Aerobic Exercise for Depression

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
University of Ottawa Institute of Mental Health Research, Ottawa, CanadaDepressionAerobic Exercise - Behavioral
Eligibility
16 - 24
All Sexes
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Study Summary

This trial will compare the effects of moderate vs. high intensity aerobic exercise on depression, cognition, and brain function in young adults.

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

5 Primary · 6 Secondary · Reporting Duration: Baseline, Mid-Intervention (6 weeks), Post-Intervention (12 weeks), 3-month follow-up, 6-month follow-up

Assessed per participant, through study completion
Adherence to moderate & high intensity exercise regimens as prescribed
Compliance to moderate & high intensity exercise regimens as prescribed
Week 12
Changes in electrocortical-indexed brain activity profiles
Changes to neuroimaging-indexed brain activity profiles
Week 12
Changes in clinician-rated depression-related symptoms
Changes in cognitive function
Changes in daily functioning
Changes in self-mastery
Changes to self-esteem
Week 12
Changes in self-reported depression-related symptoms
Month 24
Feasibility of moderate & high intensity aerobic exercise as a treatment regimen.

Trial Safety

Side Effects for

Standard Care Plus Exercise Program
1%Malignant melanoma
This histogram enumerates side effects from a completed 2013 Phase 3 trial (NCT01065506) in the Standard Care Plus Exercise Program ARM group. Side effects include: Malignant melanoma with 1%.

Trial Design

2 Treatment Groups

Moderate Intensity
1 of 2
High Intensity
1 of 2

Experimental Treatment

40 Total Participants · 2 Treatment Groups

Primary Treatment: Aerobic Exercise · No Placebo Group · N/A

Moderate Intensity
Behavioral
Experimental Group · 1 Intervention: Aerobic Exercise · Intervention Types: Behavioral
High Intensity
Behavioral
Experimental Group · 1 Intervention: Aerobic Exercise · Intervention Types: Behavioral
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Aerobic Exercise
2013
Completed Phase 3
~1510

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: baseline, mid-intervention (6 weeks), post-intervention (12 weeks), 3-month follow-up, 6-month follow-up

Who is running the clinical trial?

The Royal's Institute of Mental Health ResearchLead Sponsor
2 Previous Clinical Trials
1,018 Total Patients Enrolled

Eligibility Criteria

Age 16 - 24 · All Participants · 6 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You are not currently exercising regularly at a moderate or high intensity level.
You are currently going through a period of depression.

Frequently Asked Questions

What ultimate goals are investigators hoping to accomplish with this trial?

"This clinical trial will span several checkpoints, including Baseline, Mid-Intervention (6 weeks), Post-Intervention (12 weeks), 3-month follow-up and 6 month follow up. The investigation's primary objective is to measure shifts in depression related symptoms as reviewed by clinicians. Secondary outcomes are changes to cognitive function evaluated with the NIH Cognitive Toolbox; a compilation of seven computerised tests designed to assess multiple intellectual capacities. This data will then be combined for analysis. Additionally, self mastery appraisals using Perlin/Schooler’s Mastery Scale - a 7 item questionnaire - along with neuroimaging indexed brain activity" - Anonymous Online Contributor

Unverified Answer

Are there any limits on the number of participants enrolling in this experiment?

"Correct. According to the information stored on clinicaltrials.gov, this trial is actively seeking out 40 participants from a single medical centre. The study was initially posted on August 7th 2018 and has since been updated as recently as May 2nd 2022." - Anonymous Online Contributor

Unverified Answer

To what demographic is this experiment open?

"This study is seeking around 40 individuals with depression aged between 16 and 24. Those who meet these requirements may be accepted in the trial." - Anonymous Online Contributor

Unverified Answer

Is there an age requirement to be eligible for this medical trial?

"Based on the inclusion criteria, this study is open to individuals aged 16 to 24. There are 177 clinical trials that focus specifically on minors and 848 dedicated to those over 65 years old." - Anonymous Online Contributor

Unverified Answer

Are there any open opportunities to participate in this research?

"Clinicaltrials.gov states that this experiment is currently searching for study participants, with the original posting taking place on August 7th 2018 and most recent edits occurring May 2nd 2022." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.