Experimental Clinical Trials
Experimental studies recruiting patients for novel treatments. Filter by phase, distance, and inclusion criteria to find your perfect experimental clinical trial.
Condition
Experimental
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Clinical Trials
Experimental Clinical Trials
Phase-Based Estimates
1
Effectiveness
2
Safety
Ceftriaxone
for Gonorrhea Male
Chapel Hill, NC
18 - 65
Male
Phase 2
Recruiting
Chapel Hill, NC
18 - 65
Male
This is a double-blind randomized controlled trial to test whether the group B meningitis vaccine 4 component Neisseria meningitidis serogroup B vaccine (BEXSEROTM) (4C-MenB), trade name Bexsero™), currently approved for use by the United States Food and Drug Administration (FDA) and recommended by the Centers for Disease Control and Prevention (CDC) for protection from Neisseria meningitidis infections, also protects from Neisseria gonorrhoeae infection using controlled human experimental infection to test protection. The information the investigator learn by doing this study may also help to develop a vaccine that protects individuals from having gonorrhea infection. The study population will consist of male participants > 18 and < 36 years old, living in central North Carolina, in general good health without a history of 4C-MenB vaccination. Approximately 120-140 participants will be enrolled. Participants will receive 2 doses of vaccine (2 doses of 4C-MenB or 2 comparator vaccines- seasonal influenza and tetanus/diptheria booster) as intramuscular injections, and then one intraurethral challenge with Neisseria gonorrhoeae. Following the challenge, participants will cross-over and receive two doses of vaccines not received prior to challenge (2 doses of 4CMenB or the 2 comparator vaccines- seasonal influenza and tetanus/diptheria booster) All participants receive all vaccinations by the end of the study and all vaccines used in this study are licensed and FDA-approved.
Phase-Based Estimates
1
Effectiveness
1
Safety
Bacteriophage
for Shigellosis
Baltimore, MD
18 - 65
All Sexes
Phase 1 & 2
Waitlist Available
Baltimore, MD
18 - 65
All Sexes
The study is a first-in-human Phase 1/2a randomized, double-blind, placebo-controlled trial to assess the clinical safety and efficacy of ShigActive in healthy adults with experimental Shigella challenge.
Phase-Based Estimates
1
Effectiveness
1
Safety
Semi-autonomous Myoelectric Control Algorithm
for Amputation, Traumatic
Boulder, CO
18+
All Sexes
Waitlist Available
Boulder, CO
18+
All Sexes
This study is evaluating whether a semi-autonomous control algorithm can be developed to control a prosthetic hand.
Phase-Based Estimates
1
Effectiveness
1
Safety
VRC-MALMAB0114-00-AB
for Malaria
Bethesda, MD
18 - 65
All Sexes
Phase 1
Waitlist Available
Locally Advanced
Bethesda, MD
18 - 65
All Sexes
This study is evaluating whether a drug can prevent malaria infection in people.
Phase-Based Estimates
1
Effectiveness
2
Safety
APN01
for COVID-19
Houston, TX
18+
All Sexes
Phase 2 & 3
Recruiting
Houston, TX
18+
All Sexes
This study is evaluating whether a treatment that modulates the host tissue response can improve clinical outcomes in patients with COVID-19.
Phase-Based Estimates
1
Effectiveness
1
Safety
Menthol And Tobacco E-liquids
for Smoking, Cigarette
Winston-Salem, NC
18+
All Sexes
Recruiting
Winston-Salem, NC
18+
All Sexes
Menthol cigarettes comprise almost one-third of the United States (US) market share and are disproportionately smoked by racial minorities. Tobacco control policies targeting menthol flavoring in tobacco could have significant public health outcomes, especially among black smokers. One key challenge of tobacco regulation is weighing the risks and benefits of potential policies across different populations (i.e., users and non-users). Tension arises between policies intended to prevent adolescent and young adult (AYA) tobacco initiation and those intended to reduce harm among current tobacco users. The availability of menthol e-liquids may be important for encouraging menthol cigarette smokers to switch to e- cigarettes, but mint e-liquids, which are appealing to AYA, may be unnecessary to facilitate switching. Including mint e-liquids in flavor bans but allowing menthol e-liquids to remain on the market as potential substitution products for menthol smokers may be an optimal policy approach. The study team is proposing a lab study and field assessment to determine how including menthol and mint e-liquids in e-liquid flavor bans or sales restrictions affects tobacco product purchasing and use among menthol cigarette smokers. At lab sessions, participants will complete the Experimental Tobacco Marketplace (ETM) task, a behavioral economics task in which they receive account balances to an online store and can buy menthol cigarettes at escalating costs or buy e-liquids, non-menthol cigarettes, or nicotine replacement gum at fixed costs. They will complete the task under four marketplace conditions: (1) only tobacco e-liquids available, (2) menthol and tobacco e-liquids available, (3) menthol, mint, and tobacco e-liquids available, and (4) tobacco, menthol, mint, fruit, dessert. During a field assessment, product choice is validated by assessing use of products purchased during the ETM task. This proposal will inform policy-makers about the impact banning menthol and mint e-liquids will have on facilitating menthol cigarette smokers switching to e-cigarettes.
Phase-Based Estimates
1
Effectiveness
1
Safety
Increase Morning Bright Light
for Shift-Work Sleep Disorder
Pittsburgh, PA
< 18
All Sexes
Recruiting
High Risk
Pittsburgh, PA
< 18
All Sexes
This study is evaluating whether a new treatment may help reduce substance use in teenagers.
Phase-Based Estimates
1
Effectiveness
2
Safety
Cannabis
for Allodynia
New York, NY
18 - 65
All Sexes
Phase 2
Recruiting
New York, NY
18 - 65
All Sexes
Chronic pain is a significant public health concern in the U.S., for which prescription opioids have historically been the standard treatment. This has resulted in striking rates of opioid use disorders and fatal overdoses. Identifying non-opioid medications for the management of chronic pain with minimal abuse liability is a public health necessity, and cannabinoids are a promising drug class for this purpose. More than 80% of medicinal cannabis users report pain as their primary medical indication, and they report experiencing minimal psychoactive effects. However, there are few well-controlled human laboratory studies assessing cannabis' efficacy for pain in the context of abuse, and even less is known regarding the effects of daily repeated use of cannabis on pain and its relationship to abuse liability. Carefully controlled research is needed. The proposed randomized, within-subjects, placebo-controlled 16-day crossover inpatient human laboratory study (N = 20 healthy cannabis users; 10 men, 10 women) will address three important gaps in our understanding of the potential therapeutic utility of cannabis for pain: 1) Does tolerance develop to repeated, daily smoked cannabis administration on measures of experimental pain and abuse liability; 2) If so, is tolerance reversed during the 7 days of abstinence from active-THC cannabis; 3) Does abrupt abstinence from active cannabis increase experimental pain sensitivity, i.e. hyperalgesia, relative to baseline, and do these effects parallel measures of cannabis withdrawal such as disrupted mood and sleep? Two distinct modalities of experimental pain will be assessed: The Cold Pressor Test (CPT) and Quantitative Sensory Testing Thermal Temporal Summation (QST-TTS). Throughout the study, experimental pain and abuse-related effects will be assessed, as will sleep and subjective mood assessments.
Phase-Based Estimates
1
Effectiveness
2
Safety
Cannabis
for Allodynia
New York, NY
18 - 65
All Sexes
Phase 2
Recruiting
New York, NY
18 - 65
All Sexes
Chronic pain is a significant public health concern in the U.S., for which prescription opioids have historically been the standard treatment. This has resulted in striking rates of opioid use disorders and fatal overdoses. Identifying non-opioid medications for the management of chronic pain with minimal abuse liability is a public health necessity, and cannabinoids are a promising drug class for this purpose. More than 80% of medicinal cannabis users report pain as their primary medical indication. These patients tend to seek products that are low in delta-9-tetrahydrocannabinol (THC; the primary psychoactive, and thus intoxicating, component of cannabis), and high in cannabidiol (CBD), a cannabinoid that purportedly has therapeutic benefit for pain but does not produce intoxicating effects [1]. However, there are few well-controlled human laboratory studies assessing the efficacy of high-CBD cannabis for pain in the context of abuse, and even less is known regarding the effects of daily repeated use of cannabis on pain and its relationship to abuse liability. The proposed randomized, within-subjects, placebo-controlled 16-day crossover inpatient human laboratory pilot study (N = 16 healthy cannabis users; 8 men, 8 women) will address important gaps in our understanding of the potential therapeutic utility of cannabis for pain: 1) If repeated cannabis use can result in hyperalgesia; 2) If tolerance to the analgesic and abuse-related effects of cannabis develops and is reversible. Two distinct modalities of experimental pain will be assessed: The Cold Pressor Test (CPT) and Quantitative Sensory Testing Thermal Temporal Summation (QST-TTS), and participants will smoke cannabis 3x/day. Throughout the study, experimental pain and abuse-related effects will be assessed, as will sleep and subjective mood assessments.
Phase-Based Estimates
1
Effectiveness
2
Safety
Sleep Fragmentation
for Sleep Disorders
Baltimore, MD
18 - 65
All Sexes
Phase 2
Recruiting
Baltimore, MD
18 - 65
All Sexes
This study is evaluating whether sleep disturbance patterns alter the way the brain responds to pain medication.
Phase-Based Estimates
1
Effectiveness
1
Safety
Half ROSI-half Sperm Donor Fertilization
for Infertility
Winston-Salem, NC
18+
Male
Recruiting
Winston-Salem, NC
18+
Male
This study is evaluating whether round spermatids can be used to create pregnancy in men with non-obstructive azoospermia.
Phase-Based Estimates
1
Effectiveness
1
Safety
Gallium Ga 68-labeled PSMA-11
for Carcinoma, Renal Cell
Los Angeles, CA
18+
All Sexes
Phase < 1
Recruiting
Metastatic
Los Angeles, CA
18+
All Sexes
This phase I trial studies a new imaging technique called FAPi PET/CT to determine where and to which degree the FAPI tracer (68Ga-FAPi-46) accumulate in normal and cancer tissues in patients with non-prostate cancer. The research team also want to know whether what they see on PET/CT images represents the tumor tissue being excised from the patient's body. The research team is also interested to investigate another new imaging technique called PSMA PET/CT. Participants will be invited to undergo a second PET/CT scan, with the PSMA tracer (68Ga-PSMA-11). This is not required but just an option for volunteer patients. Patients can decide to have only the FAPI PET/CT scan. The PET/CT scanner combines the PET and the CT scanners into a single device. This device combines the anatomic (body structure) information provided by the CT scan with the metabolic information obtained from the PET scan. PET is an established imaging technique that utilizes small amounts of radioactivity attached to very minimal amounts of, in the case of this research, 68Ga-PSMA-11 and 68Ga-FAPi. Because some cancers take up 68Ga-PSMA-11 and/or 68Ga-FAPi it can be seen with PET. CT utilizes x-rays that traverse the body from the outside. CT images provide an exact outline of organs where it occurs in patient's body. FAP stands for Fibroblast Activation Protein. FAP is produced by cells that surround tumors. The function of FAP is not well understood but imaging studies have shown that FAP can be detected with FAPI PET/CT. Imaging FAP with FAPI PET/CT may in the future provide additional information about various cancers. PSMA stands for Prostate Specific Membrane Antigen. This name is incorrect as PSMA is also found in many other cancers. The function of PSMA is not well understood but imaging studies have shown that PSMA can be detected with PET in many non-prostate cancers. Imaging FAP with PET/CT may in the future provide additional information about various cancers.
Phase-Based Estimates
3
Effectiveness
3
Safety
Oral Micronized Progesterone 200mg
for Suicide
Chicago, IL
18 - 65
Female
Phase 4
Recruiting
Chicago, IL
18 - 65
Female
This study is evaluating whether a two-week intervention can help stabilize hormones in females with recent suicidal thoughts.
Phase-Based Estimates
1
Effectiveness
1
Safety
Lower Dose Formulation Of RG SAM (CNE) Vaccine (GSK3903133A)
for Rabies
South Miami, FL
18 - 65
All Sexes
Phase 1
Waitlist Available
Grade I
South Miami, FL
18 - 65
All Sexes
This study is evaluating whether a new rabies vaccine is safe and well tolerated when given to healthy adults.
Phase-Based Estimates
1
Effectiveness
2
Safety
Estradiol 2 Mg Tablet
for Depression, Postpartum
Chapel Hill, NC
18 - 65
Female
Phase 2
Recruiting
Chapel Hill, NC
18 - 65
Female
This study is evaluating whether hormone sensitivity may be related to differences in the brain's response to irritability.
Phase-Based Estimates
1
Effectiveness
1
Safety
Questionnaire Administration
for Smoking, Cigarette
Buffalo, NY
18+
All Sexes
Recruiting
Buffalo, NY
18+
All Sexes
This study is evaluating whether menthol flavored e-cigarettes are more likely to be purchased when menthol cigarettes are available.
Phase-Based Estimates
1
Effectiveness
1
Safety
New Visual Processing Unit (VPU) With Asymmetric Waveforms
for Retinitis
Ann Arbor, MI
18+
All Sexes
Recruiting
Ann Arbor, MI
18+
All Sexes
This study is evaluating whether a new method of retinal stimulation and training may improve the visual ability of retinal prosthesis participants.
Phase-Based Estimates
2
Effectiveness
3
Safety
Fluorouracil
for Adenocarcinoma
Orlando, FL
18+
All Sexes
Phase 3
Waitlist Available
Locally Advanced
Orlando, FL
18+
All Sexes
A study of zolbetuximab (IMAB362) plus mFOLFOX6 versus placebo plus mFOLFOX6 in subjects with Claudin 18.2 positive, HER2-negative, locally advanced unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma. Why is this study being done? SPOTLIGHT is a new clinical study for adult patients who have any of: advanced unresectable gastric or GEJ cancer metastatic gastric or GEJ cancer These types of cancers have a unique set of proteins (called Claudin 18.2). We may be able to use a treatment that targets the proteins to kill the cancer cells. For patients with one of the types of cancer listed above, mFOLFOX6 (a combination of three chemotherapies known as Oxaliplatin, Leucovorin, and Fluorouracil) is a current treatment option. This study is testing an experimental medicine called zolbetuximab (IMAB362). Zolbetuximab attaches itself to Claudin 18.2 on the cancer cells causing cancer cell death. Patients will be assigned to one of two groups by chance and given either: zolbetuximab with mFOLFOX6; or a placebo with mFOLFOX6 A placebo is a treatment that looks like the experimental medicine, but contains no medicine. The goal of the study is to find out if zolbetuximab with mFOLFOX6 helps patients to live longer by stopping the cancer from getting worse.
Phase-Based Estimates
1
Effectiveness
2
Safety
Interferon Gamma-1b
for Mycoses
Boston, MA
Any Age
All Sexes
Phase 2
Waitlist Available
Stage I
Boston, MA
Any Age
All Sexes
This study is evaluating whether a combination of two drugs may be more effective than either drug alone in treating patients with stage IB-IVB mycosis fungoides and Sezary syndrome that has come back (relapsed) or has not responded to previous treatment (refractory).
Phase-Based Estimates
1
Effectiveness
1
Safety
SRX246
for Anxiety
Bethesda, MD
18 - 65
All Sexes
Phase 1
Waitlist Available
Bethesda, MD
18 - 65
All Sexes
To determine the effects of SRX246 on fear and anxiety based on fear-potentiated startle in humans. Additionally, the effects of the compound on emotion recognition will be explored.
Phase-Based Estimates
1
Effectiveness
1
Safety
CC-115
for Prostate Cancer
Seattle, WA
18+
Male
Phase 1
Waitlist Available
Metastatic
Seattle, WA
18+
Male
This study is evaluating whether a combination of enzalutamide and CC-115 is better than enzalutamide alone.
Phase-Based Estimates
1
Effectiveness
1
Safety
Pembrolizumab
for Sarcoma, Kaposi
San Francisco, CA
18+
All Sexes
Phase 1
Recruiting
Grade I
San Francisco, CA
18+
All Sexes
This study is evaluating whether a type of immunotherapy may help treat HIV.
Phase-Based Estimates
1
Effectiveness
1
Safety
Necator Americanus Hookworm Larvae
for Bunostomiasis
Washington, United States
18 - 65
All Sexes
Phase 1
Recruiting
Washington, United States
18 - 65
All Sexes
This study is evaluating whether a hookworm vaccine is safe and can prevent hookworm infection.
Phase-Based Estimates
2
Effectiveness
3
Safety
Experimental Prosthetics Foot (K3 Promoter)
for Amputations
Arvada, CO
18+
All Sexes
Phase 3
Waitlist Available
Arvada, CO
18+
All Sexes
The investigators are currently verifying early data showing that the K3 Promoter prosthetic foot affects walking efficiency or stability in transtibial, unilateral amputees when compared to their current prostheses. Phase II funds are being used to address these metrics. These studies are important basic research, however, while Tensegrity has the unique opportunity to study amputee gait and movement in the CGMA's state-of-the-art facility the investigators will expand these studies with BRDG-SPAN funding by studying the following metrics: Four Square Step Test (FSST) Amputee Mobility Predictor (AMP) Timed Up and Go Test (TUG) Quality of life (QOL) index (SF-36) Activity-specific Balance Confidence Questionnaire (ABC) 3D motion analysis
Phase-Based Estimates
1
Effectiveness
1
Safety
Leadership And Organizational Change For Implementation
for Experimental
La Jolla, CA
18+
All Sexes
Recruiting
La Jolla, CA
18+
All Sexes
This project will test an implementation strategy that seeks to align system, organization, and clinic leadership strategies to implement and sustain the Lyssn artificial intelligence (AI) quality assurance platform to support implementation of Motivational Interviewing (MI) and evidence-based practice (EBP) for substance use disorders. The Leadership and Organizational Change for Implementation - System Level (LOCI-SL) strategy seeks to engage policymakers and funders at the system level to improve implementation leadership, climate, provider attitudes and behaviors at the provider organization level to enhance implementation climate for EBP. LOCI-SL will be tested in a statewide addiction service system through clinics in community based behavioral health organizations.
Phase-Based Estimates
3
Effectiveness
3
Safety
Ethyl Eicosapentaenoic Acid
for Manic Disorder
New York, NY
18 - 65
All Sexes
Phase 4
Recruiting
New York, NY
18 - 65
All Sexes
This study is evaluating whether omega three fatty acids have an antidepressant effect in bipolar depression by decreasing brain inflammation.
Phase-Based Estimates
3
Effectiveness
3
Safety
Influenza Vaccine
for Depression
Austin, TX
18 - 65
All Sexes
Phase 4
Waitlist Available
Austin, TX
18 - 65
All Sexes
This study is evaluating whether the immune system of depressed individuals is different from that of healthy individuals.
Phase-Based Estimates
1
Effectiveness
2
Safety
BMS-986165
for Ileocolitis
Chicago, IL
18+
All Sexes
Phase 2
Recruiting
Chicago, IL
18+
All Sexes
This study is evaluating whether a drug may help treat Crohn's disease.
Phase-Based Estimates
1
Effectiveness
2
Safety
BMS-986205
for Urinary Bladder Cancer
Riverside, CA
18+
All Sexes
Phase 2
Waitlist Available
Riverside, CA
18+
All Sexes
This study is evaluating whether a combination of medications may help treat bladder cancer.
Phase-Based Estimates
1
Effectiveness
1
Safety
Social-Emotional Learning
for Increase School Engagement
Chicago, IL
< 65
All Sexes
Phase 1 & 2
Waitlist Available
Chicago, IL
< 65
All Sexes
Chicago's Department of Family and Support Services will be providing summer employment and social-emotional skill training to youth over the summer of 2012. The investigators are partnering with them to evaluate the effects of the program. The investigators will track applicants to the program through existing administrative databases to assess the short- and long-term effects of the government's program. The investigators hypothesize that the program will decrease violence involvement and criminal activity, increase schooling engagement, and increase future employment outcomes.
Other Trials to Consider
Experimental Formula
for Glycemic Control
Phase-Based Estimates
1
Effectiveness
1
Safety
Recruiting
Miami, FL
18+
All Sexes
Experimental Formula
for Glycemic Control
Phase-Based Estimates
1
Effectiveness
1
Safety
Recruiting
Greenacres City, FL
18+
All Sexes
Experimental
for Breast Cancer
Phase-Based Estimates
1
Effectiveness
1
Safety
Phase 1
Recruiting
Stage I
Rochester, NY
65+
All Sexes
Experimental Denture Adhesive 2
for Denture Retention
Phase-Based Estimates
2
Effectiveness
3
Safety
Phase 3
Recruiting
Indianapolis, IN
18+
All Sexes
Experimental Radiation Dose
for Metastatic Bone Tumor
Phase-Based Estimates
2
Effectiveness
3
Safety
Phase 3
Recruiting
Metastatic
Cincinnati, OH
18+
All Sexes
Core Treatment Active Experimental: SHR0302 Dose#2
for Eczema, Infantile
Phase-Based Estimates
2
Effectiveness
3
Safety
Phase 3
Waitlist Available
Toronto, Canada
Any Age
All Sexes
Experimental: Tezepelumab
for Sinusitis
Phase-Based Estimates
2
Effectiveness
3
Safety
Phase 3
Recruiting
Colorado Springs, CO
18+
All Sexes
Experimental Toddler Drink
for Growth
Phase-Based Estimates
1
Effectiveness
1
Safety
Recruiting
Kingsport, TN
< 18
All Sexes
Experimental
for Coronary Artery Perforation
Phase-Based Estimates
1
Effectiveness
1
Safety
Waitlist Available
Detroit, MI
18+
All Sexes
Experimental
for Violence, Domestic
Phase-Based Estimates
1
Effectiveness
1
Safety
Recruiting
Rapid City, SD
Any Age
All Sexes
Experimental Intervention
for Antineoplastic Agents
Phase-Based Estimates
1
Effectiveness
1
Safety
Waitlist Available
Edmonton, Canada
18+
All Sexes
Telerehabilitation Experimental Group
for Cognitive Decline
Phase-Based Estimates
1
Effectiveness
1
Safety
Recruiting
Stage II
New Brunswick, NJ
18+
Female
Experimental: Interventional Cohort: Treatment Arm
for Hematoma, Subdural, Chronic
Phase-Based Estimates
1
Effectiveness
1
Safety
Recruiting
Morgantown, WV
18+
All Sexes
Experimental (Delphi Surveys)
for Malignancies
Phase-Based Estimates
1
Effectiveness
1
Safety
Recruiting
High Risk
Rochester, NY
65+
All Sexes
Experimental Arm 2
for Cancer
Phase-Based Estimates
1
Effectiveness
1
Safety
Recruiting
Houston, TX
18 - 65
All Sexes
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