Gene Therapy for Parkinson's Disease
Trial Summary
Do I need to stop taking my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications.
What data supports the effectiveness of the treatment AAV-GAD for Parkinson's Disease?
Gene therapy using adeno-associated virus (AAV) vectors has shown promise in treating Parkinson's Disease by delivering genes that help produce important brain chemicals like dopamine and GABA, which can improve motor functions. In one study, patients showed a 46% improvement in motor functions after receiving a similar AAV-based gene therapy, indicating potential effectiveness.12345
Is gene therapy using AAV-GAD safe for humans?
How is the treatment AAV-GAD unique for Parkinson's disease?
AAV-GAD is a gene therapy that uses a virus to deliver a gene into the brain, which helps produce GABA, a chemical that calms overactive brain areas in Parkinson's disease. This approach is different from traditional treatments that mainly focus on replacing dopamine, the brain chemical that is low in Parkinson's patients.138910
What is the purpose of this trial?
The objective of this study is to evaluate the long-term safety of AAV-GAD delivered bilaterally to the subthalamic nuclei (STN) in participants with Parkinson's disease.
Eligibility Criteria
This trial is for participants who were previously enrolled in Study MGT-GAD-025. There are no additional exclusion criteria, meaning that past participants of the mentioned study can join regardless of other conditions.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Active Treatment
Participants who received sham surgery will transition to an active treatment schedule including open-label bilateral treatment
Long-term Follow-up
Participants are monitored for long-term safety of AAV-GAD delivered bilaterally to the subthalamic nuclei
Treatment Details
Interventions
- AAV-GAD
Find a Clinic Near You
Who Is Running the Clinical Trial?
MeiraGTx, LLC
Lead Sponsor