Exercise Training for Cardiovascular Disease
(CIED-EX Trial)
Trial Summary
Will I have to stop taking my current medications?
The trial protocol does not specify whether you need to stop taking your current medications. It mentions that participants should be on optimal medical therapy, which suggests you may need to continue your current medications.
What data supports the effectiveness of the treatment High-intensity interval training (HIIT) and Moderate-intensity continuous training (MICT) for cardiovascular disease?
Research shows that high-intensity interval training (HIIT) can be more effective than moderate-intensity continuous training (MICT) in improving exercise capacity and reducing the risk of cardiovascular disease and mortality. HIIT has been found to increase peak oxygen uptake, which is a measure of how well your body uses oxygen during exercise, and improve overall heart health in patients with heart failure and coronary artery disease.12345
Is exercise training, like HIIT and MICT, safe for people with cardiovascular conditions?
Research shows that high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) are generally safe for people with cardiovascular conditions, with a low rate of major adverse events. In a review of 23 studies, only one major cardiovascular event occurred per 17,083 HIIT sessions, indicating a relatively low risk.36789
How does the treatment of high-intensity interval training (HIIT) differ from other treatments for cardiovascular disease?
High-intensity interval training (HIIT) is unique because it involves short bursts of intense exercise followed by rest, which can improve heart health more effectively than moderate-intensity continuous training (MICT). Studies suggest that HIIT may increase exercise capacity and reduce the risk of heart-related issues more than traditional continuous exercise.1231011
What is the purpose of this trial?
Cardiac implantable electronic devices (CIED) are established treatments for a variety of cardiac arrhythmias. Women with CIED have lower fitness and lower quality of life compared to men with CIED. Moderate-intensity continuous training (MICT) is the most prescribed exercise for women. However, high-intensity interval training (HIIT) has been shown to improve fitness, anxiety levels, quality of life, and other health indicators over MICT in men with CIED. There is a need to quantitatively evaluate the feasibility and effects of a virtual HIIT vs. virtual MICT program on the physical, quality of life, and mental health of women with CIED. Furthermore, a qualitative approach is also necessary to understand patients' experiences, barriers, and facilitators of a virtual exercise intervention. This mixed-methods pilot randomized controlled trial will assess the feasibility of a 12-week virtual HIIT and MICT program in women with CIED.
Research Team
Jennifer Reed, PhD
Principal Investigator
Ottawa Heart Institute Research Corporation
Eligibility Criteria
This trial is for women with cardiac devices (CIED) who've had them for at least 6 months, can read English or French, and are able to do a CPET exercise test. They should be on optimal medical therapy and not already doing regular exercise more than twice a week. Women who are pregnant or without internet cannot join.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo a 12-week virtual exercise program with either HIIT or MICT, conducted twice a week via Zoom.
Follow-up
Participants are monitored for safety and effectiveness after the exercise intervention, including assessments of cardiometabolic health indicators and mental health.
Treatment Details
Interventions
- High-intensity interval training (HIIT)
- Moderate-intensity continuous exercise training (MICT)
High-intensity interval training (HIIT) is already approved in European Union, United States for the following indications:
- Cardiovascular rehabilitation
- Improvement of peak oxygen uptake (VO2 peak)
- Enhancement of physical functioning and quality of life
- Cardiovascular rehabilitation
- Improvement of peak oxygen uptake (VO2 peak)
- Enhancement of physical functioning and quality of life
Find a Clinic Near You
Who Is Running the Clinical Trial?
Ottawa Heart Institute Research Corporation
Lead Sponsor