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Drug Combinations for Kidney Cancer
Study Summary
This trial is testing whether two different combinations of drugs are better than another combination of drugs at treating kidney cancer.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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- I started treatment for bone loss at least 2 weeks before joining the study.I have had or currently have lung inflammation treated with steroids.I have a history of Hepatitis B.I have not had major surgery within the last 4 weeks, except for kidney removal.I have a preexisting abnormal connection between two body parts.My cancer is affecting a major blood vessel.My cancer has spread to my brain or spinal cord.I am currently being treated for an infection.I have had a serious heart condition in the last year.I have a history of lung scarring or fibrosis.My blood pressure is under control, with or without medication.My organs are functioning well.I am a male who will not have sex or will use birth control during and for 7 days after my last dose of the study drugs.I had fluid in my chest but am stable after treatment.I have an immune system disorder or have been on steroids or other immune-weakening medicines recently.I am not pregnant or breastfeeding, and if I can have children, I use effective birth control or practice abstinence.I have another cancer that is getting worse or was treated in the last 3 years.I had radiotherapy less than 2 weeks before starting the study treatment.I have received an organ or tissue transplant from another person.I have not received a live vaccine within the last 30 days.I have an autoimmune disease treated with medication in the last 2 years.You have been diagnosed with HIV.I have had significant bleeding issues in the last 3 months.I need extra oxygen sometimes or all the time.My kidney cancer has been confirmed to have a clear cell component.I have not had any treatment for advanced kidney cancer.
- Group 1: Pembrolizumab/Quavonlimab + Lenvatinib
- Group 2: Pembrolizumab + Lenvatinib
- Group 3: Pembrolizumab + Belzutifan + Lenvatinib
- Pivotal Trial - The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Has the FDA cleared Pembrolizumab/Quavonlimab for use?
"Data supporting the efficacy of Pembrolizumab/Quavonlimab exists, as this is a Phase 3 trial. Furthermore, multiple rounds of data supporting the safety of this medication also exist, leading our team at Power to rate its safety a 3."
What medical conditions does Pembrolizumab/Quavonlimab help alleviate?
"Pembrolizumab/Quavonlimab can help patients with unresectable melanoma as well as those with a high risk of microsatellite instability high, recurrence, and disease."
What other research has been conducted that focuses on Pembrolizumab/Quavonlimab?
"At present, there are 1087 active Pembrolizumab/Quavonlimab studies. Out of these, 135 are in Phase 3. The location of these studies is largely based in Sacramento, California; however, there are 37587 different centres conducting these trials."
Is this experiment looking for new test subjects?
"The latest information available on clinicaltrials.gov affirms that this trial is still open and recruiting patients. The trial was initially posted on April 14th, 2021 and the 1653 patients needed are being recruited from 39 different locations."
Please list the different places where this research is being conducted.
"This experiment is being conducted out of CHUQ-Univ Laval-Hotel Dieu de Quebec ( Site 0112) in Quebec, Minnesota, Cancer Research Center - HealthPartners/Park Nicollet ( Site 0005) in Saint Louis Park, Massachusetts, and Massachusetts General Hospital ( Site 0094) in Boston, Oregon among other locations."
Who else is applying?
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What portion of applicants met pre-screening criteria?
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