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Virotherapy for Castleman Disease
Study Summary
This trial is studying a rare disorder caused by the Kaposi's sarcoma herpes virus (KSHV), which also causes several types of cancer. Researchers want to understand the biology of KSHV-associated multicentric Castleman's disease (MCD) to find ways to treat it.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I am 18 years old or older.I do not have another cancer that needs treatment interfering with this study.I don't have severe health issues unrelated to HIV or my current condition that would stop me from following the study's treatment plan.My condition is confirmed as KSHV-associated MCD by a pathology lab.
- Group 1: Active Treament 3
- Group 2: Active Treatment 1
- Group 3: Active Treatment 2
- Group 4: Active Treatment 4
- Group 5: Active Treatment 5
- Group 6: Natural History
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What medical issues have been addressed through Natural History approaches?
"Natural History is commonly prescribed to Merkel cell cancer patients, but has been found to be effective for the management of a wide array of malignancies including leukemia, ophthalmia, sympathetic and prostate cancers."
Have any previous investigations explored the Natural History of this phenomenon?
"Currently, 1845 clinical studies are being conducted to examine the Natural History phenomenon. Of these trials, 406 have reached Phase 3 and there are 69332 sites that offer this therapy in Bethesda, Maryland alone."
Is the research study currently open to new participants?
"This clinical trial, originally posted on October 28th 2004 and last amended November 19th 2022 is no longer enrolling participants. Nevertheless, there are 4915 other trials that remain open to recruitment."
How many participants are currently undergoing treatment in this clinical experiment?
"This clinical trial is no longer actively searching for candidates. It was first posted on October 28th, 2004 and the last update occurred November 19th 2022. For those who are seeking other trials to participate in, there are currently 3070 studies looking for individuals with hhv-8 and 1845 Natural History investigations open to applicants."
Has the FDA certified Natural History for its intended purpose?
"The safety of the Natural History trial was scored a 2 due to there being preliminary evidence in favour of its security, however no data validating its efficacy is available."
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