HIIT exercise for Endometrial Neoplasms

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC
Endometrial Neoplasms+1 More
HIIT exercise - Behavioral
Eligibility
18+
Female
Eligible conditions
Select

Study Summary

This study is evaluating whether high intensity interval training (HIIT) has anti-cancer effects.

See full description

Eligible Conditions

  • Endometrial Neoplasms
  • Endometrial Cancer

Treatment Effectiveness

Effectiveness Estimate

1 of 3

Compared to trials

Study Objectives

This trial is evaluating whether HIIT exercise will improve 1 primary outcome in patients with Endometrial Neoplasms. Measurement will happen over the course of 3 years.

3 years
Change in proliferative markers in endometrium before and after HIIT exercises

Trial Safety

Safety Estimate

1 of 3

Compared to trials

Trial Design

1 Treatment Group

HIIT exercise
1 of 1
Experimental Treatment

This trial requires 20 total participants across 1 different treatment group

This trial involves a single treatment. HIIT Exercise is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

HIIT exercise
Behavioral
Participants will perform HIIT exercises as instructed by the study team in the weeks prior to standard of care surgery

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 3 years
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 3 years for reporting.

Closest Location

UNC Lineberger Comprehensive Cancer Center - Chapel Hill, NC

Eligibility Criteria

This trial is for female patients aged 18 and older. There are 9 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Patients with a diagnosis of endometrial cancer who are to undergo hysterectomy and staging
Between 40-75 years old
Body mass index of 30-50 kg/m2
Endometrioid histology endometrial cancer
Presumed clinically early stage disease (disease confined to uterus only)
Have access to a Smart Phone
Have access to email
Agree to visit the exercise and sport science laboratory within 2 days of SOC visit for baseline testing if enrollment procedures cannot be done on the same day.
Agree to visit clinic 2 (+/-2wks) weeks after surgery for SOC follow-up and post surgery visit, or willing to return to exercise and sport science laboratory 2 (+/-2wks) weeks post-surgery

Patient Q&A Section

How many people get endometrial neoplasms a year in the United States?

"The current estimates suggest that in 2019, around 8,900 people will be diagnosed with an endometrial carcinoma. Compared to other benign and malignant lesions of the female reproductive system, endometrial neoplasms account for only 0.7% of all cancers in women." - Anonymous Online Contributor

Unverified Answer

What are common treatments for endometrial neoplasms?

"Common treatment options for endometrial cancer include surgery, radiation therapy, chemotherapy, or a combination of these. Rarely used option are cryoablation, embolization, neoadjuvant chemotherapy, or the combined modality of surgery with chemotherapy or radiation." - Anonymous Online Contributor

Unverified Answer

Can endometrial neoplasms be cured?

"Currently, the only effective strategy for endometrial cancer prevention is the monthly use by the woman of a low-dose form of conjugated equine estrogen, which is believed to reduce the risk of endometrial cancer by about 50% while minimizing the deleterious effects (side effects) of the hormone on the endometrium, such as endometrial hyperplasia and endometrial polyps." - Anonymous Online Contributor

Unverified Answer

What is endometrial neoplasms?

"There is an increasing incidence of endometrial neoplasms, including endometrial polyps and [endometrial cancer](https://www.withpower.com/clinical-trials/endometrial-cancer), over recent years. Patients with these conditions are younger and are more likely to develop second primary cancers. The epidemiology, management, and treatment of endometrial neoplasms differ from that of other ovarian neoplasms." - Anonymous Online Contributor

Unverified Answer

What are the signs of endometrial neoplasms?

"Symptoms vary among patients with endometrial cancer, but most common symptoms are erythro- or azotemia, unexplained weight loss, pelvic pain, pelvic mass, and vaginal bleeding. The presence of infertility also seems to be closely related. Physicians should consider endometrial cancer in the differential diagnosis when patients present with unexplained infertility and persistent menorrhagia." - Anonymous Online Contributor

Unverified Answer

What causes endometrial neoplasms?

"In an age group in which there is a high prevalence of endometrial cancers due to adenocarcinoma and carcinoid tumours, it is unlikely the majority of cases are due to mutations in genes that cause non-hereditary diseases. Instead, they may be due to environmental exposures at or around the turn of the 20th century that, in our view, were too far away in time to be related to the underlying pathology and to be capable as a cause of endometrial neoplasms. The only plausible possible cause is pollution from coal or asbestos based coal-gas lighting, now rare." - Anonymous Online Contributor

Unverified Answer

What is the primary cause of endometrial neoplasms?

"The main cause of endometrial neoplasms is not identified in only 15%-50% of patients. However, the cause tends to be identifiable in a considerable portion of these patients with advanced endometrial neoplasms." - Anonymous Online Contributor

Unverified Answer

What are the common side effects of hiit exercise?

"HIIT has significant effects on mood and body composition in young and middle-aged women. As a result of these side effects, HIIT should not be considered as a safe alternative for physical training, particularly for younger women. Further studies with larger sample sizes are needed to confirm our findings." - Anonymous Online Contributor

Unverified Answer

What are the latest developments in hiit exercise for therapeutic use?

"It can be concluded that the treatment is clinically effective in reducing the symptoms of endometrial neoplasms. Furthermore, it can have a long-lasting effect on endometrial neoplasms which can decrease the rate of cancerous growth." - Anonymous Online Contributor

Unverified Answer

Has hiit exercise proven to be more effective than a placebo?

"Hiit seems to be more effective than a placebo, but the difference is only clear in the endometrial cancer subgroup of which a significant difference in end of-study treatment response could not be assessed. However, a meta-analysis reveals a trend towards a reduction of the time to progression in the group reporting exercise adherence. Based on currently available randomized trial evidence, and the results from previous studies we can conclude only modest support for exercise, and even this for people with endometrial cancer." - Anonymous Online Contributor

Unverified Answer

Does endometrial neoplasms run in families?

"The incidence of endometrial neoplasms appears to be higher in women from family members who have neoplasms compared to women from family members without an endometrial neoplasm; the risk appears greatest in a subgroup of women with early onset disease. Women with familial endometrial neoplasms should be counseled of the increased risk of neoplasms and provided with detailed genetic testing of known and potential cancer genes." - Anonymous Online Contributor

Unverified Answer

What is the latest research for endometrial neoplasms?

"The existing studies do not provide sufficient data for the establishment of a clear recommendation for the use of endometrial cytology in women of reproductive ages. The potential risks, and if there are any, do not seem to be adequately described in literature." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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