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Proton Beam Therapy
Proton Radiotherapy for Pediatric Brain Cancer
Phase 2
Waitlist Available
Led By Torunn I. Yock, MD
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Biopsy proven low grade glioma or astrocytoma, ependymoma, craniopharyngioma, meningioma, neurocytoma, medulloblastoma or gangliogliomas or other rare tumor requiring tumor bed or tumor irradiation
Age between 1-25 years
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 5 years
Awards & highlights
Study Summary
This trialis looking at a different radiation technique, proton radiotherapy, which aims to target brain tumors while sparing normal tissue from radiation-induced side effects.
Who is the study for?
This trial is for children and young adults aged 1-25 with certain brain tumors (like high-grade glioma, but not GBM, or non-disseminated ATRT) who haven't had radiotherapy in the same area before. They should have a life expectancy over a year and be willing to use contraception if applicable. It's not for those with metastases, uncontrolled illnesses that could affect participation, pregnant/breastfeeding women, or those unable to contribute to neurocognitive outcomes.Check my eligibility
What is being tested?
The study tests proton radiotherapy on pediatric brain tumors needing partial brain irradiation. Proton therapy targets tumors more precisely than standard radiation, potentially sparing healthy tissue and reducing side effects. The effectiveness of this technique compared to conventional methods is being evaluated.See study design
What are the potential side effects?
While proton radiotherapy aims to reduce side effects by sparing normal tissues from radiation exposure compared to standard therapy, potential side effects may still include skin reactions at the treatment site, fatigue, headaches, hair loss around the treated area and possible short-term cognitive changes.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I have a confirmed diagnosis of a specific brain tumor type.
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I am between 1 and 25 years old.
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I can care for myself but may not be able to do active work or play.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 5 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~5 years
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Endocrine dysfunction
Neurocognitive sequelae
Secondary outcome measures
Acute effects
Auditory function
Disease control
Trial Design
1Treatment groups
Experimental Treatment
Group I: Proton RadiotherapyExperimental Treatment1 Intervention
Proton Radiotherapy
Find a Location
Who is running the clinical trial?
National Cancer Institute (NCI)NIH
13,654 Previous Clinical Trials
40,933,053 Total Patients Enrolled
Massachusetts General HospitalLead Sponsor
2,928 Previous Clinical Trials
13,198,255 Total Patients Enrolled
Dana-Farber Cancer InstituteOTHER
1,078 Previous Clinical Trials
340,772 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I have cancer that has spread to my spine or other distant areas.I do not have any illnesses that would stop me from following the study's requirements.I have received radiotherapy on the area that needs treatment.I do not have severe neurological issues or language barriers preventing my participation.I have a confirmed diagnosis of a specific brain tumor type.I have a high-grade glioma (not GBM) or ATRT with complete surgery and no spread.I am between 1 and 25 years old.I can care for myself but may not be able to do active work or play.I agree to use birth control during the study.I am diagnosed with optic glioma or gliomas based on scans and symptoms.
Research Study Groups:
This trial has the following groups:- Group 1: Proton Radiotherapy
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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