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Heat Therapy and High-Intensity Training for Exercise Intolerance

N/A

Recruiting

Led By Robert Hyldahl, Ph.D.

Research Sponsored by Brigham Young University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Currently no cardiovascular or metabolic disease (e.g. heart failure, diabetes)

18-95 years of age

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 3-8 weeks

Awards & highlights

Study Summary

This trial will measure knee extensor CP in young and old individuals to determine how changes in muscle oxygen delivery, muscle mass, and composition, and mitochondrial oxygen consumption contribute to the decrease in CP with age. The trial will also examine the effectiveness of two different therapies—high intensity interval training and muscle heat therapy—at improving muscle function and critical power in young and older adults. Finally, the trial will examine the impact of muscle disuse on muscle function and critical power and determine if heat therapy is an effective means of minimizing the impact of disuse on muscle function and critical power.

Who is the study for?

This trial is for individuals aged 18-95 who can perform knee extension exercises and have no current cardiovascular or metabolic diseases like heart failure or diabetes. It's not suitable for those who are pregnant, have been exercising regularly in the last six months, or cannot do knee extensions.Check my eligibility

What is being tested?

The study tests how well High Intensity Interval Training (HIIT) and Muscle Heat Therapy improve muscle function and exercise tolerance in young and older adults. It also looks at the effects of leg immobilization on these factors and if heat therapy can minimize its impact.See study design

What are the potential side effects?

Potential side effects may include discomfort from heat application during Muscle Heat Therapy, fatigue from High Intensity Interval Training, soreness after exercise sessions, and possible temporary loss of muscle function due to disuse.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I do not have heart disease or diabetes.

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I am between 18 and 95 years old.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 3-8 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~3-8 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and 3-8 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Muscle Critical Power

Secondary outcome measures

Maximum Exercise Blood Flow

Muscle Fiber Size

Muscle Mitochondrial Function

+2 more

Trial Design

5Treatment groups

Experimental Treatment

Placebo Group

Group I: Effect of Muscle Heat TherapyExperimental Treatment1 Intervention

Young and older subjects will participate in single-leg,heat therapy training of a single leg ( quadriceps femoris, 120 minutes of shortwave diathermy to raise the muscle temperature to ~39C) 3 times a week for 6 weeks. Muscle function and knee extensor critical power will be measured before and after the 6 weeks of treatment.

Group II: Effect of Immobilization with Daily Heat TherapyExperimental Treatment1 Intervention

Young subjects (18-35 years) will undergo 2 weeks of leg immobilization while receiving 2 hours of heat therapy treatment each day. Heat therapy will consist of 120 minutes of shortwave diathermy to raise the quadriceps femoris muscle temperature to ~39C. Muscle function and knee extensor critical power will be measured before and after the 2 weeks of leg immobilization.

Group III: Effect of High Intensity Interval TrainingExperimental Treatment1 Intervention

Young and older subjects will participate in single-leg, high-intensity interval training of the right knee extensors (4 intervals of 4 minutes at 80% of max aerobic power with 4 minute rest intervals between, 3x per week for 6 weeks). Muscle function and knee extensor critical power will be measured before and after the 6 weeks of treatment.

Group IV: Effect of Sham Muscle Heat TherapyPlacebo Group1 Intervention

Young and older subjects will participate in a sham treatment of single-leg,heat therapy training of the right knee extensors (120 minutes with shortwave diathermy unit positioned on leg, but not turned on) 3 times a week for 6 weeks. Muscle function and knee extensor critical power will be measured before and after the 6 weeks of treatment.

Group V: Effect of Immobilization with Daily Sham Heat TherapyPlacebo Group1 Intervention

Young subjects (18-35 years) will undergo 2 weeks of leg immobilization while receiving 2 hours of a sham heat therapy treatment each day. For the sham treatment, the heating device will be applied to the limb, but, unbeknownst to the participant, it will not be turned on. Muscle function and knee extensor critical power will be measured before and after the 2 weeks of leg immobilization.

0 / 2Eligibility criteria met

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Who is running the clinical trial?

Brigham Young UniversityLead Sponsor

22 Previous Clinical Trials

10,074 Total Patients Enrolled

Robert Hyldahl, Ph.D.Principal InvestigatorBrigham Young Univeristy

Jayson Gifford, Ph.D.Study Director - Brigham Young University

Brigham Young University

Media Library

High Intensity Interval Training of the Knee Extensors Clinical Trial Eligibility Overview. Trial Name: NCT04733287 — N/A

High Intensity Interval Training Research Study Groups: Effect of High Intensity Interval Training, Effect of Muscle Heat Therapy, Effect of Immobilization with Daily Heat Therapy, Effect of Sham Muscle Heat Therapy, Effect of Immobilization with Daily Sham Heat Therapy

High Intensity Interval Training Clinical Trial 2023: High Intensity Interval Training of the Knee Extensors Highlights & Side Effects. Trial Name: NCT04733287 — N/A

High Intensity Interval Training of the Knee Extensors 2023 Treatment Timeline for Medical Study. Trial Name: NCT04733287 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this research currently accepting participants?

"Yes, the available information published on clinicaltrials.gov indicates that this medical research is still recruiting participants. It was advertised on April 1st 2021 and last updated January 27th 2021 with a goal to enrol 148 patients in one location."

Answered by AI

How many human subjects are participating in this investigation?

"Affirmative. Clinicaltrials.gov evidences that this clinical trial, which was published on April 1st 2021, is actively searching for participants. 148 people must be enlisted from a single medical centre."

Answered by AI

Are individuals below the age of 25 permissible to volunteer for this investigation?

"The parameters for inclusion in this medical trial are between 18 and 95 years of age. There is a seperate set of trials catered to adolescents under the age of 18 while 240 studies have been created specifically for individuals over 65."

Answered by AI

Am I eligible to take part in this clinical experiment?

"Qualified applicants to this medical research must be between 18 and 95 years old, suffer from exercise intolerance, and out of the 148 total participants needed for the study."

Answered by AI

Recent research and studies

Journal of Applied PhysiologyJournal

Repeated Exposure to Heat Stress Induces Mitochondrial Adaptation in Human Skeletal Muscle

Hafen, Paul S., Coray N. Preece, Jacob R. Sorensen, Chad R. Hancock, and Robert D. Hyldahl. 2018. “Repeated Exposure to Heat Stress Induces Mitochondrial Adaptation in Human Skeletal Muscle”. Journal of Applied Physiology. American Physiological Society. doi:10.1152/japplphysiol.00383.2018.

Journal of Applied PhysiologyJournal

CORP: Ultrasound Assessment of Vascular Function with the Passive Leg Movement Technique

Gifford, Jayson R., and Russell S. Richardson. 2017. “CORP: Ultrasound Assessment of Vascular Function with the Passive Leg Movement Technique”. Journal of Applied Physiology. American Physiological Society. doi:10.1152/japplphysiol.00557.2017.

American Journal of Physiology-Heart and Circulatory PhysiologyJournal

Impact of Age on the Vasodilatory Function of Human Skeletal Muscle Feed Arteries

Park, Song-Young, Stephen J. Ives, Jayson R. Gifford, Robert H. I. Andtbacka, John R. Hyngstrom, Van Reese, Gwenael Layec, Leena P. Bharath, John D. Symons, and Russell S. Richardson. 2016. “Impact of Age on the Vasodilatory Function of Human Skeletal Muscle Feed Arteries”. American Journal of Physiology-heart and Circulatory Physiology. American Physiological Society. doi:10.1152/ajpheart.00716.2015.

Journal of Applied PhysiologyJournal