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Neuromodulation

Active rTMS for Schizophrenia

N/A
Waitlist Available
Led By Xiaoming Du, PhD
Research Sponsored by The University of Texas Health Science Center, Houston
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 weeks
Awards & highlights

Study Summary

This trial will test if using a type of magnetic stimulation can help improve the brain's white matter in patients with schizophrenia spectrum disorder.

Who is the study for?
This trial is for men and women aged 18-60 with schizophrenia-spectrum disorder who can consent to participate. It's not for lab employees, those unable to avoid alcohol/marijuana before experiments, people with significant head injuries or brain conditions, severe drug users, individuals with a history of seizures or thrombosis risks, those on high doses of clozapine (>400 mg/day), or pregnant women.Check my eligibility
What is being tested?
The study tests if active repetitive transcranial magnetic stimulation (rTMS) using an H-coil can improve white matter integrity in patients with schizophrenia spectrum disorder. The goal is to enhance brain connectivity through neuromodulation.See study design
What are the potential side effects?
Potential side effects may include discomfort at the stimulation site, headache, lightheadedness, twitching of facial muscles during treatment sessions and in rare cases could potentially trigger seizures.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Resting-state functional connectivity (rsFC) from functional MRI
brain microstructural integrity from magnetic resonance imaging (MRI)
Secondary outcome measures
Cognitive functions measured by the MATRICS consensus cognitive battery (MCCB)
Cognitive insight, depression, perception, and delusion measured from questionnaires
Electrophysiological responses measured by mismatch negativity and steady-state auditory evoked potentials from electroencephalography recording (EEG)

Trial Design

1Treatment groups
Experimental Treatment
Group I: Active rTMSExperimental Treatment1 Intervention
Participants in this group will receive active H-coil delivered rTMS.

Find a Location

Who is running the clinical trial?

The University of Texas Health Science Center, HoustonLead Sponsor
903 Previous Clinical Trials
320,857 Total Patients Enrolled
4 Trials studying Schizophrenia
185 Patients Enrolled for Schizophrenia
Xiaoming Du, PhDPrincipal InvestigatorThe University of Texas Health Science Center, Houston
2 Previous Clinical Trials
110 Total Patients Enrolled
2 Trials studying Schizophrenia
110 Patients Enrolled for Schizophrenia

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are individuals who are older than 35 years eligible to participate in this medical study?

"This investigation is currently seeking individuals who are older than 18 years but younger than 60."

Answered by AI

Is it possible for me to be enrolled as a participant in this medical study?

"Individuals aged between 18 and 60 years diagnosed with schizophrenia are eligible to participate in this study. A total of 120 participants will be enrolled in the clinical trial."

Answered by AI

Are there any available vacancies for potential participants in this research study?

"As seen on clinicaltrials.gov, the current status of this research project shows that it is not in a phase of enrolling participants. The trial was initially listed for recruitment on May 1st, 2024, and its latest update was made on March 28th, 2024. Despite the temporary pause in enrollment, there are currently ongoing recruitment activities for 340 other clinical investigations."

Answered by AI

Who else is applying?

What site did they apply to?
The University of Texas Health Science Center, Houston
What portion of applicants met pre-screening criteria?
Met criteria
Recent research and studies
clinicaltrials.govStudy
Enhancing Brain Connectivity in Schizophrenia Through Neuromodulation (Study 1)
Xiaoming Du 2024. "Enhancing Brain Connectivity in Schizophrenia Through Neuromodulation (Study 1)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06345963.
~80 spots leftby May 2029
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