criteria for Primary Progressive Aphasia (PPA; Gorno-Tempini et al., 2011)
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up pre-phase 1, post-phase1/pre-phase 2 (4.5 weeks from treatment onset), post-phase 2 (9 weeks from treatment onset), 6 months and 1 year post-treatment
Awards & highlights
Study Summary
This trial seeks to study how tailored speech-language interventions help bilingual individuals with PPA. Researchers will evaluate effects of treatment, language use, and brain scans to determine best approach.
Who is the study for?
This trial is for bilingual individuals who speak Spanish and Catalan or Spanish and English, diagnosed with Primary Progressive Aphasia (PPA). Participants must have a certain level of cognitive function as measured by the Mini-Mental State Examination. Those with other central nervous system issues, significant sensory impairments, or prominent non-speech-language impairments cannot join.Check my eligibility
What is being tested?
The study tests two speech-language interventions: Video-Implemented Script Training for Aphasia (VISTA) and Lexical Retrieval Training (LRT), tailored for bilingual speakers with PPA. It aims to understand how bilingualism affects treatment response in PPA over time, including follow-ups at 6 and 12 months post-treatment.See study design
What are the potential side effects?
Since this trial involves speech-language therapy rather than medication, traditional side effects are not expected. However, participants may experience fatigue or frustration during the intervention sessions.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I have been diagnosed with Primary Progressive Aphasia.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ pre-phase 1, post-phase1/pre-phase 2 (4.5 weeks from treatment onset), post-phase 2 (9 weeks from treatment onset), 6 months and 1 year post-treatment
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~pre-phase 1, post-phase1/pre-phase 2 (4.5 weeks from treatment onset), post-phase 2 (9 weeks from treatment onset), 6 months and 1 year post-treatment
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Percent correct intelligible words from trained/untrained scripts
Percent correct spoken naming of trained/untrained nouns
Secondary outcome measures
Acoustic Features: Articulation Rate
Acoustic Features: Speech-to-pause time
Aphasia Impact Questionnaire (AIQ)
+2 moreOther outcome measures
Post-treatment Communication Survey
Trial Design
2Treatment groups
Experimental Treatment
Group I: Video Implemented Script Training for AphasiaExperimental Treatment2 Interventions
Script training intervention for individuals with nonfluent/agrammatic PPA.
Group II: Lexical Retrieval TrainingExperimental Treatment2 Interventions
Naming intervention for individuals with logopenic or semantic variant PPA.
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Who is running the clinical trial?
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant PauOTHER
339 Previous Clinical Trials
161,857 Total Patients Enrolled
Hospital Clinic of BarcelonaOTHER
409 Previous Clinical Trials
5,401,386 Total Patients Enrolled
University of Texas at AustinLead Sponsor
353 Previous Clinical Trials
81,184 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I have been diagnosed with Primary Progressive Aphasia.You score 15 or more on the Mini-Mental State Examination.I have a psychiatric condition that causes symptoms.I have a condition that affects my brain or nerves.You have a low score on a test that measures memory and thinking skills.I have experience in multiple languages, regardless of my proficiency level.You have noticeable problems with thinking, behavior, or movement, other than speaking.
Research Study Groups:
This trial has the following groups:- Group 1: Video Implemented Script Training for Aphasia
- Group 2: Lexical Retrieval Training
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is this research endeavor actively seeking participants at present?
"Unfortunately, the trial's update on clinicaltrials.gov suggests that it is no longer actively recruiting patients. The initial posting was made on February 27th 2023 and edited two weeks later; however, 1843 other trials are still seeking participants at this time."
Answered by AI
What are the main objectives of this clinical trial?
"This study's primary outcome, measured over Pre-phase 1, post-phase1/pre-phase 2 (4.5 weeks from treatment onset), post-phase 2 (9 weeks from treatment onset), 6 months and 1 year post-treatment is a comparison of the percentage of correctly spoken naming of trained/untrained nouns. Secondary measures include Type-token ratio which reflects the number of unique words divided by total word count derived from connected speech samples; Mean length of utterance calculating average words produced per utterance taken from script topic probes, picture description, or personal narrative; and Articulation Rate using syllables per second"
Answered by AI
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