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Behavioural Intervention

High-Intensity + Home Exercise for Cognitive Impairment (HEALTH-COG Trial)

N/A

Recruiting

Research Sponsored by University of Alabama at Birmingham

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

On a current, contemporary ART regimen for >=12 months

Fatigued (≥2.0 on either of the first two screening items on the HIV-Related Fatigue Scale)

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 12 month follow-up visit

Awards & highlights

HEALTH-COG Trial Summary

This trial aims to discover if physical activity can reduce Alzheimer's risk for aging people with HIV - few studies have tested this yet.

Who is the study for?

This trial is for older individuals living with HIV who have low viral loads, are on stable antiretroviral therapy, experience fatigue, and lead a sedentary lifestyle. They must be willing to exercise regularly and able to receive text messages. Exclusions include severe health conditions like heart failure, uncontrolled hypertension or diabetes, recent major surgery or injury, and certain medication uses.Check my eligibility

What is being tested?

The study tests the effects of high-intensity gym exercises followed by home exercise coaching via text messages on cognitive function in older people with HIV. It aims to see if these interventions can improve brain health and establish long-term exercise habits.See study design

What are the potential side effects?

While not explicitly listed in the provided information, potential side effects from intense physical activity may include muscle soreness, joint pain, increased fatigue initially before improvement in endurance occurs.

HEALTH-COG Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I have been on my current HIV treatment for at least 12 months.

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I often feel very tired.

HEALTH-COG Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 12 month follow-up visit

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~12 month follow-up visit

This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 month follow-up visit for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Cognition

Secondary outcome measures

Psychological Mechanisms of Adherence

HEALTH-COG Trial Design

2Treatment groups

Active Control

Group I: High-Intensity Interval Training (HIIT)Active Control3 Interventions

Following a 5-minute warm-up at 50% VO2peak, high and moderate-intensity exercise bouts alternate, progressing to five bouts of 4-minute high-intensity exercise (90% VO2peak), alternating with four 3-minute bouts of moderate-intensity exercise (50% VO2peak) by week 8, followed by a 5 minute cool-down. The total exercise time is 42 minutes.

Group II: Continuous Moderate Exercise (CME)Active Control3 Interventions

Following a 4 minute warm-up at 50% VO2peak, the participant walks for up to 42 continuous minutes at 60% VO2peak172, followed by a 4 minute cool-down. The total exercise time is 50 minutes.

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of Alabama at BirminghamLead Sponsor

1,590 Previous Clinical Trials

2,281,352 Total Patients Enrolled

University of Colorado, DenverOTHER

1,738 Previous Clinical Trials

2,149,416 Total Patients Enrolled

National Institute on Aging (NIA)NIH

1,675 Previous Clinical Trials

28,020,775 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this research endeavor open to adults of legal age?

"In adherence with the prerequisites of this trial, participants must be between 50 and 80 years old."

Answered by AI

Is my profile suitable for this clinical experiment?

"To be eligible for inclusion in this clinical trial, applicants must have HIV and be between the age of 50 to 80. The goal is to recruit a total of 110 patients."

Answered by AI

Is enrollment still available for this experiment?

"According to information found on clinicaltrials.gov, this trial is no longer accepting participants at the present time. Initially posted in September of 2023 and last updated in August of the same year, it appears that recruitment for this study has now ended; however, there are 1136 other medical trials currently recruiting patients right now."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Effect of High-Intensity Exercise to Attenuate Cognitive Function Limitations and Train Exercise Habits in Older People Living With HIV

Pariya L. Fazeli, PhD 2023. "Effect of High-Intensity Exercise to Attenuate Cognitive Function Limitations and Train Exercise Habits in Older People Living With HIV". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06013579.