This trial is evaluating whether HIIT exercise will improve 1 primary outcome in patients with Endometrial Neoplasms. Measurement will happen over the course of 3 years.
This trial requires 20 total participants across 1 different treatment group
This trial involves a single treatment. HIIT Exercise is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.
"The current estimates suggest that in 2019, around 8,900 people will be diagnosed with an endometrial carcinoma. Compared to other benign and malignant lesions of the female reproductive system, endometrial neoplasms account for only 0.7% of all cancers in women." - Anonymous Online Contributor
"Common treatment options for endometrial cancer include surgery, radiation therapy, chemotherapy, or a combination of these. Rarely used option are cryoablation, embolization, neoadjuvant chemotherapy, or the combined modality of surgery with chemotherapy or radiation." - Anonymous Online Contributor
"Currently, the only effective strategy for endometrial cancer prevention is the monthly use by the woman of a low-dose form of conjugated equine estrogen, which is believed to reduce the risk of endometrial cancer by about 50% while minimizing the deleterious effects (side effects) of the hormone on the endometrium, such as endometrial hyperplasia and endometrial polyps." - Anonymous Online Contributor
"There is an increasing incidence of endometrial neoplasms, including endometrial polyps and [endometrial cancer](https://www.withpower.com/clinical-trials/endometrial-cancer), over recent years. Patients with these conditions are younger and are more likely to develop second primary cancers. The epidemiology, management, and treatment of endometrial neoplasms differ from that of other ovarian neoplasms." - Anonymous Online Contributor
"Symptoms vary among patients with endometrial cancer, but most common symptoms are erythro- or azotemia, unexplained weight loss, pelvic pain, pelvic mass, and vaginal bleeding. The presence of infertility also seems to be closely related. Physicians should consider endometrial cancer in the differential diagnosis when patients present with unexplained infertility and persistent menorrhagia." - Anonymous Online Contributor
"In an age group in which there is a high prevalence of endometrial cancers due to adenocarcinoma and carcinoid tumours, it is unlikely the majority of cases are due to mutations in genes that cause non-hereditary diseases. Instead, they may be due to environmental exposures at or around the turn of the 20th century that, in our view, were too far away in time to be related to the underlying pathology and to be capable as a cause of endometrial neoplasms. The only plausible possible cause is pollution from coal or asbestos based coal-gas lighting, now rare." - Anonymous Online Contributor
"The main cause of endometrial neoplasms is not identified in only 15%-50% of patients. However, the cause tends to be identifiable in a considerable portion of these patients with advanced endometrial neoplasms." - Anonymous Online Contributor
"HIIT has significant effects on mood and body composition in young and middle-aged women. As a result of these side effects, HIIT should not be considered as a safe alternative for physical training, particularly for younger women. Further studies with larger sample sizes are needed to confirm our findings." - Anonymous Online Contributor
"It can be concluded that the treatment is clinically effective in reducing the symptoms of endometrial neoplasms. Furthermore, it can have a long-lasting effect on endometrial neoplasms which can decrease the rate of cancerous growth." - Anonymous Online Contributor
"Hiit seems to be more effective than a placebo, but the difference is only clear in the endometrial cancer subgroup of which a significant difference in end of-study treatment response could not be assessed. However, a meta-analysis reveals a trend towards a reduction of the time to progression in the group reporting exercise adherence. Based on currently available randomized trial evidence, and the results from previous studies we can conclude only modest support for exercise, and even this for people with endometrial cancer." - Anonymous Online Contributor
"The incidence of endometrial neoplasms appears to be higher in women from family members who have neoplasms compared to women from family members without an endometrial neoplasm; the risk appears greatest in a subgroup of women with early onset disease. Women with familial endometrial neoplasms should be counseled of the increased risk of neoplasms and provided with detailed genetic testing of known and potential cancer genes." - Anonymous Online Contributor
"The existing studies do not provide sufficient data for the establishment of a clear recommendation for the use of endometrial cytology in women of reproductive ages. The potential risks, and if there are any, do not seem to be adequately described in literature." - Anonymous Online Contributor