Cryoanalgesia for Postoperative Pain

Northwestern University, Chicago, IL
Postoperative PaincryoICE® system (AtriCure, Inc) with CryoSphere (CryoS) probe - Device
All Sexes
What conditions do you have?

Study Summary

This trial will study the use of cold temperatures to reduce pain and opioid use in cardiac surgery patients. Results may provide an alternative to traditional pain control methods.

Treatment Effectiveness

Study Objectives

1 Primary · 5 Secondary · Reporting Duration: 24 hours/POD1 (post-operative day 1), 48 hours/POD2, 10 days +/- 4 days, 90 days +/- 14 days, & 180 days +/- 30 days

Day 180
Pain Quality
Pain Severity
Patient Satisfaction with Pain Control Regimen
48 hours
Average Daily Opioid Consumption in MME
Day 180
Quality of Recovery Score
Hour 48
Average Daily Pain Scores

Trial Safety

Awards & Highlights

No Placebo Group
All patients enrolled in this trial will receive the new treatment.

Trial Design

2 Treatment Groups

Standard of Care (Control)
1 of 2
1 of 2

Active Control

Experimental Treatment

32 Total Participants · 2 Treatment Groups

Primary Treatment: Cryoanalgesia · No Placebo Group · N/A

Experimental Group · 1 Intervention: cryoICE® system (AtriCure, Inc) with CryoSphere (CryoS) probe · Intervention Types: Device
Standard of Care (Control)NoIntervention Group · 1 Intervention: Standard of Care (Control) · Intervention Types:

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 24 hours/pod1 (post-operative day 1), 48 hours/pod2, 10 days +/- 4 days, 90 days +/- 14 days, & 180 days +/- 30 days

Who is running the clinical trial?

Northwestern UniversityLead Sponsor
1,501 Previous Clinical Trials
866,531 Total Patients Enrolled
5 Trials studying Postoperative Pain
297 Patients Enrolled for Postoperative Pain

Eligibility Criteria

Age 18+ · All Participants · 2 Total Inclusion Criteria

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Frequently Asked Questions

What is the current participant pool for this clinical trial?

"Affirmative. According to the archive, this medical study is currently recruiting participants, having been initially posted on April 10th 2023 and last updated on May 11th 2023. The trial requires 32 patients to be enrolled from 1 site location." - Anonymous Online Contributor

Unverified Answer

Are recruitment opportunities still available for this investigation?

"According to, the search for patients is underway as of this writing. This medical trial was initially listed on April 10th 2023 and underwent its last edit on May 11th 2023." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.