High-Intensity Exercise for Alzheimer's Disease
(CYCLE-AD Trial)
Trial Summary
Will I have to stop taking my current medications?
The trial requires that participants do not currently use Alzheimer's disease medications, including cholinesterase inhibitors and memantine. Other medications are not specifically mentioned, so it's best to discuss your current medications with the study doctor.
What data supports the effectiveness of the treatment Indoor Cycling (IC), High-Intensity Interval Training (HIIT), Stationary Cycling, Home-Based Cycling, Peloton Cycling for Alzheimer's Disease?
Research suggests that exercise, including cycling, may help improve daily life activities, mental health, and physical fitness in people with Alzheimer's disease. While specific data on cycling is limited, general exercise has shown benefits in flexibility, balance, and some cognitive functions.12345
Is high-intensity exercise safe for people with Alzheimer's disease?
How does the treatment of high-intensity exercise differ from other treatments for Alzheimer's disease?
What is the purpose of this trial?
The overall goal of the CYCLE-AD trial is to determine the role of long-term, high intensity exercise in slowing or delaying the onset of cognitive and AD-related brain changes in e4 carriers. Successful translation and demonstration of the effectiveness of a scalable home-based exercise intervention capable of slowing or delaying disease onset will transform AD treatment, improve patient outcomes and quality of life, and reduce health care costs.
Research Team
Jay L Alberts, PhD
Principal Investigator
The Cleveland Clinic
Stephen Rao, PhD
Principal Investigator
The Cleveland Clinic
Eligibility Criteria
The CYCLE-AD trial is for healthy elders aged 65-80 with no cognitive impairment, carrying the APOE ε4 gene. Participants should be inactive (exercising less than three times a week), fluent in English, able to use a Peloton bike safely, and have in-home Wi-Fi. They must not have severe medical conditions or plan extensive travel during the study.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants engage in high-intensity interval training (HIIT) using the Peloton® cycling system or continue their habitual physical activity for 18 months
Follow-up
Participants are monitored for safety and effectiveness after treatment, including cognitive testing and brain MR imaging
Treatment Details
Interventions
- Indoor Cycling (IC)
Find a Clinic Near You
Who Is Running the Clinical Trial?
The Cleveland Clinic
Lead Sponsor
National Institutes of Health (NIH)
Collaborator
University of Maryland, College Park
Collaborator
National Institute on Aging (NIA)
Collaborator